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Peer-reviewedLicence not statedNew England Journal of Medicine

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease

  • Nima Gharahdaghi1,2
  • Pai‐Jui Yeh1,2
  • Lourdes Ceron‐Gutierrez3
  • H Griffin4
  • Hannah Gordon2
  • Chamara Jayamanne5
  • Alice Fracchia6
  • Amanda Yoon-Yee Chong1
  • Alissa Walsh2
  • Oliver Brain2
  • Katherine Baker7
  • Hannah Kockelbergh8
38 more authors
  • Yang Luo8
  • Martha Guevara Becerra1
  • Katherine Vadakethala1
  • Madeleine Coy1
  • Ladan Kabiri1
  • Martin Barnardo9
  • Susanna Jane Dunachie10
  • Barbara Kronsteiner10
  • Anna Adams2
  • Darren J. Fowler11
  • Qian Zhang12
  • Laura Fachal12
  • Carl A. Anderson12
  • Rofaida Desoki13,12
  • Marie Vibeke Vestergaard6
  • Lone Larsen14,6
  • Nicola J Wyatt15,4
  • Robert D. Lees15,4
  • Robert J Mulligan15,4
  • Chaonan Dong15,4
  • Mohmmed Tauseef Sharip13
  • Sian Elizabeth Faustini16
  • Adrian Matthew Shields16
  • Julia Pakpoor8
  • Bushra Naz1
  • Alex Richter16
  • Jack Satsangi1
  • Christopher A. Lamb15,4,17
  • Miles Parkes13,18
  • Fiona M. Powrie8
  • Alexander J. Mentzer1,19
  • Aleksejs Sazonovs6
  • Tine Jess14,6
  • Paul Klenerman20,2
  • Simon P.L. Travis8,20,2
  • Sophie Hambleton21,4
  • Rainer Döffinger3,18
  • Holm H. Uhlig1,22,20,2
22 affiliations
  1. 1Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
  2. 2Translational Gastroenterology and Liver Unit, University of Oxford, Oxford, United Kingdom
  3. 3Department of Clinical Biochemistry and Immunology, Cambridge University Hospital, Cambridge, United Kingdom
  4. 4Immunity and Inflammation Theme, Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, United Kingdom
  5. 5Oxford University Children’s Hospital NHS Foundation Trust, Oxford, United Kingdom
  6. 6National Center of Excellence for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Faculty of Medicine, Aalborg University, Aalborg, Denmark
  7. 7Department of Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
  8. 8Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom
  9. 9Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
  10. 10NDM Centre for Global Health Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
  11. 11Department of Pathology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom
  12. 12Genomics of Inflammation and Immunity Group, Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom
  13. 13Cambridge University Hospitals, Cambridge, United Kingdom
  14. 14Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark
  15. 15Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
  16. 16Clinical Immunology Services, University of Birmingham, Birmingham, United Kingdom
  17. 17National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre, Newcastle upon Tyne, United Kingdom
  18. 18NIHR Cambridge Biomedical Research Centre, Cambridge, United Kingdom
  19. 19Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, United Kingdom
  20. 20NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom
  21. 21Great North Children’s Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
  22. 22Department of Pediatrics, University of Oxford, Oxford, United Kingdom
Open at sourceDOICite

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Cite

BibTeXRIS
BibTeX
@article{gharahdaghi2026interleukin10,
  title = {{Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease}},
  author = {Nima Gharahdaghi and Pai‐Jui Yeh and Lourdes Ceron‐Gutierrez and H Griffin and Hannah Gordon and Chamara Jayamanne and Alice Fracchia and Amanda Yoon-Yee Chong and Alissa Walsh and Oliver Brain and Katherine Baker and Hannah Kockelbergh and Yang Luo and Martha Guevara Becerra and Katherine Vadakethala and Madeleine Coy and Ladan Kabiri and Martin Barnardo and Susanna Jane Dunachie and Barbara Kronsteiner and Anna Adams and Darren J. Fowler and Qian Zhang and Laura Fachal and Carl A. Anderson and Rofaida Desoki and Marie Vibeke Vestergaard and Lone Larsen and Nicola J Wyatt and Robert D. Lees and Robert J Mulligan and Chaonan Dong and Mohmmed Tauseef Sharip and Sian Elizabeth Faustini and Adrian Matthew Shields and Julia Pakpoor and Bushra Naz and Alex Richter and Jack Satsangi and Christopher A. Lamb and Miles Parkes and Fiona M. Powrie and Alexander J. Mentzer and Aleksejs Sazonovs and Tine Jess and Paul Klenerman and Simon P.L. Travis and Sophie Hambleton and Rainer Döffinger and Holm H. Uhlig},
  journal = {New England Journal of Medicine},
  year = {2026},
  month = jun,
  doi = {10.1056/nejmoa2513654},
  url = {https://research.birmingham.ac.uk/en/publications/f68b3f0c-bff9-4e5a-a5b6-65c112b2c34a},
}
RIS
TY  - JOUR
TI  - Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease
AU  - Nima Gharahdaghi
AU  - Pai‐Jui Yeh
AU  - Lourdes Ceron‐Gutierrez
AU  - H Griffin
AU  - Hannah Gordon
AU  - Chamara Jayamanne
AU  - Alice Fracchia
AU  - Amanda Yoon-Yee Chong
AU  - Alissa Walsh
AU  - Oliver Brain
AU  - Katherine Baker
AU  - Hannah Kockelbergh
AU  - Yang Luo
AU  - Martha Guevara Becerra
AU  - Katherine Vadakethala
AU  - Madeleine Coy
AU  - Ladan Kabiri
AU  - Martin Barnardo
AU  - Susanna Jane Dunachie
AU  - Barbara Kronsteiner
AU  - Anna Adams
AU  - Darren J. Fowler
AU  - Qian Zhang
AU  - Laura Fachal
AU  - Carl A. Anderson
AU  - Rofaida Desoki
AU  - Marie Vibeke Vestergaard
AU  - Lone Larsen
AU  - Nicola J Wyatt
AU  - Robert D. Lees
AU  - Robert J Mulligan
AU  - Chaonan Dong
AU  - Mohmmed Tauseef Sharip
AU  - Sian Elizabeth Faustini
AU  - Adrian Matthew Shields
AU  - Julia Pakpoor
AU  - Bushra Naz
AU  - Alex Richter
AU  - Jack Satsangi
AU  - Christopher A. Lamb
AU  - Miles Parkes
AU  - Fiona M. Powrie
AU  - Alexander J. Mentzer
AU  - Aleksejs Sazonovs
AU  - Tine Jess
AU  - Paul Klenerman
AU  - Simon P.L. Travis
AU  - Sophie Hambleton
AU  - Rainer Döffinger
AU  - Holm H. Uhlig
PY  - 2026
DA  - 2026/06/10
JO  - New England Journal of Medicine
DO  - 10.1056/nejmoa2513654
UR  - https://research.birmingham.ac.uk/en/publications/f68b3f0c-bff9-4e5a-a5b6-65c112b2c34a
SN  - 0028-4793
SN  - 0096-6762
SN  - 1533-4406
SN  - 2331-4710
ER  -