CONSTANCES, the French nationwide population cohort: major accomplishments
Abstract
The CONSTANCES cohort is an epidemiological research infrastructure accessible to the international epidemiologic research community (doi.org/ https://doi.org/10.13143/inserm_constances ). CONSTANCES also provides public health authorities with data regarding prevalence of numerous health conditions and determinants among the French population. CONSTANCES comprises a representative sample of about 220,000 French adults aged 18-69 at enrolment (7.6% participation rate). Follow-up begins at enrolment and is intended to last for the lifetimes of study participants. At inclusion, the selected subjects completed questionnaires and underwent a comprehensive health examination. A biobank was established. The follow-up includes a yearly self-administered questionnaire, and a health examination every four years. Social and health data are collected continually from French national administrative databases. The data collected cover a wide spectrum of somatic and mental health disorders, social and demographic characteristics, socioeconomic status, life events, behaviors, environmental and occupational factors. In order to estimate prevalences that are unbiased by non-participation, weighting methods based on data from national administrative databases were developed. The CONSTANCES research infrastructure is open to legitimate researchers from any country, on any topic for which a sound research project is proposed, and for which certain ethical conditions are met. Up to 2025, over 200 projects have been conducted and more than 250 papers have been published; the numbers are expected to grow as the participants age. Highlighting the broad scope of CONSTANCES data collection, already published papers pertain to many health research fields, such as chronic diseases, aging, women's health, environmental and occupational risks or research methods.
Related
- The role and evolution of partial splenic embolization over three decades: A multicentric retrospective single cohort study of 90 patients from French nationwide experience
- FODMAP Consumption by Adults from the French Population-Based NutriNet-Santé Cohort
- Healthcare trajectories diverge years before Huntington disease is recorded in claims: a nationwide French matched cohort study
- Opioid agonist treatment and risk of mortality in French primary care: a nationwide, retrospective cohort study
- Glucocorticoid in giant cell arteritis: real-world treatment patterns over time and associated burden in a nationwide hospital-based study within the French health insurance database
BibTeX
@article{zins2026constances,
title = {{CONSTANCES, the French nationwide population cohort: major accomplishments}},
author = {Marie Zins and Marcel Goldberg and Sofiane Kab and Jack Siemiatycki and Antoine Duclos and Guillaume Airagnes and Marylène Baylet and Sophie Bonnaud and Hanifa Bouziri and Claudette Carole and Mireille Coeuret-Pellicer and Betül Demir and Naby Dia and Ndeye Marie Diouf and Rita El Haddad and Fabien Gilbert and Julie Gourmelen and Emeline Heyndrickx-Gallin and Eya Jlidi and Auriol Koutangni and Sophie Launay and Stéphane Le Got and Annette Leclerc and Sylvie Lemonnier and Émeline Lequy-Flahault and Nathalie Lopes and Tassadit Madaoui and Ghiles Meddour and Anna Ozguler and Ariane Quesnot and Adeline Renuy and Céline Ribet and Ines Saidi and Emmanuel Wiernik and Constance Yvon},
journal = {European Journal of Epidemiology},
year = {2026},
month = oct,
doi = {10.1007/s10654-026-01463-6},
url = {https://hal.science/hal-05839147v1},
note = {CC BY},
}
RIS
TY - JOUR
TI - CONSTANCES, the French nationwide population cohort: major accomplishments
AU - Marie Zins
AU - Marcel Goldberg
AU - Sofiane Kab
AU - Jack Siemiatycki
AU - Antoine Duclos
AU - Guillaume Airagnes
AU - Marylène Baylet
AU - Sophie Bonnaud
AU - Hanifa Bouziri
AU - Claudette Carole
AU - Mireille Coeuret-Pellicer
AU - Betül Demir
AU - Naby Dia
AU - Ndeye Marie Diouf
AU - Rita El Haddad
AU - Fabien Gilbert
AU - Julie Gourmelen
AU - Emeline Heyndrickx-Gallin
AU - Eya Jlidi
AU - Auriol Koutangni
AU - Sophie Launay
AU - Stéphane Le Got
AU - Annette Leclerc
AU - Sylvie Lemonnier
AU - Émeline Lequy-Flahault
AU - Nathalie Lopes
AU - Tassadit Madaoui
AU - Ghiles Meddour
AU - Anna Ozguler
AU - Ariane Quesnot
AU - Adeline Renuy
AU - Céline Ribet
AU - Ines Saidi
AU - Emmanuel Wiernik
AU - Constance Yvon
PY - 2026
DA - 2026/10/12
JO - European Journal of Epidemiology
DO - 10.1007/s10654-026-01463-6
UR - https://hal.science/hal-05839147v1
AB - The CONSTANCES cohort is an epidemiological research infrastructure accessible to the international epidemiologic research community (doi.org/ https://doi.org/10.13143/inserm_constances ). CONSTANCES also provides public health authorities with data regarding prevalence of numerous health conditions and determinants among the French population. CONSTANCES comprises a representative sample of about 220,000 French adults aged 18-69 at enrolment (7.6% participation rate). Follow-up begins at enrolment and is intended to last for the lifetimes of study participants. At inclusion, the selected subjects completed questionnaires and underwent a comprehensive health examination. A biobank was established. The follow-up includes a yearly self-administered questionnaire, and a health examination every four years. Social and health data are collected continually from French national administrative databases. The data collected cover a wide spectrum of somatic and mental health disorders, social and demographic characteristics, socioeconomic status, life events, behaviors, environmental and occupational factors. In order to estimate prevalences that are unbiased by non-participation, weighting methods based on data from national administrative databases were developed. The CONSTANCES research infrastructure is open to legitimate researchers from any country, on any topic for which a sound research project is proposed, and for which certain ethical conditions are met. Up to 2025, over 200 projects have been conducted and more than 250 papers have been published; the numbers are expected to grow as the participants age. Highlighting the broad scope of CONSTANCES data collection, already published papers pertain to many health research fields, such as chronic diseases, aging, women's health, environmental and occupational risks or research methods.
SN - 0393-2990
SN - 1573-7284
ER -