Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 7 min ago
Peer-reviewedLicence not statedNature Metabolism

Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons

  • Claire Gao1,2
  • Isabelle C. Geneve1,2
  • Shakira Rodriguez-Gonzalez1,2
  • Chia Li1,2
  • Kaitlyn McElhern1,2
  • Marc L. Reitman1,2
  • Andrew Lutas3,2
  • Michael J. Krashes4
4 affiliations
  1. 1Diabetes, Endocrinology, & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA
  2. 2Diabetes, Endocrinology, & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Disorders, Bethesda, MD, USA
  3. 3Diabetes, Endocrinology, & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. [email protected]
  4. 4Diabetes, Endocrinology, & Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. [email protected]
Open at sourcePDFDOICite

Related

  1. Semaglutide, Other GLP-1 Receptor Agonists, and Papillary Thyroid Carcinoma: A Narrative Review of Risk, Progression, and Mechanisms
    Luiza Barseghyan, Iqbal Munir, Steven Chrysafide +2
    Journal of Clinical MedicinePeer-reviewedCC BY 4.0Full textEndocrinology & metabolismCrossrefEurope PMC
  2. Claudin‐12‐Expressing Fibroblasts Facilitate Metastatic Spread of Pancreatic Cancer Through Physical Interactions
    Qingcui Li, Xiangjing Miao, Yuanyuan Yang +9
    MedCommPeer-reviewedCC BYFull textOncologyEurope PMCPMC
  3. Isogenic human stem cell models reveal mutation-dependent protective mechanisms of APOE3 Christchurch
    Carlye Frisch, Lauren Baker, Gayathri Srinivasan +5
    Frontiers in aging neurosciencePeer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. Bepirovirsen improves the functional cure of chronic hepatitis B through novel mechanisms.
    Qing-Lei Zeng, Junliang Fu
    Infectious diseases & immunityPeer-reviewedCC BY-NC-NDFull textEpidemiology & public healthEurope PMC
  5. Selinexor enhances temozolomide efficacy in glioblastoma through modulation of multiple resistance-associated mechanisms
    Beyza Ozturk, Asuman Celebi, Deniz Kilic +2
    Frontiers in oncologyPeer-reviewedCC BYFull textOncologyEurope PMC

Cite

BibTeXRIS
BibTeX
@article{gao2026semaglutide,
  title = {{Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons}},
  author = {Claire Gao and Isabelle C. Geneve and Shakira Rodriguez-Gonzalez and Chia Li and Kaitlyn McElhern and Marc L. Reitman and Andrew Lutas and Michael J. Krashes},
  journal = {Nature Metabolism},
  year = {2026},
  month = may,
  doi = {10.1038/s42255-026-01534-8},
  url = {https://doi.org/10.1101/2025.08.12.668772},
}
RIS
TY  - JOUR
TI  - Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons
AU  - Claire Gao
AU  - Isabelle C. Geneve
AU  - Shakira Rodriguez-Gonzalez
AU  - Chia Li
AU  - Kaitlyn McElhern
AU  - Marc L. Reitman
AU  - Andrew Lutas
AU  - Michael J. Krashes
PY  - 2026
DA  - 2026/05/22
JO  - Nature Metabolism
DO  - 10.1038/s42255-026-01534-8
UR  - https://doi.org/10.1101/2025.08.12.668772
SN  - 2522-5812
ER  -