Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 20 min ago
Peer-reviewedCC BYCurrent oncology (Toronto, Ont.)

Evaluating the Prognostic Significance of the H-Index and Systemic Inflammatory Parameters in IDH-Wildtype Glioblastoma Survival.

  • Havva Yeşil1
  • Bekir Demirel2
  • Ercan Gumusburun1
  1. 1Department of Medical Oncology, Faculty of Medicine, Gaziantep University, 27310 Gaziantep, Türkiye.
  2. 2Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27310 Gaziantep, Türkiye.
Read full textPDFDOICite

Abstract

Background: IDH-wildtype Glioblastoma is characterized by an aggressive clinical course. This study aimed to evaluate the prognostic value of the H-index, the hemoglobin-albumin-lymphocyte-platelet (HALP) score and the aggregate index of systemic inflammation (AISI). Methods: We retrospectively analyzed 136 patients who underwent frontline chemoradiotherapy. Results: Optimal cut-offs were 20.94 for HALP, 2.29 for H-index, and 989.64 for AISI. A high H-index was associated with shorter overall survival (OS) in univariate analysis (p = 0.007) and showed the highest time-dependent AUC for OS among the three indices. In multivariable Cox models, comorbidities (p = 0.043), subtotal resection (p < 0.001), corticosteroid use (p = 0.040), and a low HALP score (p = 0.012) were associated with poor OS, whereas the associations for a high H-index (p = 0.084) and a high AISI (p = 0.036) did not meet the Bonferroni-adjusted significance threshold. In a sensitivity analysis restricted to patients not receiving corticosteroids (n = 80), H-index-based stratification remained associated with OS (median 14.4 vs. 24.9 months, log-rank p = 0.025), whereas the association for AISI was not retained. Conclusions: The H-index, evaluated here for the first time, and the HALP score may provide complementary prognostic information. Given the retrospective single-center design, the potential influence of corticosteroids, and the data-driven cut-offs, these findings should be regarded as exploratory and require external validation before clinical application.

Related

  1. The Correlation of PD-L1 Expression with Tumor Budding: Evaluating the Significance of Scoring Differences in Non-Small Cell Lung Cancer
    Funda Canaz, Furkan Albayrak, Güntülü Ak +5
    BiomedicinesPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  2. Prognostic significance and clinicopathologic prediction of tumor deposits in non-metastatic colon mucinous adenocarcinoma
    Yidan Qu, Jizheng Gong, Wenwei Lan +2
    Scientific ReportsPeer-reviewedCC BY-NC-ND 4.0Full textOncologyCrossref
  3. Prognostic Significance of Serum Sodium in Patients With Acute Pulmonary Embolism
    Patchara Kochaiyapatana, Sukrisd Koowattanatianchai, Jayanton Patumanond +2
    Journal of Clinical Medicine ResearchPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. Prognostic Significance of CD47 and DHX9 in Metastatic Rectal Cancer
    Sendag Yaslikaya, Suheda Atas Ipek, Tugba Toyran +2
    Medical sciences (Basel, Switzerland)Peer-reviewedCC BYFull textGeneral medicineEurope PMC
  5. Prognostic significance of CCT5 in breast cancer and its regulatory mechanisms in promoting tumorigenesis
    Jianwen Wang, Yuming Chen, Qiang Zhu +7
    Scientific ReportsPeer-reviewedCC BY-NC-ND 4.0Full textOncologyCrossref

Cite

BibTeXRIS
BibTeX
@article{yesil2026evaluating,
  title = {{Evaluating the Prognostic Significance of the H-Index and Systemic Inflammatory Parameters in IDH-Wildtype Glioblastoma Survival.}},
  author = {Havva Yeşil and Bekir Demirel and Ercan Gumusburun},
  journal = {Current oncology (Toronto, Ont.)},
  year = {2026},
  month = oct,
  doi = {10.3390/curroncol33100604},
  url = {https://europepmc.org/article/MED/42930171},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Evaluating the Prognostic Significance of the H-Index and Systemic Inflammatory Parameters in IDH-Wildtype Glioblastoma Survival.
AU  - Havva Yeşil
AU  - Bekir Demirel
AU  - Ercan Gumusburun
PY  - 2026
DA  - 2026/10/08
JO  - Current oncology (Toronto, Ont.)
DO  - 10.3390/curroncol33100604
UR  - https://europepmc.org/article/MED/42930171
AB  - Background: IDH-wildtype Glioblastoma is characterized by an aggressive clinical course. This study aimed to evaluate the prognostic value of the H-index, the hemoglobin-albumin-lymphocyte-platelet (HALP) score and the aggregate index of systemic inflammation (AISI). Methods: We retrospectively analyzed 136 patients who underwent frontline chemoradiotherapy. Results: Optimal cut-offs were 20.94 for HALP, 2.29 for H-index, and 989.64 for AISI. A high H-index was associated with shorter overall survival (OS) in univariate analysis (p = 0.007) and showed the highest time-dependent AUC for OS among the three indices. In multivariable Cox models, comorbidities (p = 0.043), subtotal resection (p < 0.001), corticosteroid use (p = 0.040), and a low HALP score (p = 0.012) were associated with poor OS, whereas the associations for a high H-index (p = 0.084) and a high AISI (p = 0.036) did not meet the Bonferroni-adjusted significance threshold. In a sensitivity analysis restricted to patients not receiving corticosteroids (n = 80), H-index-based stratification remained associated with OS (median 14.4 vs. 24.9 months, log-rank p = 0.025), whereas the association for AISI was not retained. Conclusions: The H-index, evaluated here for the first time, and the HALP score may provide complementary prognostic information. Given the retrospective single-center design, the potential influence of corticosteroids, and the data-driven cut-offs, these findings should be regarded as exploratory and require external validation before clinical application.
SN  - 1198-0052
SN  - 1718-7729
ER  -