Polyphenols from the Root Barks of Ulmus davidiana var. japonica and Their Wound Healing Potential.
5 affiliations
- 1Department of Integrative Biological Sciences and Industry, Sejong University, 209 Neungdong-ro, Gwangjin-gu, Seoul 05006, Republic of Korea.
- 2School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea.
- 3Laboratory of Nuclear Magnetic Resonance, National Center for Inter-University Research Facilities (NCIRF), Seoul National University, Gwanak-gu, Seoul 08826, Republic of Korea.
- 4College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.
- 5Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Pusan National University, Busan 46241, Republic of Korea.
Abstract
The root bark of Ulmus davidiana var. japonica (Ulmaceae), commonly known as yugeunpi, has long been used in traditional Korean medicine to treat gastroenteric and inflammatory disorders, as well as to promote blood circulation and tissue regeneration. As part of our ongoing efforts to discover bioactive natural products from resources with pharmacological potential, a phytochemical investigation of the root bark of U. davidiana var. japonica was conducted, and the wound-healing potential of the isolated compounds was evaluated. This study led to the isolation of one new catechin glycoside derivative, (-)-catechinulmusol (1) and two new neolignan derivatives, neolignulmusides A and B (2 and 3), along with ten known compounds (4-13), including lignans (4 and 5), flavonoids (6-10), and phenolic derivatives (11-13). The structures of the new compounds (1-3) were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR, high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and chemical derivatization. Results from in vitro assays revealed that compounds 1, 4, 6, and 13 significantly promoted the migration of human skin keratinocytes. These findings suggest that these active compounds may serve as promising candidates for skin wound-healing applications, including epidermal regeneration.
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BibTeX
@article{yu2026polyphenols,
title = {{Polyphenols from the Root Barks of Ulmus davidiana var. japonica and Their Wound Healing Potential.}},
author = {Jae Sik Yu and Gakyung Lee and Sooyeon Kim and Yoon-Joo Ko and Min Cheol Kang and Sun Yeou Kim and Min Hye Yang and Ki Hyun Kim},
journal = {International journal of molecular sciences},
year = {2026},
month = sep,
doi = {10.3390/ijms27198630},
url = {https://europepmc.org/article/MED/42883877},
note = {CC BY},
}
RIS
TY - JOUR
TI - Polyphenols from the Root Barks of Ulmus davidiana var. japonica and Their Wound Healing Potential.
AU - Jae Sik Yu
AU - Gakyung Lee
AU - Sooyeon Kim
AU - Yoon-Joo Ko
AU - Min Cheol Kang
AU - Sun Yeou Kim
AU - Min Hye Yang
AU - Ki Hyun Kim
PY - 2026
DA - 2026/09/26
JO - International journal of molecular sciences
DO - 10.3390/ijms27198630
UR - https://europepmc.org/article/MED/42883877
AB - The root bark of Ulmus davidiana var. japonica (Ulmaceae), commonly known as yugeunpi, has long been used in traditional Korean medicine to treat gastroenteric and inflammatory disorders, as well as to promote blood circulation and tissue regeneration. As part of our ongoing efforts to discover bioactive natural products from resources with pharmacological potential, a phytochemical investigation of the root bark of U. davidiana var. japonica was conducted, and the wound-healing potential of the isolated compounds was evaluated. This study led to the isolation of one new catechin glycoside derivative, (-)-catechinulmusol (1) and two new neolignan derivatives, neolignulmusides A and B (2 and 3), along with ten known compounds (4-13), including lignans (4 and 5), flavonoids (6-10), and phenolic derivatives (11-13). The structures of the new compounds (1-3) were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR, high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and chemical derivatization. Results from in vitro assays revealed that compounds 1, 4, 6, and 13 significantly promoted the migration of human skin keratinocytes. These findings suggest that these active compounds may serve as promising candidates for skin wound-healing applications, including epidermal regeneration.
SN - 1422-0067
ER -