Reference frame for Adult Brainstem gliomas
Abstract
Brainstem gliomas (BSG) are rare in adults (less than 2% of all gliomas) and generally have a better prognosis than pediatric BSG, although outcomes remain heterogeneous. Many other central nervous system (CNS) tumors, as well as nontumoral lesions, have been described as differential diagnoses and should be kept in mind. Each case should be examined by neurosurgeons from specialized centers to determine the most appropriate surgical approach among stereotactic biopsy, open biopsy, and tumor resection. Surgery may sometimes be performed in expert centers. The main objectives of tumor tissue sampling are to perform histomolecular analyses to confirm the diagnosis, determine the tumor subtype, and identify potential prognostic and theranostic biomarkers. Tissue preservation is essential to ensure that sufficient tumor material is available for further molecular analyses for diagnostic or therapeutic purposes. Results of ctDNA detection in CSF should only be considered if they are positive. The management of BSGs in adults remains non-standardized, largely because most glioma trials exclude tumors located in this specific site. To date, no prospective trials have established clear treatment guidelines, and most of the available data come from retrospective studies or extrapolation of data from other locations. Radiotherapy (RT) is one of the main treatment options for BSGs in adults. The role of chemotherapy remains unclear due to limited data in literature and is currently being studied. Several molecular targets with therapeutic potential, including recurrent genetic mutations and fusion transcripts, have been identified in adult BSGs.
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BibTeX
@article{laigledonadey2026reference,
title = {{Reference frame for Adult Brainstem gliomas}},
author = {Florence Laigle-Donadey and Emmanuel Mesny and Franck Bielle and Aurélie Kas and Lucia Nichelli and Carole Ramirez and Laura Rozenblum and Olivier Langlois and Guido Ahle and Luc Bauchet and Loic Feuvret and Maxime Fontanilles and Julien Savatovsky and Jean-Marc Constans and Nadya Pyatigorskaya and Mehdi Touat and Julian Jacob and Emmanuel Jouglar and Luc Ollivier and Elsa Magro and Matthieu Boone and Apolline Monfilliette and Enora Vauleon and Philippe Menei and Ahmed Idbaih and Jean-Sébastien Guillamo and Elodie Vauleon and François Ducray and Caroline Dehais and Sylvie Grand and Bertrand Mathon and François Ducray and Guido Ahle and Fabien Almeirac and Luc Bauchet and Franck Bielle and Alice Bonneville-Levard and Véronique Bourg and Charlotte Bronnimann and Marie-Dominique Cantal-Dupart and Hélène Castel Gandolfo and Olivier Chinot and Stefania Cuzzubbo and Amélie Darlix and Caroline Dehais and Frédéric Dhermain and François Ducray and Sarah Dumont and Walid Farah and Loïc Feuvret and Dominique Figarella Branger and Maxime Fontanilles and Jean Sébastien Guillamo and Khê Hoang Xuan and Jérôme Honnorat and Catherine Horodyckid and Andreas Hottinger and Ahmed Idbaih and Armelle Lacroux and Florence Laigle Donadey},
journal = {The Oncologist},
year = {2026},
month = oct,
doi = {10.1093/oncolo/oyag403},
url = {https://u-picardie.hal.science/hal-05796604v1},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Reference frame for Adult Brainstem gliomas
AU - Florence Laigle-Donadey
AU - Emmanuel Mesny
AU - Franck Bielle
AU - Aurélie Kas
AU - Lucia Nichelli
AU - Carole Ramirez
AU - Laura Rozenblum
AU - Olivier Langlois
AU - Guido Ahle
AU - Luc Bauchet
AU - Loic Feuvret
AU - Maxime Fontanilles
AU - Julien Savatovsky
AU - Jean-Marc Constans
AU - Nadya Pyatigorskaya
AU - Mehdi Touat
AU - Julian Jacob
AU - Emmanuel Jouglar
AU - Luc Ollivier
AU - Elsa Magro
AU - Matthieu Boone
AU - Apolline Monfilliette
AU - Enora Vauleon
AU - Philippe Menei
AU - Ahmed Idbaih
AU - Jean-Sébastien Guillamo
AU - Elodie Vauleon
AU - François Ducray
AU - Caroline Dehais
AU - Sylvie Grand
AU - Bertrand Mathon
AU - François Ducray
AU - Guido Ahle
AU - Fabien Almeirac
AU - Luc Bauchet
AU - Franck Bielle
AU - Alice Bonneville-Levard
AU - Véronique Bourg
AU - Charlotte Bronnimann
AU - Marie-Dominique Cantal-Dupart
AU - Hélène Castel Gandolfo
AU - Olivier Chinot
AU - Stefania Cuzzubbo
AU - Amélie Darlix
AU - Caroline Dehais
AU - Frédéric Dhermain
AU - François Ducray
AU - Sarah Dumont
AU - Walid Farah
AU - Loïc Feuvret
AU - Dominique Figarella Branger
AU - Maxime Fontanilles
AU - Jean Sébastien Guillamo
AU - Khê Hoang Xuan
AU - Jérôme Honnorat
AU - Catherine Horodyckid
AU - Andreas Hottinger
AU - Ahmed Idbaih
AU - Armelle Lacroux
AU - Florence Laigle Donadey
PY - 2026
DA - 2026/10/15
JO - The Oncologist
DO - 10.1093/oncolo/oyag403
UR - https://u-picardie.hal.science/hal-05796604v1
AB - Brainstem gliomas (BSG) are rare in adults (less than 2% of all gliomas) and generally have a better prognosis than pediatric BSG, although outcomes remain heterogeneous. Many other central nervous system (CNS) tumors, as well as nontumoral lesions, have been described as differential diagnoses and should be kept in mind. Each case should be examined by neurosurgeons from specialized centers to determine the most appropriate surgical approach among stereotactic biopsy, open biopsy, and tumor resection. Surgery may sometimes be performed in expert centers. The main objectives of tumor tissue sampling are to perform histomolecular analyses to confirm the diagnosis, determine the tumor subtype, and identify potential prognostic and theranostic biomarkers. Tissue preservation is essential to ensure that sufficient tumor material is available for further molecular analyses for diagnostic or therapeutic purposes. Results of ctDNA detection in CSF should only be considered if they are positive. The management of BSGs in adults remains non-standardized, largely because most glioma trials exclude tumors located in this specific site. To date, no prospective trials have established clear treatment guidelines, and most of the available data come from retrospective studies or extrapolation of data from other locations. Radiotherapy (RT) is one of the main treatment options for BSGs in adults. The role of chemotherapy remains unclear due to limited data in literature and is currently being studied. Several molecular targets with therapeutic potential, including recurrent genetic mutations and fusion transcripts, have been identified in adult BSGs.
SN - 1083-7159
SN - 1549-490X
ER -