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Peer-reviewedCC BYRSC Mechanochemistry

Mechanochemistry-promoted Cu-catalyzed deoxygenative amination of O-alkylisourea

  • Yuntian Shi1
  • Wangzhe Chen1
  • Jing Liu1
  • Zhen Wang1
  • Xian Zhang1
  • Heyin Li1
  • Chao Sun1
  • Chen Xing1
  • Zhenlei Zou2
  • Weigang Zhang1
  • Yi Wang1
  1. 1aState Key Laboratory of Coordination Chemistry, Engineering Research Center of Photoresist Materials Ministry of Education, School of Chemistry, Nanjing University, Nanjing 210023, China.
  2. 2aState Key Laboratory of Coordination Chemistry, Engineering Research Center of Photoresist Materials Ministry of Education, School of Chemistry, Nanjing University, Nanjing 210023, China.bAnHui Technology Research Center of Optoelectronic Technology Appliance, Biomimetic Energy Laboratory, School of Electrical Engineering, Tongling University, Tongling 244000, China.
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Abstract

We report a mechanochemical copper-catalyzed deoxygenative amination of alcohols via O-alkylisourea intermediates under ball-milling. This one-pot method accelerates conversion, tolerates primary, secondary, and challenging tertiary alcohols, and enables late-stage functionalization and scalable drug synthesis, providing a versatile C(sp3)–N bond-forming platform.

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Cite

BibTeXRIS
BibTeX
@article{shi2026mechanochemistrypromoted,
  title = {{Mechanochemistry-promoted Cu-catalyzed deoxygenative amination of O-alkylisourea}},
  author = {Yuntian Shi and Wangzhe Chen and Jing Liu and Zhen Wang and Xian Zhang and Heyin Li and Chao Sun and Chen Xing and Zhenlei Zou and Weigang Zhang and Yi Wang},
  journal = {RSC Mechanochemistry},
  year = {2026},
  month = oct,
  doi = {10.1039/d6mr00094k},
  url = {https://doi.org/10.1039/d6mr00094k},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Mechanochemistry-promoted Cu-catalyzed deoxygenative amination of O-alkylisourea
AU  - Yuntian Shi
AU  - Wangzhe Chen
AU  - Jing Liu
AU  - Zhen Wang
AU  - Xian Zhang
AU  - Heyin Li
AU  - Chao Sun
AU  - Chen Xing
AU  - Zhenlei Zou
AU  - Weigang Zhang
AU  - Yi Wang
PY  - 2026
DA  - 2026/10/01
JO  - RSC Mechanochemistry
DO  - 10.1039/d6mr00094k
UR  - https://doi.org/10.1039/d6mr00094k
AB  - We report a mechanochemical copper-catalyzed deoxygenative amination of alcohols via O-alkylisourea intermediates under ball-milling. This one-pot method accelerates conversion, tolerates primary, secondary, and challenging tertiary alcohols, and enables late-stage functionalization and scalable drug synthesis, providing a versatile C(sp3)–N bond-forming platform.
SN  - 2976-8683
ER  -