TNF rs1800629 Genotype and Motor Response to Intensive Rehabilitation in Parkinson’s Disease: An Exploratory Study
- 1IRCCS Fondazione Don Carlo Gnocchi ETS, 20148 Milan, Italy
- 2Pathophysiology and Transplantation Department, University of Milan, 20122 Milan, Italy
- 3Neurology Unit, Azienda Ospedaliero-Universitaria, 09042 Cagliari, Italy
Abstract
Rehabilitation is a key component of Parkinson’s disease (PD) management, although individual responses differ substantially. Genetic factors involved in neuroplasticity and inflammation may contribute to this variability. We investigated whether selected polymorphisms in inflammation- and neuroplasticity-related genes influence motor outcomes following intensive multidisciplinary rehabilitation in patients with PD. Sixty-six patients with a diagnosis of idiopathic PD were consecutively enrolled and randomly allocated to an intensive multidisciplinary rehabilitation group (EXP-Group, n = 34) or a home-based stretching control group (CTRL-Group, n = 32) for six weeks. MDS-UPDRS III score was assessed at baseline (T0) and post-treatment (T1). SNPs in the TNF, IL6, IL6R, IL1A, IL1B, IL10 and BDNF genes were genotyped. Possible associations between genotype, treatment group and MDS-UPDRS III score at T1 were analyzed using ANCOVA and linear mixed-effects models, adjusting for baseline MDS-UPDRS III score, age, sex, disease duration and levodopa equivalent daily dose (LEDD). A significant treatment group x TNF rs1800629 genotype interaction was observed (p = 0.033). Among EXP-Group patients, GG homozygotes showed lower adjusted MDS-UPDRS III scores than did the A-allele carriers (29.10 vs. 36.11; p = 0.029). Longitudinal analyses revealed a significant time × treatment group × TNF rs1800629 genotype interaction (p = 0.010), with GG homozygotes showing an approximately 10-point reduction in MDS-UPDRS III score (40.87 to 30.87; p < 0.001). These findings suggest that TNF rs1800629 contributes to variability in response to intensive multidisciplinary rehabilitation in PD.
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BibTeX
@article{agliardi2026rs1800629,
title = {{TNF rs1800629 Genotype and Motor Response to Intensive Rehabilitation in Parkinson’s Disease: An Exploratory Study}},
author = {Cristina Agliardi and Franca Rosa Guerini and Elisabetta Bolognesi and Milena Zanzottera and Francesca Lea Saibene and Anna Salvatore and Pietro Arcuri and Anna Castagna and Davide Cattaneo and Thomas Bowman and Denise Anastasi and Jorge Navarro and Mario Meloni and Mario Clerici},
journal = {International Journal of Molecular Sciences},
year = {2026},
month = oct,
doi = {10.3390/ijms27219491},
url = {https://www.mdpi.com/1422-0067/27/21/9491},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - TNF rs1800629 Genotype and Motor Response to Intensive Rehabilitation in Parkinson’s Disease: An Exploratory Study
AU - Cristina Agliardi
AU - Franca Rosa Guerini
AU - Elisabetta Bolognesi
AU - Milena Zanzottera
AU - Francesca Lea Saibene
AU - Anna Salvatore
AU - Pietro Arcuri
AU - Anna Castagna
AU - Davide Cattaneo
AU - Thomas Bowman
AU - Denise Anastasi
AU - Jorge Navarro
AU - Mario Meloni
AU - Mario Clerici
PY - 2026
DA - 2026/10/24
JO - International Journal of Molecular Sciences
DO - 10.3390/ijms27219491
UR - https://www.mdpi.com/1422-0067/27/21/9491
AB - Rehabilitation is a key component of Parkinson’s disease (PD) management, although individual responses differ substantially. Genetic factors involved in neuroplasticity and inflammation may contribute to this variability. We investigated whether selected polymorphisms in inflammation- and neuroplasticity-related genes influence motor outcomes following intensive multidisciplinary rehabilitation in patients with PD. Sixty-six patients with a diagnosis of idiopathic PD were consecutively enrolled and randomly allocated to an intensive multidisciplinary rehabilitation group (EXP-Group, n = 34) or a home-based stretching control group (CTRL-Group, n = 32) for six weeks. MDS-UPDRS III score was assessed at baseline (T0) and post-treatment (T1). SNPs in the TNF, IL6, IL6R, IL1A, IL1B, IL10 and BDNF genes were genotyped. Possible associations between genotype, treatment group and MDS-UPDRS III score at T1 were analyzed using ANCOVA and linear mixed-effects models, adjusting for baseline MDS-UPDRS III score, age, sex, disease duration and levodopa equivalent daily dose (LEDD). A significant treatment group x TNF rs1800629 genotype interaction was observed (p = 0.033). Among EXP-Group patients, GG homozygotes showed lower adjusted MDS-UPDRS III scores than did the A-allele carriers (29.10 vs. 36.11; p = 0.029). Longitudinal analyses revealed a significant time × treatment group × TNF rs1800629 genotype interaction (p = 0.010), with GG homozygotes showing an approximately 10-point reduction in MDS-UPDRS III score (40.87 to 30.87; p < 0.001). These findings suggest that TNF rs1800629 contributes to variability in response to intensive multidisciplinary rehabilitation in PD.
SN - 1422-0067
ER -