Prediction models for venous thromboembolism in pediatric patients: A protocol for systematic review and critical appraisal
5 affiliations
- 1Department of Pediatrics, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People’s Hospital, Hubei Province, China
- 2Department of Traditional Chinese Medicine, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People’s Hospital, Hubei Province, China
- 3Department of Neonatal Intensive Care Unit, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People’s Hospital, Hubei Province, China
- 4Department of Nursing, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People’s Hospital, Hubei Province, China
- 5Department of Pediatric Outpatient, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People’s Hospital, Hubei Province, China
Abstract
Venous thromboembolism (VTE) in children is a severe disease with high mortality rates. It is also gradually recognized as a major source of morbidity in hospitalized children, leading to increased length of hospital stay, higher mortality, and increased costs. The majority of pediatric subjects with VTE present inherited or acquired risk factors,such as the use of a central venous catheter (CVC), which accounts for more than more than 90% of neonatal VTE and 50% of pediatric VTE. Clinical studies on predictive models for VTE in children have shown inconsistent results. This systematic review aims to evaluate published prediction models for pediatric VTE, analyzing their characteristics, predictors, efficacy, and the methodological quality and applicability. The protocol has been prepared using the Preferred Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) guidelines. The systematic review protocol for VTE prediction in pediatric patients has been registered on PROSPERO (PROSPERO 2025CRD420251231316. Available from https://www.crd.york.ac.uk/PROSPERO/vi-ew/CRD420251231316.) A comprehensive search across five major databases (PubMed, Web of Science, Cochrane Library, CNKI, and Wanfang) will be conducted for studies on prediction models of VTE among pediatric patients. Two researchers will independently screen literature, extract data, and evaluate the bias risk and applicability of included studies using prediction modelling study tools. This systematic review will provide critical insights into the efficacy and quality of reporting of the VTE model in pediatric patients. This will guide clinical physicians in selecting the most appropriate VTE prediction model and inform future research endeavors in pediatric VTE prediction.
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BibTeX
@article{liu2026prediction,
title = {{Prediction models for venous thromboembolism in pediatric patients: A protocol for systematic review and critical appraisal}},
author = {Huiqin Liu and Xiaojing Zhou and Zifeng Li and Wei Lu and Qianqian Ding and Zuyang Xi and Jingjing Yang},
journal = {PLOS One},
year = {2026},
month = nov,
doi = {10.1371/journal.pone.0361300},
url = {https://doi.org/10.1371/journal.pone.0361300},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Prediction models for venous thromboembolism in pediatric patients: A protocol for systematic review and critical appraisal
AU - Huiqin Liu
AU - Xiaojing Zhou
AU - Zifeng Li
AU - Wei Lu
AU - Qianqian Ding
AU - Zuyang Xi
AU - Jingjing Yang
PY - 2026
DA - 2026/11/04
JO - PLOS One
DO - 10.1371/journal.pone.0361300
UR - https://doi.org/10.1371/journal.pone.0361300
AB - Venous thromboembolism (VTE) in children is a severe disease with high mortality rates. It is also gradually recognized as a major source of morbidity in hospitalized children, leading to increased length of hospital stay, higher mortality, and increased costs. The majority of pediatric subjects with VTE present inherited or acquired risk factors,such as the use of a central venous catheter (CVC), which accounts for more than more than 90% of neonatal VTE and 50% of pediatric VTE. Clinical studies on predictive models for VTE in children have shown inconsistent results. This systematic review aims to evaluate published prediction models for pediatric VTE, analyzing their characteristics, predictors, efficacy, and the methodological quality and applicability. The protocol has been prepared using the Preferred Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) guidelines. The systematic review protocol for VTE prediction in pediatric patients has been registered on PROSPERO (PROSPERO 2025CRD420251231316. Available from https://www.crd.york.ac.uk/PROSPERO/vi-ew/CRD420251231316.) A comprehensive search across five major databases (PubMed, Web of Science, Cochrane Library, CNKI, and Wanfang) will be conducted for studies on prediction models of VTE among pediatric patients. Two researchers will independently screen literature, extract data, and evaluate the bias risk and applicability of included studies using prediction modelling study tools. This systematic review will provide critical insights into the efficacy and quality of reporting of the VTE model in pediatric patients. This will guide clinical physicians in selecting the most appropriate VTE prediction model and inform future research endeavors in pediatric VTE prediction.
SN - 1932-6203
ER -