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Peer-reviewedCC BY 4.0The Febs Journal

ALOX15 links lipid metabolism to receptor trafficking in platelet activation

  • Yosef Eshetie Amare1,2
  • Sharad Saxena1
  • Serena Zacchigna1,3
  1. 1Cardiovascular Biology Laboratory International Centre for Genetic Engineering and Biotechnology (ICGEB) Trieste Italy
  2. 2Doctoral Study Programme of Molecular Genetics and Biotechnology, Gradute School University of Nova Gorica Nova Gorica Slovenia
  3. 3Department of Medicine, Surgery and Health Sciences University of Trieste Trieste Italy
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Abstract

Platelet activation is traditionally viewed as a signaling process initiated by receptor engagement. In this issue of The FEBS Journal, Govatati et al. identify an additional regulatory layer linking lipid metabolism to receptor trafficking. The authors show that ALOX15‐derived lipid mediators promote PKCθ‐NMT1‐dependent myristoylation of PAR4, thereby facilitating its membrane localization and platelet activation. These findings position receptor lipidation and trafficking as active regulatory mechanisms in platelet activation and suggest new opportunities for therapeutic modulation of hemostasis.

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Cite

BibTeXRIS
BibTeX
@article{amare2026alox15,
  title = {{ALOX15 links lipid metabolism to receptor trafficking in platelet activation}},
  author = {Yosef Eshetie Amare and Sharad Saxena and Serena Zacchigna},
  journal = {The Febs Journal},
  year = {2026},
  month = jun,
  doi = {10.1111/febs.70637},
  url = {https://doi.org/10.1111/febs.70637},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - ALOX15 links lipid metabolism to receptor trafficking in platelet activation
AU  - Yosef Eshetie Amare
AU  - Sharad Saxena
AU  - Serena Zacchigna
PY  - 2026
DA  - 2026/06/29
JO  - The Febs Journal
DO  - 10.1111/febs.70637
UR  - https://doi.org/10.1111/febs.70637
AB  - Platelet activation is traditionally viewed as a signaling process initiated by receptor engagement. In this issue of The FEBS Journal, Govatati et al. identify an additional regulatory layer linking lipid metabolism to receptor trafficking. The authors show that ALOX15‐derived lipid mediators promote PKCθ‐NMT1‐dependent myristoylation of PAR4, thereby facilitating its membrane localization and platelet activation. These findings position receptor lipidation and trafficking as active regulatory mechanisms in platelet activation and suggest new opportunities for therapeutic modulation of hemostasis.
SN  - 1742-464X
SN  - 1742-4658
ER  -