Possible Relevance of Hepatoma-derived Growth Factor and Alkylglycerone Phosphate Synthase to Pancreatic Cancer Progression
- 1Department of Gastroenterology, Hyogo Medical University, Nishinomiya, Japan
Abstract
Background/Aim: We identified a new growth factor, hepatoma-derived growth factor (HDGF), and reported that its expression is associated with the prognosis of various cancer types, including pancreatic cancer. Recently, we determined that alkylglycerone phosphate synthase (AGPS) gene is a target of HDGF in hepatoma cells. Herein, we examined the possible involvement of HDGF and AGPS in pancreatic cancer progression.
Materials and Methods: The growth-promoting effect of HDGF on pancreatic cancer cells (Suit-2) was evaluated in vitro. Using the public database UCSC Xena, the expression of HDGF between normal and cancerous pancreatic tissues was compared. The relevance of the expression of HDGF to the prognosis of pancreatic cancer was assessed using two public cancer databases (UCSC Xena and Kaplan-Meier Plotter). The correlation between the expression of AGPS in pancreatic cancer tissue and the expression of HDGF was examined and the expression of AGPS between normal and cancerous pancreatic tissues compared. Furthermore, the association between the expression of AGPS and the prognosis of pancreatic cancer was examined.
Results: The administration of recombinant HDGF protein promoted in vitro pancreatic cancer cell proliferation. HDGF expression in pancreatic cancer tissues from patients was higher than that in normal pancreatic tissues. Additionally, two different databases revealed that high expression of HDGF was associated with a poor prognosis in patients with pancreatic cancer. The expression of AGPS was positively correlated with the HDGF expression in pancreatic cancer tissues. In addition to the expression of HDGF, the expression of AGPS in pancreatic cancer tissues was higher than that in normal pancreatic tissues and high expression of AGPS was associated with the poor prognosis of pancreatic cancer.
Conclusion: HDGF and AGPS are suggested to be involved in pancreatic cancer progression.
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BibTeX
@article{enomoto2026possible,
title = {{Possible Relevance of Hepatoma-derived Growth Factor and Alkylglycerone Phosphate Synthase to Pancreatic Cancer Progression}},
author = {HIRAYUKI ENOMOTO and RYOTA YOSHIOKA and YUKIHISA YURI and NOBUHIRO AIZAWA and TOMOKI DONKAI and NOBUHITO TOKURA and TOMOYUKI TAKASHIMA and NAOTO IKEDA and TAKASHI NISHIMURA and HIDEYUKI SHIOMI and SHINICHIRO SHINZAKI},
journal = {In Vivo},
year = {2026},
month = oct,
doi = {10.21873/invivo.14485},
url = {https://doi.org/10.21873/invivo.14485},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Possible Relevance of Hepatoma-derived Growth Factor and Alkylglycerone Phosphate Synthase to Pancreatic Cancer Progression
AU - HIRAYUKI ENOMOTO
AU - RYOTA YOSHIOKA
AU - YUKIHISA YURI
AU - NOBUHIRO AIZAWA
AU - TOMOKI DONKAI
AU - NOBUHITO TOKURA
AU - TOMOYUKI TAKASHIMA
AU - NAOTO IKEDA
AU - TAKASHI NISHIMURA
AU - HIDEYUKI SHIOMI
AU - SHINICHIRO SHINZAKI
PY - 2026
DA - 2026/10/29
JO - In Vivo
DO - 10.21873/invivo.14485
UR - https://doi.org/10.21873/invivo.14485
AB - Background/Aim: We identified a new growth factor, hepatoma-derived growth factor (HDGF), and reported that its expression is associated with the prognosis of various cancer types, including pancreatic cancer. Recently, we determined that alkylglycerone phosphate synthase (AGPS) gene is a target of HDGF in hepatoma cells. Herein, we examined the possible involvement of HDGF and AGPS in pancreatic cancer progression. Materials and Methods: The growth-promoting effect of HDGF on pancreatic cancer cells (Suit-2) was evaluated in vitro. Using the public database UCSC Xena, the expression of HDGF between normal and cancerous pancreatic tissues was compared. The relevance of the expression of HDGF to the prognosis of pancreatic cancer was assessed using two public cancer databases (UCSC Xena and Kaplan-Meier Plotter). The correlation between the expression of AGPS in pancreatic cancer tissue and the expression of HDGF was examined and the expression of AGPS between normal and cancerous pancreatic tissues compared. Furthermore, the association between the expression of AGPS and the prognosis of pancreatic cancer was examined. Results: The administration of recombinant HDGF protein promoted in vitro pancreatic cancer cell proliferation. HDGF expression in pancreatic cancer tissues from patients was higher than that in normal pancreatic tissues. Additionally, two different databases revealed that high expression of HDGF was associated with a poor prognosis in patients with pancreatic cancer. The expression of AGPS was positively correlated with the HDGF expression in pancreatic cancer tissues. In addition to the expression of HDGF, the expression of AGPS in pancreatic cancer tissues was higher than that in normal pancreatic tissues and high expression of AGPS was associated with the poor prognosis of pancreatic cancer. Conclusion: HDGF and AGPS are suggested to be involved in pancreatic cancer progression.
SN - 0258-851X
SN - 1791-7549
ER -