Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 1 h ago
Peer-reviewedCC BYFrontiers in public health

Association between adverse pregnancy outcomes and long-term postpartum blood pressure trajectories: a community-based cohort study.

  • Nan-Di Liu1,2
  • Li-Hua Chen3
  • Dan-Tong Wang1,2
  • Yi-Fan Wang1,2
  • Mei-Chen Yang4,5
  • Chang-Hao Zu3
  • Hong-Hong He3
  • Hong-Min Liu3
  • Li-Ming Lin3
  • Li-Xia Sun6
  • Xiao-Jia Xu7
  • Hai-Yan Zhao3
7 affiliations
  1. 1Kailuan General Hospital Affiliated with North China University of Science and Technology, Tangshan, China.
  2. 2North China University of Science and Technology, Tangshan, China.
  3. 3Department of Cardiology, Kailuan General Hospital, Tangshan, China.
  4. 4Hebei North University, Zhangjiakou, China.
  5. 5Kailuan General Hospital, Tangshan, China.
  6. 6Department of Emergency, Affiliated Hospital of North China University of Science and Technology, Tangshan, China.
  7. 7Department of Infection Control, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Read full textPDFDOICite

Abstract

Background

Adverse pregnancy outcomes (APOs) increase the future risk of hypertension, but their impact on long-term postpartum blood pressure (BP) trajectories remains unclear. We aimed to characterize these trajectories and compare trajectory membership between women with and without APOs.Methods

This community-based cohort study included 1,346 women with documented deliveries (2004-2020) from the Kailuan Study who underwent at least three postpartum health examinations between 2006 and 2022. APOs included hypertensive disorders of pregnancy (gestational hypertension and preeclampsia/eclampsia), gestational diabetes mellitus, preterm birth, and low birth weight. Generalized additive mixed models were used to characterize longitudinal changes in systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP). Group-based trajectory modeling was applied to identify distinct BP trajectory groups. Multinomial logistic regression with marginal standardization estimated adjusted risk ratio (aRR).Results

During a mean follow-up of 9.2 years, SBP showed a nonlinear increase, with an average slope of 1.13 mmHg/year (95% CI, 0.93-1.33) during the first 6.4 years, followed by slower increases of 0.73 and 0.59 mmHg/year during 6.4-10 and 10-15 years, respectively. DBP showed a near-linear increasing pattern, whereas MAP increased linearly. Three trajectory groups were identified for each BP component. APOs were associated with higher risks of high-level SBP (aRR = 1.64; 95% CI: 1.19-2.66), DBP (aRR = 1.61, 95% CI: 1.24-1.87), and MAP (aRR = 2.11, 95% CI: 1.16-3.64) trajectories compared with membership in the low-level BP trajectory groups. Associations varied across APOs subtypes. GDM and PTB were associated with higher risk of membership in the high-level SBP, DBP, and MAP trajectory groups compared with the corresponding low-level trajectory groups.Conclusion

Different BP components exhibit distinct longitudinal patterns after delivery, APOs are associated with heterogeneous and unfavorable long-term postpartum BP trajectories.

Related

  1. Trajectories of perinatal depression, anxiety, perceived stress, sleep quality, and psychological flexibility from pregnancy to six months postpartum and their relationship with the number of abortions and deliveries
    Yan Gao, Jingwen Sun, Lei Yang +3
    Frontiers in PsychiatryPeer-reviewedCC BY 4.0Full textEpidemiology & public healthCrossref
  2. Acute triggers and long-term postpartum outcomes of diabetic ketoacidosis in pregnancy: a 7-case retrospective series.
    Ya-Li Yang, Qiao-Fang Yang, Xu-Fei Fan
    BMC pregnancy and childbirthPeer-reviewedCC BY-NC-NDFull textObstetrics, gynaecology & paediatricsEurope PMCDOAJ
  3. Association of dynapenia with adverse physical function trajectories in community-dwelling adults: a CHARLS cohort study
    Yanru Li, Yunkang Wang, Yanlan Li +2
    BMC Public HealthPeer-reviewedCC BY-NC-ND 4.0PhysiologyCrossref
  4. Association of synergistic trajectories between early mobilization potential and actual implementation with clinical outcomes among ICU patients with pneumonia: a multivariate latent class mixed model analysis
    Journal of thoracic diseasePeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
  5. Association of adverse pregnancy outcomes with coronary microvascular dysfunction: a systematic review and meta-analysis
    Syeda Beenish Bareeqa, Syed Hasham Humayun, Sourbha Satish Dani
    American journal of preventive cardiologyPeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{liu2026association,
  title = {{Association between adverse pregnancy outcomes and long-term postpartum blood pressure trajectories: a community-based cohort study.}},
  author = {Nan-Di Liu and Li-Hua Chen and Dan-Tong Wang and Yi-Fan Wang and Mei-Chen Yang and Chang-Hao Zu and Hong-Hong He and Hong-Min Liu and Li-Ming Lin and Li-Xia Sun and Xiao-Jia Xu and Hai-Yan Zhao},
  journal = {Frontiers in public health},
  year = {2026},
  month = oct,
  doi = {10.3389/fpubh.2026.1924151},
  url = {https://europepmc.org/article/MED/42908599},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Association between adverse pregnancy outcomes and long-term postpartum blood pressure trajectories: a community-based cohort study.
AU  - Nan-Di Liu
AU  - Li-Hua Chen
AU  - Dan-Tong Wang
AU  - Yi-Fan Wang
AU  - Mei-Chen Yang
AU  - Chang-Hao Zu
AU  - Hong-Hong He
AU  - Hong-Min Liu
AU  - Li-Ming Lin
AU  - Li-Xia Sun
AU  - Xiao-Jia Xu
AU  - Hai-Yan Zhao
PY  - 2026
DA  - 2026/10/07
JO  - Frontiers in public health
DO  - 10.3389/fpubh.2026.1924151
UR  - https://europepmc.org/article/MED/42908599
AB  - Background  Adverse pregnancy outcomes (APOs) increase the future risk of hypertension, but their impact on long-term postpartum blood pressure (BP) trajectories remains unclear. We aimed to characterize these trajectories and compare trajectory membership between women with and without APOs.Methods  This community-based cohort study included 1,346 women with documented deliveries (2004-2020) from the Kailuan Study who underwent at least three postpartum health examinations between 2006 and 2022. APOs included hypertensive disorders of pregnancy (gestational hypertension and preeclampsia/eclampsia), gestational diabetes mellitus, preterm birth, and low birth weight. Generalized additive mixed models were used to characterize longitudinal changes in systolic BP (SBP), diastolic BP (DBP), and mean arterial pressure (MAP). Group-based trajectory modeling was applied to identify distinct BP trajectory groups. Multinomial logistic regression with marginal standardization estimated adjusted risk ratio (aRR).Results  During a mean follow-up of 9.2 years, SBP showed a nonlinear increase, with an average slope of 1.13 mmHg/year (95% CI, 0.93-1.33) during the first 6.4 years, followed by slower increases of 0.73 and 0.59 mmHg/year during 6.4-10 and 10-15 years, respectively. DBP showed a near-linear increasing pattern, whereas MAP increased linearly. Three trajectory groups were identified for each BP component. APOs were associated with higher risks of high-level SBP (aRR = 1.64; 95% CI: 1.19-2.66), DBP (aRR = 1.61, 95% CI: 1.24-1.87), and MAP (aRR = 2.11, 95% CI: 1.16-3.64) trajectories compared with membership in the low-level BP trajectory groups. Associations varied across APOs subtypes. GDM and PTB were associated with higher risk of membership in the high-level SBP, DBP, and MAP trajectory groups compared with the corresponding low-level trajectory groups.Conclusion  Different BP components exhibit distinct longitudinal patterns after delivery, APOs are associated with heterogeneous and unfavorable long-term postpartum BP trajectories.
SN  - 2296-2565
ER  -