Clinical characteristics of postural tachycardia syndrome with and without hypermobile Ehlers-Danlos syndrome: a pilot study
4 affiliations
- 1Faculty of Medicine, Department of Neurology, University of Toyama
- 2Neuron-Glia Crosstalk Center, Graduate School of Medicine, Juntendo University
- 3Department of Medical Genetics, Shinshu University School of Medicine
- 4Department of Neurology, Takaoka Fushiki Hospital
Abstract
Background: The clinical characteristics of postural tachycardia syndrome patients with and without hypermobile Ehlers-Danlos syndrome remain unclear, particularly in the Japanese population. This study aimed to clarify the clinical features and laboratory findings of patients with postural tachycardia syndrome and hypermobile Ehlers-Danlos syndrome.
Methods: We retrospectively analyzed patients who presented with orthostatic intolerance at our hospital between April 2023 and July 2025. Of these, 21 patients were diagnosed with postural tachycardia syndrome using the head-up tilt test. The clinical features and test results of these patients were compared to those of patients with and without hypermobile Ehlers-Danlos syndrome.
Results: Of the 21 patients diagnosed with postural tachycardia syndrome, 4 were also found to have hypermobile Ehlers-Danlos syndrome. A significantly higher frequency of menstrual disorders was observed in the hypermobile Ehlers-Danlos syndrome group than in the non-hypermobile Ehlers-Danlos syndrome group (100% [4/4] vs. 23.1% [3/13], p = 0.015). Other clinical features and laboratory findings were similar between the groups.
Conclusion: These observations provide a rationale to hypothesize a possible contribution of connective tissue-related factors to disease progression. Larger studies are warranted to investigate whether a meaningful association exists between postural tachycardia syndrome and hypermobile Ehlers-Danlos syndrome.
Related
- Effectiveness of Individualized Physical Exercise in COVID-19-Induced Postural Orthostatic Tachycardia Syndrome.
- Overlapping Post-COVID Conditions: A Case of Myalgic Encephalomyelitis and Postural Orthostatic Tachycardia Syndrome Triggered by Sequential Epstein-Barr Virus (EBV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infections.
- Experiences of individually tailored physical exercise in COVID-19-induced postural orthostatic tachycardia syndrome: A qualitative content analysis
- Post-translational modifications in the insoluble fraction of platelet-poor plasma distinguish pre-COVID-19 Postural Orthostatic Tachycardia Syndrome, Long COVID, and Long COVID-POTS: a preliminary study.
- A trial of exosome rich stem cell secretome as a potential treatment for Hypermobile Ehlers-Danlos Syndrome
BibTeX
@article{hirosawa2026clinical,
title = {{Clinical characteristics of postural tachycardia syndrome with and without hypermobile Ehlers-Danlos syndrome: a pilot study}},
author = {Hiroaki Hirosawa and Shunya Nakane and Shuhei Takasawa and Risako Furuta and Hiroki Maesaka and Taichi Mitsui and Ryo Tanaka and Noriyuki Matsuda and Ryoko Shibuya and Mamoru Yamamoto and Tomohiro Hayashi and Takamasa Nukui and Tomoki Kosho and Yuji Nakatsuji and Toru Yamashita},
journal = {Frontiers in Neurology},
year = {2026},
month = nov,
doi = {10.3389/fneur.2026.1948115},
url = {https://www.frontiersin.org/articles/10.3389/fneur.2026.1948115/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Clinical characteristics of postural tachycardia syndrome with and without hypermobile Ehlers-Danlos syndrome: a pilot study
AU - Hiroaki Hirosawa
AU - Shunya Nakane
AU - Shuhei Takasawa
AU - Risako Furuta
AU - Hiroki Maesaka
AU - Taichi Mitsui
AU - Ryo Tanaka
AU - Noriyuki Matsuda
AU - Ryoko Shibuya
AU - Mamoru Yamamoto
AU - Tomohiro Hayashi
AU - Takamasa Nukui
AU - Tomoki Kosho
AU - Yuji Nakatsuji
AU - Toru Yamashita
PY - 2026
DA - 2026/11/03
JO - Frontiers in Neurology
DO - 10.3389/fneur.2026.1948115
UR - https://www.frontiersin.org/articles/10.3389/fneur.2026.1948115/full
AB - Background: The clinical characteristics of postural tachycardia syndrome patients with and without hypermobile Ehlers-Danlos syndrome remain unclear, particularly in the Japanese population. This study aimed to clarify the clinical features and laboratory findings of patients with postural tachycardia syndrome and hypermobile Ehlers-Danlos syndrome. Methods: We retrospectively analyzed patients who presented with orthostatic intolerance at our hospital between April 2023 and July 2025. Of these, 21 patients were diagnosed with postural tachycardia syndrome using the head-up tilt test. The clinical features and test results of these patients were compared to those of patients with and without hypermobile Ehlers-Danlos syndrome. Results: Of the 21 patients diagnosed with postural tachycardia syndrome, 4 were also found to have hypermobile Ehlers-Danlos syndrome. A significantly higher frequency of menstrual disorders was observed in the hypermobile Ehlers-Danlos syndrome group than in the non-hypermobile Ehlers-Danlos syndrome group (100% [4/4] vs. 23.1% [3/13], p = 0.015). Other clinical features and laboratory findings were similar between the groups. Conclusion: These observations provide a rationale to hypothesize a possible contribution of connective tissue-related factors to disease progression. Larger studies are warranted to investigate whether a meaningful association exists between postural tachycardia syndrome and hypermobile Ehlers-Danlos syndrome.
SN - 1664-2295
ER -