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Peer-reviewedCC BYFrontiers in Nutrition

Impact of Lactiplantibacillus plantarum UBLP-40 intervention on iron status indicators in iron-deficient women of reproductive age: a double-blind, randomized controlled trial

  • Mohamad Tarik1
  • Deepika Lina Minz1
  • Ritvik Amarchand2
  • Anand Krishnan2
  • Tushar Sehgal3
  • Mani Kalaivani4
  • Tulika Seth5
  • Jayanthi Neelamraju6
  • Ratna Sudha Madempudi6
  • Lakshmy Ramakrishnan1
6 affiliations
  1. 1Department of Cardiac Biochemistry, All India Institute of Medical Sciences, New Delhi, India
  2. 2Department of Community Medicine, All India Institute of Medical Sciences, New Delhi, India
  3. 3Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India
  4. 4Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India
  5. 5Department of Haematology, All India Institute of Medical Sciences, New Delhi, India
  6. 6Centre for Research & Development, Unique Biotech Ltd., Hyderabad, India
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Abstract

IntroductionIron deficiency remains highly prevalent among women of reproductive age due to increased physiological demands, inadequate dietary intake, and poor absorption. Conventional iron supplementation has shown limited success in addressing this issue. This study aimed to evaluate the effect of Lactiplantibacillus plantarum UBLP-40 (Lp40) on iron status indicators in iron-deficient women of reproductive age.MethodsIn this double-blind, randomized controlled trial, 152 iron-deficient women were randomized to receive either a probiotic-iron-ascorbic acid combination (Lp40-Fe-AA, n = 51), iron-ascorbic acid (Fe-AA, n = 50), or probiotic-iron (Lp40-Fe, n = 51) supplement in capsule form once daily, 1 hour before a meal for 12 weeks. Serum ferritin and other iron markers were measured at baseline, week 6, and week 12. Data were analyzed using a generalized linear mixed-effects model.ResultsA significant time-by-group interaction was found for inflammation-adjusted ferritin levels (p = 0.048). In post-hoc analysis, the Lp40-Fe-AA group showed significant improvement in serum ferritin compared to the Fe-AA group (10.33 ng/mL, 95% CI: 7.09–13.57 vs. 4.80 ng/mL, 95% CI: 1.93–7.66; p = 0.014) at 12 weeks. Ferritin levels did not show any significant difference when other groups were compared (Lp40-Fe-AA vs. Lp40-Fe, p = 0.485 and Lp40-Fe vs. Fe-AA, p = 0.076). No significant time-by-group interaction was however observed for hemoglobin, hepcidin, transferrin saturation, and reticulocyte indices.ConclusionThe results of this study indicate that L. plantarum UBLP-40 may offer a modest, but significant benefit when combined with iron and ascorbic acid. However, larger studies are required to validate these findings.Clinical Trial Registrationhttps://ctri.nic.in/Clinicaltrials/login.php, identifier CTRI/2021/03/032290.

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Cite

BibTeXRIS
BibTeX
@article{tarik2026impact,
  title = {{Impact of Lactiplantibacillus plantarum UBLP-40 intervention on iron status indicators in iron-deficient women of reproductive age: a double-blind, randomized controlled trial}},
  author = {Mohamad Tarik and Deepika Lina Minz and Ritvik Amarchand and Anand Krishnan and Tushar Sehgal and Mani Kalaivani and Tulika Seth and Jayanthi Neelamraju and Ratna Sudha Madempudi and Lakshmy Ramakrishnan},
  journal = {Frontiers in Nutrition},
  year = {2026},
  month = nov,
  doi = {10.3389/fnut.2026.1951057},
  url = {https://doi.org/10.3389/fnut.2026.1951057},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Impact of Lactiplantibacillus plantarum UBLP-40 intervention on iron status indicators in iron-deficient women of reproductive age: a double-blind, randomized controlled trial
AU  - Mohamad Tarik
AU  - Deepika Lina Minz
AU  - Ritvik Amarchand
AU  - Anand Krishnan
AU  - Tushar Sehgal
AU  - Mani Kalaivani
AU  - Tulika Seth
AU  - Jayanthi Neelamraju
AU  - Ratna Sudha Madempudi
AU  - Lakshmy Ramakrishnan
PY  - 2026
DA  - 2026/11/06
JO  - Frontiers in Nutrition
DO  - 10.3389/fnut.2026.1951057
UR  - https://doi.org/10.3389/fnut.2026.1951057
AB  - IntroductionIron deficiency remains highly prevalent among women of reproductive age due to increased physiological demands, inadequate dietary intake, and poor absorption. Conventional iron supplementation has shown limited success in addressing this issue. This study aimed to evaluate the effect of Lactiplantibacillus plantarum UBLP-40 (Lp40) on iron status indicators in iron-deficient women of reproductive age.MethodsIn this double-blind, randomized controlled trial, 152 iron-deficient women were randomized to receive either a probiotic-iron-ascorbic acid combination (Lp40-Fe-AA, n = 51), iron-ascorbic acid (Fe-AA, n = 50), or probiotic-iron (Lp40-Fe, n = 51) supplement in capsule form once daily, 1 hour before a meal for 12 weeks. Serum ferritin and other iron markers were measured at baseline, week 6, and week 12. Data were analyzed using a generalized linear mixed-effects model.ResultsA significant time-by-group interaction was found for inflammation-adjusted ferritin levels (p = 0.048). In post-hoc analysis, the Lp40-Fe-AA group showed significant improvement in serum ferritin compared to the Fe-AA group (10.33 ng/mL, 95% CI: 7.09–13.57 vs. 4.80 ng/mL, 95% CI: 1.93–7.66; p = 0.014) at 12 weeks. Ferritin levels did not show any significant difference when other groups were compared (Lp40-Fe-AA vs. Lp40-Fe, p = 0.485 and Lp40-Fe vs. Fe-AA, p = 0.076). No significant time-by-group interaction was however observed for hemoglobin, hepcidin, transferrin saturation, and reticulocyte indices.ConclusionThe results of this study indicate that L. plantarum UBLP-40 may offer a modest, but significant benefit when combined with iron and ascorbic acid. However, larger studies are required to validate these findings.Clinical Trial Registrationhttps://ctri.nic.in/Clinicaltrials/login.php, identifier CTRI/2021/03/032290.
SN  - 2296-861X
ER  -