Anesthetic challenges in a child with Alport syndrome undergoing prone surgery with a laryngeal mask airway: a case report
- 1Philipps-Universität Marburg, Marburg, Germany
- 2Department of Anesthesiology and Operative Intensive Care Medicine, University Hospital Giessen and Marburg, Campus Marburg, Marburg, Germany
- 3Department of Pediatric Anesthesia and Intensive Care Medicine, Klinikum Kassel, Kassel, Germany
Abstract
Introduction: Alport syndrome is a rare hereditary disorder caused by type IV collagen abnormalities and characterized by progressive kidney disease with variable extrarenal manifestations. Evidence guiding anesthetic management, particularly in pediatric patients, remains limited.
Case presentation: We report the anesthetic management of a 12-year-old girl with a clinical diagnosis of X-linked Alport syndrome based on microscopic hematuria and obligate heterozygosity for a familial pathogenic COL4A5 variant undergoing elective lower-leg surgery in the prone position. Despite preserved renal function, perioperative management included careful drug selection and a propofol-based total intravenous anesthesia using a second-generation laryngeal mask airway without neuromuscular blockade. Stable ventilation was maintained throughout prone surgery, and recovery was uncomplicated with effective postoperative pain control.
Conclusions: This case contributes to the limited literature on anesthetic management in pediatric Alport syndrome and highlights practical perioperative considerations regarding airway management, anesthetic technique, and renal-protective care.
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BibTeX
@article{gaik2026anesthetic,
title = {{Anesthetic challenges in a child with Alport syndrome undergoing prone surgery with a laryngeal mask airway: a case report}},
author = {Christine Gaik and Selena Knoth and Felix Schmitt and Ingelore Holzinger},
journal = {Frontiers in Pediatrics},
year = {2026},
month = oct,
doi = {10.3389/fped.2026.1950654},
url = {https://doi.org/10.3389/fped.2026.1950654},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Anesthetic challenges in a child with Alport syndrome undergoing prone surgery with a laryngeal mask airway: a case report
AU - Christine Gaik
AU - Selena Knoth
AU - Felix Schmitt
AU - Ingelore Holzinger
PY - 2026
DA - 2026/10/21
JO - Frontiers in Pediatrics
DO - 10.3389/fped.2026.1950654
UR - https://doi.org/10.3389/fped.2026.1950654
AB - Introduction: Alport syndrome is a rare hereditary disorder caused by type IV collagen abnormalities and characterized by progressive kidney disease with variable extrarenal manifestations. Evidence guiding anesthetic management, particularly in pediatric patients, remains limited. Case presentation: We report the anesthetic management of a 12-year-old girl with a clinical diagnosis of X-linked Alport syndrome based on microscopic hematuria and obligate heterozygosity for a familial pathogenic COL4A5 variant undergoing elective lower-leg surgery in the prone position. Despite preserved renal function, perioperative management included careful drug selection and a propofol-based total intravenous anesthesia using a second-generation laryngeal mask airway without neuromuscular blockade. Stable ventilation was maintained throughout prone surgery, and recovery was uncomplicated with effective postoperative pain control. Conclusions: This case contributes to the limited literature on anesthetic management in pediatric Alport syndrome and highlights practical perioperative considerations regarding airway management, anesthetic technique, and renal-protective care.
SN - 2296-2360
ER -