Nearly a century exploring oxylipins
Abstract
Oxylipin research has undergone a profound transformation since the first discovery of an oxygenated metabolite of fatty acid, evolving from the identification of enzymatically produced lipid mediators to the study of complex bioactive lipid networks. The discovery of numerous non-enzymatic oxidation products has considerably expanded the oxylipin landscape, while advances in organic synthesis have enabled their syntheses as well as their structural characterization, stereochemical assignment, and biological investigations. Concurrently, developments in mass spectrometry and lipidomics have revolutionized oxylipin analysis, allowing the comprehensive profiling of hundreds of metabolites in a single injection setting. More recently, molecular networking has shifted the focus from individual compounds to interconnected lipid networks. This review highlights the major milestones that have shaped the field and discusses emerging strategies integrating chemistry, biology, analytical science, and computational approaches to accelerate the discovery of new bioactive oxylipins. The convergence of these disciplines is expected to drive predictive lipidomics, network-guided discovery and synthesis, and the development of more sustainable synthetic strategies for identifying and engineering the next generation of bioactive lipid mediators.
Related
- Genetic Characterization of a 12th-Century Princely Burial in St. Sophia Cathedral of Veliky Novgorod.
- Using archaeometabolomics to characterise tobacco-usage in human cortical bone from 17th to 19th century Dutch communities
- Quantification of human DNA from century-old archived FFPE samples for retrospective genomic studies
- Exploring the conformational space of membrane protein folds matching distance constraints.
- Editorial: Exploring AI’s role in disease prediction and diagnosis through medical big data
BibTeX
@article{oger2026nearly,
title = {{Nearly a century exploring oxylipins}},
author = {Camille Oger and Jean-Marie Galano and Thierry Durand},
journal = {Comptes Rendus. Chimie},
year = {2026},
month = nov,
doi = {10.5802/crchim.485},
url = {https://hal.science/hal-05855627v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - Nearly a century exploring oxylipins
AU - Camille Oger
AU - Jean-Marie Galano
AU - Thierry Durand
PY - 2026
DA - 2026/11/04
JO - Comptes Rendus. Chimie
DO - 10.5802/crchim.485
UR - https://hal.science/hal-05855627v1
AB - Oxylipin research has undergone a profound transformation since the first discovery of an oxygenated metabolite of fatty acid, evolving from the identification of enzymatically produced lipid mediators to the study of complex bioactive lipid networks. The discovery of numerous non-enzymatic oxidation products has considerably expanded the oxylipin landscape, while advances in organic synthesis have enabled their syntheses as well as their structural characterization, stereochemical assignment, and biological investigations. Concurrently, developments in mass spectrometry and lipidomics have revolutionized oxylipin analysis, allowing the comprehensive profiling of hundreds of metabolites in a single injection setting. More recently, molecular networking has shifted the focus from individual compounds to interconnected lipid networks. This review highlights the major milestones that have shaped the field and discusses emerging strategies integrating chemistry, biology, analytical science, and computational approaches to accelerate the discovery of new bioactive oxylipins. The convergence of these disciplines is expected to drive predictive lipidomics, network-guided discovery and synthesis, and the development of more sustainable synthetic strategies for identifying and engineering the next generation of bioactive lipid mediators.
SN - 1631-0748
SN - 1878-1543
ER -