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Peer-reviewedCC BYBMJ open

A randomised, placebo-controlled study to assess whether antibiotic-mediated disruption of the gut microbiota impairs BCG-induced specific and non-specific immunity in young, healthy adults: protocol for the Antibiotics and Vaccine Immune Responses Study (AVIRS).

  • Natalie E Stevens1,2
  • Rochelle Botten3
  • James B Geake4,5,6
  • Georgina L Eden1
  • Wing Ki Lo1
  • Joseph Inauen4
  • Jelena Solujic4
  • Alice Sawka4,5,6
  • Lisa N Yelland7,8
  • Elisabeth Wr Reid1,2
  • Michelle Shaw3
  • Xiaodan Zhu4,5
10 more authors
  • Tsz Kin Tam4,5
  • Hyejin Jeon4,5
  • Nelly Amenyogbe9
  • Miriam A Lynn1,2
  • Feargal J Ryan1,2
  • Carl G Feng10
  • Warwick J Britton11,12
  • Tobias R Kollmann9
  • Simone E Barry4,5,6
  • David J Lynn13,2
13 affiliations
  1. 1Systems Immunology Laboratory, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
  2. 2Flinders Health and Medical Research Institute (FHMRI), Flinders University College of Medicine and Public Health, Bedford Park, South Australia, Australia.
  3. 3Clinical Trials Platform, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
  4. 4Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
  5. 5South Australian Tuberculosis Service, Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
  6. 6Faculty of Health and Medical Sciences, Adelaide University, Adelaide, South Australia, Australia.
  7. 7SAHMRI Women and Kids, South Australian Health and Medical Research Institute, North Adelaide, South Australia, Australia.
  8. 8School of Public Health, Adelaide University, Adelaide, South Australia, Australia.
  9. 9Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.
  10. 10Immunology and Host Defence Group, The University of Sydney, Sydney, New South Wales, Australia.
  11. 11Centre for Infection and Immunity, Centenary Institute, Newtown, New South Wales, Australia.
  12. 12The University of Sydney Faculty of Medicine and Health, Sydney, New South Wales, Australia.
  13. 13Systems Immunology Laboratory, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia [email protected].
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Cite

BibTeXRIS
BibTeX
@article{stevens2026randomised,
  title = {{A randomised, placebo-controlled study to assess whether antibiotic-mediated disruption of the gut microbiota impairs BCG-induced specific and non-specific immunity in young, healthy adults: protocol for the Antibiotics and Vaccine Immune Responses Study (AVIRS).}},
  author = {Natalie E Stevens and Rochelle Botten and James B Geake and Georgina L Eden and Wing Ki Lo and Joseph Inauen and Jelena Solujic and Alice Sawka and Lisa N Yelland and Elisabeth Wr Reid and Michelle Shaw and Xiaodan Zhu and Tsz Kin Tam and Hyejin Jeon and Nelly Amenyogbe and Miriam A Lynn and Feargal J Ryan and Carl G Feng and Warwick J Britton and Tobias R Kollmann and Simone E Barry and David J Lynn},
  journal = {BMJ open},
  year = {2026},
  month = oct,
  doi = {10.1136/bmjopen-2026-126924},
  url = {https://europepmc.org/article/MED/42880793},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - A randomised, placebo-controlled study to assess whether antibiotic-mediated disruption of the gut microbiota impairs BCG-induced specific and non-specific immunity in young, healthy adults: protocol for the Antibiotics and Vaccine Immune Responses Study (AVIRS).
AU  - Natalie E Stevens
AU  - Rochelle Botten
AU  - James B Geake
AU  - Georgina L Eden
AU  - Wing Ki Lo
AU  - Joseph Inauen
AU  - Jelena Solujic
AU  - Alice Sawka
AU  - Lisa N Yelland
AU  - Elisabeth Wr Reid
AU  - Michelle Shaw
AU  - Xiaodan Zhu
AU  - Tsz Kin Tam
AU  - Hyejin Jeon
AU  - Nelly Amenyogbe
AU  - Miriam A Lynn
AU  - Feargal J Ryan
AU  - Carl G Feng
AU  - Warwick J Britton
AU  - Tobias R Kollmann
AU  - Simone E Barry
AU  - David J Lynn
PY  - 2026
DA  - 2026/10/14
JO  - BMJ open
DO  - 10.1136/bmjopen-2026-126924
UR  - https://europepmc.org/article/MED/42880793
SN  - 2044-6055
ER  -