Research trends and knowledge structure of pancreatic cancer and type 2 diabetes mellitus research: a two-decade CiteSpace analysis
- 1Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine , ,
- 2School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine , ,
- 3School of Basic Medicine, Chengdu University of Traditional Chinese Medicine , ,
Abstract
Background: Pancreatic cancer and type 2 diabetes mellitus (T2DM) are closely linked through complex epidemiological and biological interactions. However, the development, knowledge structure, and research trends of this field have not been systematically characterized. This study aimed to investigate the research landscape and knowledge structure of pancreatic cancer and T2DM research from 2006 to 2025.
Methods: We conducted the primary bibliometric analysis using WOSCC records, and separately analyzed PubMed-indexed clinical trials as a supplementary dataset. A total of 1,989 WOSCC publications were included in the bibliometric analysis, while 54 PubMed-indexed Clinical Trial records were included in the supplementary clinical trial assessment. CiteSpace was used to perform collaboration, co-citation, keyword, timeline, and burst analyses of the WOSCC dataset.
Results: The number of publications increased steadily over the study period, particularly after 2015. The United States and China were the leading contributors, while the University of California System and Harvard University were among the most productive institutions. Major research themes included cancer risk, insulin resistance, metabolic inflammation, incretin-based therapies, and new-onset diabetes. Keyword evolution and burst analyses indicated increasing attention to mechanistic investigation, biomarker discovery, risk stratification, and precision medicine approaches.
Conclusion: This study characterizes the development and knowledge structure of research on the relationship between pancreatic cancer and T2DM and highlights major research themes, emerging hotspots, and future directions for mechanistic investigation and clinical translation.
Related
- Global trends and knowledge structure of cardiovascular magnetocardiography research: a bibliometric analysis
- Generating Implementation Research Knowledge for Scaling Lifestyle Modification Intervention to Control Hypertension and Diabetes: Lessons from the CoCo-HD Study in Kerala
- Knowledge evolution and emerging emphasis on outcome standardization in diabetes remission research: a multidatabase bibliometric analysis, 1950 to January 2026
- Bibliometric and visualized analysis of research trends and knowledge structure in novel pharmacological treatments for hypertrophic cardiomyopathy
- Research trends and knowledge structure of ferroptosis in hearing loss : A bibliometric analysis (2012–2026)
BibTeX
@article{dong2026research,
title = {{Research trends and knowledge structure of pancreatic cancer and type 2 diabetes mellitus research: a two-decade CiteSpace analysis}},
author = {Zilin Dong and Tingting Zhou and Shengwei Ma and Xuannan Chen and Yu Lai},
journal = {Frontiers in endocrinology},
year = {2026},
month = sep,
doi = {10.3389/fendo.2026.1945735},
url = {https://europepmc.org/article/PMC/PMC13661381},
note = {CC BY},
}
RIS
TY - JOUR
TI - Research trends and knowledge structure of pancreatic cancer and type 2 diabetes mellitus research: a two-decade CiteSpace analysis
AU - Zilin Dong
AU - Tingting Zhou
AU - Shengwei Ma
AU - Xuannan Chen
AU - Yu Lai
PY - 2026
DA - 2026/09/30
JO - Frontiers in endocrinology
DO - 10.3389/fendo.2026.1945735
UR - https://europepmc.org/article/PMC/PMC13661381
AB - Background: Pancreatic cancer and type 2 diabetes mellitus (T2DM) are closely linked through complex epidemiological and biological interactions. However, the development, knowledge structure, and research trends of this field have not been systematically characterized. This study aimed to investigate the research landscape and knowledge structure of pancreatic cancer and T2DM research from 2006 to 2025. Methods: We conducted the primary bibliometric analysis using WOSCC records, and separately analyzed PubMed-indexed clinical trials as a supplementary dataset. A total of 1,989 WOSCC publications were included in the bibliometric analysis, while 54 PubMed-indexed Clinical Trial records were included in the supplementary clinical trial assessment. CiteSpace was used to perform collaboration, co-citation, keyword, timeline, and burst analyses of the WOSCC dataset. Results: The number of publications increased steadily over the study period, particularly after 2015. The United States and China were the leading contributors, while the University of California System and Harvard University were among the most productive institutions. Major research themes included cancer risk, insulin resistance, metabolic inflammation, incretin-based therapies, and new-onset diabetes. Keyword evolution and burst analyses indicated increasing attention to mechanistic investigation, biomarker discovery, risk stratification, and precision medicine approaches. Conclusion: This study characterizes the development and knowledge structure of research on the relationship between pancreatic cancer and T2DM and highlights major research themes, emerging hotspots, and future directions for mechanistic investigation and clinical translation.
SN - 1664-2392
ER -