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PreprintCC BY-NDbioRxiv

Genetic background influences cocaine neuroplasticity in the accumbens shell of male mice

  • C. A. Nwakama
  • A. D. Chapp1
  1. 1University of Minnesota
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Abstract

Genetics shape cocaine behavior and abuse liability, but the underlying neurophysiological effects remain understudied. In male C57BL/6J, B6129SF2/J, and DO/J mice, we report conserved and divergent cocaine induced neuroplasticity in the accumbens shell following 5 days of cocaine and 10 to 14 days of abstinence.

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Cite

BibTeXRIS
BibTeX
@misc{nwakama2026genetic,
  title = {{Genetic background influences cocaine neuroplasticity in the accumbens shell of male mice}},
  author = {C. A. Nwakama and A. D. Chapp},
  howpublished = {bioRxiv},
  year = {2026},
  month = sep,
  doi = {10.64898/2026.09.21.753182},
  url = {https://www.biorxiv.org/content/10.64898/2026.09.21.753182v1},
  note = {CC BY-ND},
}
RIS
TY  - UNPB
TI  - Genetic background influences cocaine neuroplasticity in the accumbens shell of male mice
AU  - C. A. Nwakama
AU  - A. D. Chapp
PY  - 2026
DA  - 2026/09/21
PB  - bioRxiv
DO  - 10.64898/2026.09.21.753182
UR  - https://www.biorxiv.org/content/10.64898/2026.09.21.753182v1
AB  - Genetics shape cocaine behavior and abuse liability, but the underlying neurophysiological effects remain understudied. In male C57BL/6J, B6129SF2/J, and DO/J mice, we report conserved and divergent cocaine induced neuroplasticity in the accumbens shell following 5 days of cocaine and 10 to 14 days of abstinence.
ER  -