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Peer-reviewedCC BY-NC-ND 4.0Acta Obstetricia et Gynecologica Scandinavica

Angiogenic biomarker concentrations and their relation to coronary atherosclerosis in women with a history of preeclampsia: Findings from the CPH‐PRECIOUS study

  • Signe Højstrup Bessing1
  • Maria Guldbrandt Hauge1
  • Jesper James Linde2
  • Marianne Johansen1
  • Anne Ersbøll1
  • Klaus Fuglsang Kofoed3,4
  • Andreas Fuchs2,5
  • Per Ejlstrup Sigvardsen2
  • Finn Gustafsson2,3
  • Mille Kirk3,6
  • Line Rode3,6
  • Peter Damm1,3
6 affiliations
  1. 1Department of Gynaecology, Fertility and Obstetrics, Juliane Marie Center Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark
  2. 2Department of Cardiology, The Heart Center Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark
  3. 3Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark
  4. 4Department of Cardiology and Radiology Copenhagen University Hospital Copenhagen Denmark
  5. 5Department of Cardiology Copenhagen University Hospital, Amager and Hvidovre Hvidovre Denmark
  6. 6Department of Clinical Biochemistry Rigshospitalet, Copenhagen University Hospital Copenhagen Denmark
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Abstract

Introduction: Preeclampsia is known to be associated with a two‐ to fourfold elevated risk of developing cardiovascular disease in the first 15 years following pregnancy. In this cross‐sectional study of 892 women with prior preeclampsia, we aimed to assess differences in circulating angiogenic biomarker concentrations according to CT‐assessed coronary atherosclerosis in women up to 28 years after an index pregnancy complicated by preeclampsia.

Material and Methods: Women were identified from clinical databases consisting of data from all deliveries within the Capital Region of Denmark from 1995 onwards. Women with prior preeclampsia and a current age between 35 and 55 years were included from the CPH‐PRECIOUS cohort. The primary outcome was differences in circulating angiogenic biomarkers according to CT‐assessed coronary atherosclerosis.

Results: The median time since the pregnancy complicated by preeclampsia was 12.5 years (range: 0–28 years). PlGF concentrations were significantly higher in women with coronary atherosclerosis (9.6 pg/mL [IQR 4.9–12.6] vs. 7.4 pg/mL [IQR 3.9–11.3], p = 0.001), and subsequently a lower calculated sFlt‐1/PlGF ratio (4.2 [IQR 3.1–6.3] vs. 5.0 [IQR 3.6–6.9], p = 0.001) was found. No differences in sFlt‐1 concentrations were observed. Higher PlGF concentrations were significantly associated with coronary atherosclerosis; however, associations were attenuated in adjusted analysis.

Conclusions: This is the first large study to investigate long‐term differences in circulating angiogenic biomarker concentrations after preeclampsia, highlighting the complex relationship between angiogenic biomarkers, preeclampsia, and later atherosclerotic burden.

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Cite

BibTeXRIS
BibTeX
@article{bessing2026angiogenic,
  title = {{Angiogenic biomarker concentrations and their relation to coronary atherosclerosis in women with a history of preeclampsia: Findings from the CPH‐PRECIOUS study}},
  author = {Signe Højstrup Bessing and Maria Guldbrandt Hauge and Jesper James Linde and Marianne Johansen and Anne Ersbøll and Klaus Fuglsang Kofoed and Andreas Fuchs and Per Ejlstrup Sigvardsen and Finn Gustafsson and Mille Kirk and Line Rode and Peter Damm},
  journal = {Acta Obstetricia et Gynecologica Scandinavica},
  year = {2026},
  month = jul,
  doi = {10.1111/aogs.70322},
  url = {https://doi.org/10.1111/aogs.70322},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Angiogenic biomarker concentrations and their relation to coronary atherosclerosis in women with a history of preeclampsia: Findings from the CPH‐PRECIOUS study
AU  - Signe Højstrup Bessing
AU  - Maria Guldbrandt Hauge
AU  - Jesper James Linde
AU  - Marianne Johansen
AU  - Anne Ersbøll
AU  - Klaus Fuglsang Kofoed
AU  - Andreas Fuchs
AU  - Per Ejlstrup Sigvardsen
AU  - Finn Gustafsson
AU  - Mille Kirk
AU  - Line Rode
AU  - Peter Damm
PY  - 2026
DA  - 2026/07/29
JO  - Acta Obstetricia et Gynecologica Scandinavica
DO  - 10.1111/aogs.70322
UR  - https://doi.org/10.1111/aogs.70322
AB  - Introduction: Preeclampsia is known to be associated with a two‐ to fourfold elevated risk of developing cardiovascular disease in the first 15 years following pregnancy. In this cross‐sectional study of 892 women with prior preeclampsia, we aimed to assess differences in circulating angiogenic biomarker concentrations according to CT‐assessed coronary atherosclerosis in women up to 28 years after an index pregnancy complicated by preeclampsia.  Material and Methods: Women were identified from clinical databases consisting of data from all deliveries within the Capital Region of Denmark from 1995 onwards. Women with prior preeclampsia and a current age between 35 and 55 years were included from the CPH‐PRECIOUS cohort. The primary outcome was differences in circulating angiogenic biomarkers according to CT‐assessed coronary atherosclerosis.  Results: The median time since the pregnancy complicated by preeclampsia was 12.5 years (range: 0–28 years). PlGF concentrations were significantly higher in women with coronary atherosclerosis (9.6 pg/mL [IQR 4.9–12.6] vs. 7.4 pg/mL [IQR 3.9–11.3], p = 0.001), and subsequently a lower calculated sFlt‐1/PlGF ratio (4.2 [IQR 3.1–6.3] vs. 5.0 [IQR 3.6–6.9], p = 0.001) was found. No differences in sFlt‐1 concentrations were observed. Higher PlGF concentrations were significantly associated with coronary atherosclerosis; however, associations were attenuated in adjusted analysis.  Conclusions: This is the first large study to investigate long‐term differences in circulating angiogenic biomarker concentrations after preeclampsia, highlighting the complex relationship between angiogenic biomarkers, preeclampsia, and later atherosclerotic burden.
SN  - 0001-6349
SN  - 1600-0412
ER  -