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Peer-reviewedCC BY 4.0Biomolecules

Retinol Stimulates Growth Factor Production and Extracellular Matrix-Related Marker Levels in Human Dermal Fibroblasts

  • Murat Türkoğlu1
  • Ali Türkan1
  • Gülistan Öncü1
  • Hakan Sevinç1
  • Erkin Pekmezci2
  1. 1R&D Center, Biota Laboratories, Sancaktepe, 34785 Istanbul, Türkiye
  2. 2Department of Dermatology, International Faculty of Medicine, Istanbul Medipol University, 34810 Istanbul, Türkiye
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Abstract

Retinol, a vitamin A derivative belonging to the retinoid family, is widely recognized for its anti-aging and wound-healing properties. In this study, we investigated the effects of retinol on the production of growth factors and major extracellular matrix (ECM) components in human dermal fibroblasts. Cells were treated with 0.05 and 0.5 μM retinol, and the levels of vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), transforming growth factor-beta (TGF-β), hyaluronan synthase-2 (HAS-2), collagen type-I (COL-I), and collagen type-III (COL-III) were quantified using ELISA. Retinol treatment significantly increased the levels of VEGF, FGF-2 and TGF-β at both concentrations tested. Similarly, the levels of the ECM-related markers HAS-2, COL-I and COL-III were elevated following retinol exposure at both concentrations. Collectively, these findings indicate that retinol induces a coordinated pro-regenerative response in human dermal fibroblasts, characterized by enhanced extracellular matrix production, angiogenic signaling, hyaluronic acid synthesis, and tissue remodeling. These results further support the role of retinol as an antiaging and wound healing agent that promotes skin regeneration and maintenance.

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Cite

BibTeXRIS
BibTeX
@article{turkoglu2026retinol,
  title = {{Retinol Stimulates Growth Factor Production and Extracellular Matrix-Related Marker Levels in Human Dermal Fibroblasts}},
  author = {Murat Türkoğlu and Ali Türkan and Gülistan Öncü and Hakan Sevinç and Erkin Pekmezci},
  journal = {Biomolecules},
  year = {2026},
  month = oct,
  doi = {10.3390/biom16101530},
  url = {https://www.mdpi.com/2218-273X/16/10/1530},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Retinol Stimulates Growth Factor Production and Extracellular Matrix-Related Marker Levels in Human Dermal Fibroblasts
AU  - Murat Türkoğlu
AU  - Ali Türkan
AU  - Gülistan Öncü
AU  - Hakan Sevinç
AU  - Erkin Pekmezci
PY  - 2026
DA  - 2026/10/01
JO  - Biomolecules
DO  - 10.3390/biom16101530
UR  - https://www.mdpi.com/2218-273X/16/10/1530
AB  - Retinol, a vitamin A derivative belonging to the retinoid family, is widely recognized for its anti-aging and wound-healing properties. In this study, we investigated the effects of retinol on the production of growth factors and major extracellular matrix (ECM) components in human dermal fibroblasts. Cells were treated with 0.05 and 0.5 μM retinol, and the levels of vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), transforming growth factor-beta (TGF-β), hyaluronan synthase-2 (HAS-2), collagen type-I (COL-I), and collagen type-III (COL-III) were quantified using ELISA. Retinol treatment significantly increased the levels of VEGF, FGF-2 and TGF-β at both concentrations tested. Similarly, the levels of the ECM-related markers HAS-2, COL-I and COL-III were elevated following retinol exposure at both concentrations. Collectively, these findings indicate that retinol induces a coordinated pro-regenerative response in human dermal fibroblasts, characterized by enhanced extracellular matrix production, angiogenic signaling, hyaluronic acid synthesis, and tissue remodeling. These results further support the role of retinol as an antiaging and wound healing agent that promotes skin regeneration and maintenance.
SN  - 2218-273X
ER  -