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Peer-reviewedCC BY-NC 4.0Trends in pharmacological sciences

B cells enter the synaptic conversation

  • Terry R. Suk1,2
  • David Gate1,2
  1. 1Ken and Ruth Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
  2. 2Abrams Research Center on Neurogenomics, Northwestern University, Chicago, IL, USA
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Abstract

Synapse loss is a defining feature of neurodegenerative disease, yet the signals that orchestrate synaptic elimination remain incompletely understood. Crowley and colleagues uncover an unexpected link between neuronal hyperactivity and adaptive immunity, showing that antibody-secreting B cells and immunoglobulins can drive complement-dependent synapse loss.

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Cite

BibTeXRIS
BibTeX
@article{suk2026cells,
  title = {{B cells enter the synaptic conversation}},
  author = {Terry R. Suk and David Gate},
  journal = {Trends in pharmacological sciences},
  year = {2026},
  month = sep,
  doi = {10.1016/j.tips.2026.09.004},
  url = {https://doi.org/10.1016/j.tips.2026.09.004},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - B cells enter the synaptic conversation
AU  - Terry R. Suk
AU  - David Gate
PY  - 2026
DA  - 2026/09/23
JO  - Trends in pharmacological sciences
DO  - 10.1016/j.tips.2026.09.004
UR  - https://doi.org/10.1016/j.tips.2026.09.004
AB  - Synapse loss is a defining feature of neurodegenerative disease, yet the signals that orchestrate synaptic elimination remain incompletely understood. Crowley and colleagues uncover an unexpected link between neuronal hyperactivity and adaptive immunity, showing that antibody-secreting B cells and immunoglobulins can drive complement-dependent synapse loss.
SN  - 0165-6147
SN  - 1873-3735
ER  -