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Peer-reviewedCC BY 4.0Animal Models and Experimental Medicine

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

  • Liya Hou1,2,3,4
  • Xue Liu5,6
  • Wangxing Hu1,2,3,4
  • Xianbao Liu1,2,3,4
  • Wei Zhu1,2,3,4
6 affiliations
  1. 1Department of Cardiology The Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou China
  2. 2State Key Laboratory of Transvascular Implantation Devices Hangzhou China
  3. 3Heart Regeneration and Repair Key Laboratory of Zhejiang Province Hangzhou China
  4. 4Transvascular Implantation Devices Research Institute Hangzhou China
  5. 5The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou China
  6. 6The First Clinical Medical College of Zhejiang Chinese Medical University Hangzhou China
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Abstract

The global public health burden of aortic valve disease (AVD) is growing due to its high mortality rate and lack of suitable pharmaceutical therapies in clinical practice, a challenge that is largely attributable to our poor understanding of its complicated underlying mechanisms. A better understanding of the pathological processes underlying AVD is urgently needed to identify novel therapeutic options. Appropriate animal models are emerging as vital tools for basic and translational research, and the development of new models and the important information they have provided has significantly aided our research. However, different animal models have unique limitations in their ability to mimic human AVD pathology. In this review, we summarize the available AVD animal models and provide a detailed description of the major principles underlying each animal model, including methodology, pathological features, and potential use and application in AVD research. Both the advantages and disadvantages of specific models are also carefully highlighted; thus this comprehensive review provides a valuable animal model reference for both basic and preclinical researchers.

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Cite

BibTeXRIS
BibTeX
@article{hou2026aortic,
  title = {{Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms}},
  author = {Liya Hou and Xue Liu and Wangxing Hu and Xianbao Liu and Wei Zhu},
  journal = {Animal Models and Experimental Medicine},
  year = {2026},
  month = sep,
  doi = {10.1002/ame2.70294},
  url = {https://doi.org/10.1002/ame2.70294},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms
AU  - Liya Hou
AU  - Xue Liu
AU  - Wangxing Hu
AU  - Xianbao Liu
AU  - Wei Zhu
PY  - 2026
DA  - 2026/09/27
JO  - Animal Models and Experimental Medicine
DO  - 10.1002/ame2.70294
UR  - https://doi.org/10.1002/ame2.70294
AB  - The global public health burden of aortic valve disease (AVD) is growing due to its high mortality rate and lack of suitable pharmaceutical therapies in clinical practice, a challenge that is largely attributable to our poor understanding of its complicated underlying mechanisms. A better understanding of the pathological processes underlying AVD is urgently needed to identify novel therapeutic options. Appropriate animal models are emerging as vital tools for basic and translational research, and the development of new models and the important information they have provided has significantly aided our research. However, different animal models have unique limitations in their ability to mimic human AVD pathology. In this review, we summarize the available AVD animal models and provide a detailed description of the major principles underlying each animal model, including methodology, pathological features, and potential use and application in AVD research. Both the advantages and disadvantages of specific models are also carefully highlighted; thus this comprehensive review provides a valuable animal model reference for both basic and preclinical researchers.
SN  - 2096-5451
SN  - 2576-2095
ER  -