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Peer-reviewedCC BYmédecine/sciences

Le métabolisme du tryptophane : un acteur clé des maladies cardiométaboliques

  • Mouna Chajadine1
  • Ludivine Laurans1
  • Soraya Taleb1
  1. 1Université Paris Cité, Inserm U970, Centre de recherche cardiovasculaire (PARCC), Hôpital européen Georges Pompidou
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Abstract

Tryptophan (Trp), an essential amino acid, plays a central role in metabolism, inflammation, immunity, and energy homeostasis. It is primarily metabolized through the kynurenine, indole, and serotonin pathways, generating metabolites with either protective or harmful effects depending on the physiological and tissue context. Dysregulation of these pathways contributes to obesity, diabetes, and cardiovascular diseases. Understanding these mechanisms paves the way for personalized nutritional and therapeutic strategies to prevent and manage cardiometabolic diseases.

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Cite

BibTeXRIS
BibTeX
@article{chajadine2026métabolisme,
  title = {{Le métabolisme du tryptophane : un acteur clé des maladies cardiométaboliques}},
  author = {Mouna Chajadine and Ludivine Laurans and Soraya Taleb},
  journal = {médecine/sciences},
  year = {2026},
  month = jun,
  doi = {10.1051/medsci/2026094},
  url = {https://doi.org/10.1051/medsci/2026094},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Le métabolisme du tryptophane : un acteur clé des maladies cardiométaboliques
AU  - Mouna Chajadine
AU  - Ludivine Laurans
AU  - Soraya Taleb
PY  - 2026
DA  - 2026/06/01
JO  - médecine/sciences
DO  - 10.1051/medsci/2026094
UR  - https://doi.org/10.1051/medsci/2026094
AB  - Tryptophan (Trp), an essential amino acid, plays a central role in metabolism, inflammation, immunity, and energy homeostasis. It is primarily metabolized through the kynurenine, indole, and serotonin pathways, generating metabolites with either protective or harmful effects depending on the physiological and tissue context. Dysregulation of these pathways contributes to obesity, diabetes, and cardiovascular diseases. Understanding these mechanisms paves the way for personalized nutritional and therapeutic strategies to prevent and manage cardiometabolic diseases.
SN  - 0767-0974
SN  - 1958-5381
ER  -