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Peer-reviewedCC BY 4.0American Heart Journal Plus: Cardiology Research and Practice

Association between platelet indices and VCAM-1 levels in patients with coronary artery disease

  • Ariosta1,2
  • Banundari Rachmawati2
  • Udin Bahrudin3
  • N.S. Widyastiti2
  • Dwi Retnoningrum2
  1. 1Doctoral study Program of Medical and Health Science, Faculty of Medicine, Diponegoro University, Indonesia
  2. 2Department of Clinical Pathology, Faculty of Medicine, Diponegoro University, Indonesia
  3. 3Department of Cardiology and Vascular Medicine, Faculty of Medicine, Diponegoro University, Indonesia
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Abstract

Background: Routine platelet indices reflect platelet size and turnover, whereas soluble vascular cell adhesion molecule-1 (sVCAM-1) reflects endothelial activation. Whether these inexpensive indices relate to circulating VCAM-1 in coronary artery disease (CAD) is unclear.

Objective: To evaluate the association between platelet indices and sVCAM-1 in patients with CAD.

Methods: This cross-sectional study consecutively enrolled 80 patients with stable, angiographically confirmed CAD (>50% stenosis in at least one major coronary artery) at Dr. Kariadi General Hospital, Semarang, Indonesia. Platelet count, mean platelet volume (MPV), platelet large cell ratio (P-LCR) and large-platelet count were measured with a Sysmex XN-1000 analyser, and serum sVCAM-1 by sandwich ELISA (Elabscience). Spearman correlation and multivariable linear regression were used.

Results: Platelet count (ρ = 0.24, p = 0.036) and large-platelet count (ρ = 0.35, p = 0.002) were weakly correlated with sVCAM-1 (344.23 ± 144.98 ng/mL), whereas MPV (ρ = 0.10, p = 0.387) and P-LCR (ρ = 0.11, p = 0.336) were not. After adjustment for clinical covariates, only large-platelet count remained associated with sVCAM-1 (β = 58.7 ng/mL per SD; 95% CI 23.4–94.1; p = 0.002).

Conclusion: In stable CAD, large-platelet count and, less robustly, platelet count, but not MPV or P-LCR, were weakly associated with sVCAM-1. These hypothesis-generating findings require confirmation in larger prospective studies.

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Cite

BibTeXRIS
BibTeX
@article{ariosta2026association,
  title = {{Association between platelet indices and VCAM-1 levels in patients with coronary artery disease}},
  author = {Ariosta and Banundari Rachmawati and Udin Bahrudin and N.S. Widyastiti and Dwi Retnoningrum},
  journal = {American Heart Journal Plus: Cardiology Research and Practice},
  year = {2026},
  month = oct,
  doi = {10.1016/j.ahjo.2026.100960},
  url = {https://doi.org/10.1016/j.ahjo.2026.100960},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Association between platelet indices and VCAM-1 levels in patients with coronary artery disease
AU  - Ariosta
AU  - Banundari Rachmawati
AU  - Udin Bahrudin
AU  - N.S. Widyastiti
AU  - Dwi Retnoningrum
PY  - 2026
DA  - 2026/10/14
JO  - American Heart Journal Plus: Cardiology Research and Practice
DO  - 10.1016/j.ahjo.2026.100960
UR  - https://doi.org/10.1016/j.ahjo.2026.100960
AB  - Background: Routine platelet indices reflect platelet size and turnover, whereas soluble vascular cell adhesion molecule-1 (sVCAM-1) reflects endothelial activation. Whether these inexpensive indices relate to circulating VCAM-1 in coronary artery disease (CAD) is unclear.  Objective: To evaluate the association between platelet indices and sVCAM-1 in patients with CAD.  Methods: This cross-sectional study consecutively enrolled 80 patients with stable, angiographically confirmed CAD (>50% stenosis in at least one major coronary artery) at Dr. Kariadi General Hospital, Semarang, Indonesia. Platelet count, mean platelet volume (MPV), platelet large cell ratio (P-LCR) and large-platelet count were measured with a Sysmex XN-1000 analyser, and serum sVCAM-1 by sandwich ELISA (Elabscience). Spearman correlation and multivariable linear regression were used.  Results: Platelet count (ρ = 0.24, p = 0.036) and large-platelet count (ρ = 0.35, p = 0.002) were weakly correlated with sVCAM-1 (344.23 ± 144.98 ng/mL), whereas MPV (ρ = 0.10, p = 0.387) and P-LCR (ρ = 0.11, p = 0.336) were not. After adjustment for clinical covariates, only large-platelet count remained associated with sVCAM-1 (β = 58.7 ng/mL per SD; 95% CI 23.4–94.1; p = 0.002).  Conclusion: In stable CAD, large-platelet count and, less robustly, platelet count, but not MPV or P-LCR, were weakly associated with sVCAM-1. These hypothesis-generating findings require confirmation in larger prospective studies.
SN  - 2666-6022
ER  -