Quality of life after open descending thoracic and thoracoabdominal aortic repair: A prospective cohort study.
- 1Department of Cardiothoracic Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
- 2Department of Intensive Care, Radboud University Medical Center, Nijmegen, The Netherlands.
Abstract
Objective
To longitudinally evaluate health-related quality of life (HRQoL) following open descending thoracic or thoracoabdominal aortic aneurysm repair, with validated patient-reported outcome measures.Methods
In this prospective, single-center cohort study, patients who underwent open descending thoracic or thoracoabdominal aortic aneurysm repair between 2016 and 2023 were included. HRQoL was assessed preoperatively and at 3, 12, and 24 months postoperatively with the Short Form-12 physical component summary (PCS) and mental component summary (MCS) scores. Secondary quality-of-life scores were included as well. Additionally, complete-case analysis and the impact of baseline variables were assessed. Longitudinal changes were analyzed with linear mixed-effects models.Results
In total, 128 patients were included. PCS scores (95% CIs) decreased from 46.0 (44.1-48.0) preoperatively to 39.7 (37.6-41.7) at 3 months, with partial recovery to 42.2 (40.2-44.2) at 1 year and 41.0 (38.1-43.9) at 2 years (overall P < .001). MCS scores (95% CIs) decreased initially from 47.4 (44.9-49.8) to 44.3 (41.8-46.9) (3 months), with recovery to 49.2 (46.7-51.7) (1 year) and 48.4 (44.6-52.2) (2 years) (overall P = .01). Complete-case analysis showed comparable trajectories. Anxiety decreased and cognitive complaints increased but remained within normal ranges. No baseline variables were independently associated with PCS or MCS score trajectories.Conclusions
Open descending thoracic and thoracoabdominal aortic aneurysm repair is associated with a sustained reduction in physical HRQoL, while mental HRQoL recovers. These findings underscore the multidimensional nature of recovery and the importance of integrating patient-reported outcomes into perioperative care.
Related
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- Aortopulmonary Fistula Complicating a Ruptured Infected Proximal Descending Thoracic Aortic Pseudoaneurysm.
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- A neonatal extra-anatomical bypass for a “corkscrew” descending aorta associated with interrupted right aortic arch
BibTeX
@article{sambeeck2026quality,
title = {{Quality of life after open descending thoracic and thoracoabdominal aortic repair: A prospective cohort study.}},
author = {Pim S van Sambeeck and Nesar A Hasami and Stefan R van Dinter and Foeke J H Nauta and Nabil Saouti and Michel W A Verkroost and Marieke Zegers and Guillaume S C Geuzebroek and Mark van den Boogaard and Robin H Heijmen},
journal = {JTCVS open},
year = {2026},
month = aug,
doi = {10.1016/j.xjon.2026.102081},
url = {https://europepmc.org/article/MED/42948473},
note = {CC BY},
}
RIS
TY - JOUR
TI - Quality of life after open descending thoracic and thoracoabdominal aortic repair: A prospective cohort study.
AU - Pim S van Sambeeck
AU - Nesar A Hasami
AU - Stefan R van Dinter
AU - Foeke J H Nauta
AU - Nabil Saouti
AU - Michel W A Verkroost
AU - Marieke Zegers
AU - Guillaume S C Geuzebroek
AU - Mark van den Boogaard
AU - Robin H Heijmen
PY - 2026
DA - 2026/08/25
JO - JTCVS open
DO - 10.1016/j.xjon.2026.102081
UR - https://europepmc.org/article/MED/42948473
AB - Objective To longitudinally evaluate health-related quality of life (HRQoL) following open descending thoracic or thoracoabdominal aortic aneurysm repair, with validated patient-reported outcome measures.Methods In this prospective, single-center cohort study, patients who underwent open descending thoracic or thoracoabdominal aortic aneurysm repair between 2016 and 2023 were included. HRQoL was assessed preoperatively and at 3, 12, and 24 months postoperatively with the Short Form-12 physical component summary (PCS) and mental component summary (MCS) scores. Secondary quality-of-life scores were included as well. Additionally, complete-case analysis and the impact of baseline variables were assessed. Longitudinal changes were analyzed with linear mixed-effects models.Results In total, 128 patients were included. PCS scores (95% CIs) decreased from 46.0 (44.1-48.0) preoperatively to 39.7 (37.6-41.7) at 3 months, with partial recovery to 42.2 (40.2-44.2) at 1 year and 41.0 (38.1-43.9) at 2 years (overall P < .001). MCS scores (95% CIs) decreased initially from 47.4 (44.9-49.8) to 44.3 (41.8-46.9) (3 months), with recovery to 49.2 (46.7-51.7) (1 year) and 48.4 (44.6-52.2) (2 years) (overall P = .01). Complete-case analysis showed comparable trajectories. Anxiety decreased and cognitive complaints increased but remained within normal ranges. No baseline variables were independently associated with PCS or MCS score trajectories.Conclusions Open descending thoracic and thoracoabdominal aortic aneurysm repair is associated with a sustained reduction in physical HRQoL, while mental HRQoL recovers. These findings underscore the multidimensional nature of recovery and the importance of integrating patient-reported outcomes into perioperative care.
SN - 2666-2736
ER -