Biomarkers for Post-Traumatic Headache in Youth.
- 1Department of Pediatrics, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA. [email protected].
- 2Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA. [email protected].
- 3Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
Abstract
Purpose of review
Traumatic brain injury is a highly prevalent condition impacting youth that commonly results in persist headache. However, current management is limited by our ability to differentiate youth who will recover with little intervention from those who will develop a potentially debilitating headache lasting months to years. The aim of this review is to highlight promising biomarkers for identifying youth who will develop persistent post-traumatic headache.Recent findings
Multiple candidate genetic, protein, imaging, electrophysiological, and digital biomarkers have been identified to help differentiate youth who will develop persistent headache from traumatic brain injury from those who will recover. Promising directions include biomarkers that overlap between traumatic brain injury and migraine. However, no biomarkers are ready for standard use in clinical care. While further work is needed to develop and validate clinically reliable biomarkers of post-traumatic headache in the pediatric population, myriad candidate biomarkers hold promise and warrant further study.
Related
- Post-traumatic headache as a window into persistent brain dysfunction after traumatic brain injury: an opinion article.
- Symptoms of autonomic dysfunction amongst those with acute post-traumatic headache due to mild traumatic brain injury
- From past to present and toward the future: a mechanism-informed clinical framework for COVID-19-associated headache and post-viral pain
- Fluid Biomarkers for the Antemortem Detection of Chronic Traumatic Encephalopathy: A Critical Review
- Continuous epidural saline infusion combined with intranasal dexmedetomidine for severe post-dural puncture headache with intracranial hypotension: a case report
BibTeX
@article{gentile2026biomarkers,
title = {{Biomarkers for Post-Traumatic Headache in Youth.}},
author = {Carlyn Patterson Gentile and Ramon Diaz-Arrastia},
journal = {Current pain and headache reports},
year = {2026},
month = oct,
doi = {10.1007/s11916-026-01571-8},
url = {https://europepmc.org/article/MED/42961764},
note = {CC BY},
}
RIS
TY - JOUR
TI - Biomarkers for Post-Traumatic Headache in Youth.
AU - Carlyn Patterson Gentile
AU - Ramon Diaz-Arrastia
PY - 2026
DA - 2026/10/30
JO - Current pain and headache reports
DO - 10.1007/s11916-026-01571-8
UR - https://europepmc.org/article/MED/42961764
AB - Purpose of review Traumatic brain injury is a highly prevalent condition impacting youth that commonly results in persist headache. However, current management is limited by our ability to differentiate youth who will recover with little intervention from those who will develop a potentially debilitating headache lasting months to years. The aim of this review is to highlight promising biomarkers for identifying youth who will develop persistent post-traumatic headache.Recent findings Multiple candidate genetic, protein, imaging, electrophysiological, and digital biomarkers have been identified to help differentiate youth who will develop persistent headache from traumatic brain injury from those who will recover. Promising directions include biomarkers that overlap between traumatic brain injury and migraine. However, no biomarkers are ready for standard use in clinical care. While further work is needed to develop and validate clinically reliable biomarkers of post-traumatic headache in the pediatric population, myriad candidate biomarkers hold promise and warrant further study.
SN - 1531-3433
SN - 1534-3081
ER -