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PreprintCC BY-NC-NDChemRxiv

Synthesis of Semisaturated Polycycles via a Microwave-Promoted Iminyl Radical Cascade Cyclization

  • Caleb J. Petersen1,2
  • Joshua D. Morgan1,2
  • Corbin D. Stratton1,2
  • Tanner A. Trejo1,2
  • Ethan P. Downing1,2
  • Jonathan J. Barker1,2
  • Steven L. Castle1,2
  1. 1Department of Chemistry and Biochemistry
  2. 2Brigham Young University
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Abstract

A microwave-promoted iminyl radical cascade cyclization that furnishes semisaturated polycycles is reported. Competitive reduction was suppressed by lowering the reaction concentration. The protocol is simple and tolerates a wide range of O -aryloxime substrates, with those bearing an electron-withdrawing group on the participating aryl ring performing the best. The modular substrate synthesis renders the process useful for constructing compound libraries.

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Cite

BibTeXRIS
BibTeX
@misc{petersen2026synthesis,
  title = {{Synthesis of Semisaturated Polycycles via a Microwave-Promoted Iminyl Radical Cascade Cyclization}},
  author = {Caleb J. Petersen and Joshua D. Morgan and Corbin D. Stratton and Tanner A. Trejo and Ethan P. Downing and Jonathan J. Barker and Steven L. Castle},
  howpublished = {ChemRxiv},
  year = {2026},
  month = sep,
  doi = {10.26434/chemrxiv.15009695/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009695/v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - UNPB
TI  - Synthesis of Semisaturated Polycycles via a Microwave-Promoted Iminyl Radical Cascade Cyclization
AU  - Caleb J. Petersen
AU  - Joshua D. Morgan
AU  - Corbin D. Stratton
AU  - Tanner A. Trejo
AU  - Ethan P. Downing
AU  - Jonathan J. Barker
AU  - Steven L. Castle
PY  - 2026
DA  - 2026/09/30
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15009695/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009695/v1
AB  - A microwave-promoted iminyl radical cascade cyclization that furnishes semisaturated polycycles is reported. Competitive reduction was suppressed by lowering the reaction concentration. The protocol is simple and tolerates a wide range of O -aryloxime substrates, with those bearing an electron-withdrawing group on the participating aryl ring performing the best. The modular substrate synthesis renders the process useful for constructing compound libraries.
ER  -