The ACUte effects of SITting time on physiological and psychological function in older adults (ACUSIT): An observational cohort study
- 1University of Birmingham
Abstract
IntroductionThere is accumulating evidence supporting the longer-term detrimental health effects of prolonged bouts of sedentary behaviour (sitting). However, there are less data relating to older adults and in particular, the acute dose-response effects of uninterrupted sitting are lacking. This study aimed to identify key physiological and psychological outcomes influenced by acute periods of inactivity.
MethodsThe study utilised a randomised cross-over design. Participants randomly completed sitting times of 1, 2 and 4 hours on separate days at the same time of day, and were permitted to watch television, knit or read but not to sleep. The sitting times corresponded to a brief control period of sitting (1 hour (h)), moderately sedentary (2-4 h per day) and sedentary (>4 h per day). The primary outcome measure was lower limb power output using the Nottingham Power Rig (Watts (W)/kg). Secondary outcomes included a range of physiological and psychological measures. Assessments were made before and after each period of sitting time in a temperature-controlled room. Differences between the pre and post measurements across each session were analysed using repeated measures ANOVA with post-hoc comparisons to determine between condition differences.
ResultsLower limb power output did not change significantly (p = 0.67) following the 1 h (pre: 1.44 {+/-} 0.6, post: 1.461 {+/-} 0.6 W/kg), 2 h (pre 1.42 {+/-} 0.7, post: 1.44 {+/-} 0.6 W/kg) and 4 h (pre: 1.47 {+/-} 0.7, post: 1.44 {+/-} 0.6 W/kg) sitting times. A significant increase in mean systolic and diastolic blood pressure was recorded following the 2h (systolic pre: 137 {+/-} 13, post: 141 {+/-} 6 mmHg; p<0.001; diastolic pre: 74 {+/-} 10, post 76 {+/-} 10mmHg; p<0.001) and 4 h sitting times (systolic pre 137 {+/-} 14, post 147 {+/-} 15 mmHg; p<0.001; diastolic pre 73 {+/-} 10, post 79 {+/-} 10 mmHg; p<0.001). Mean arterial pressure also significantly increased after the 2 h (pre: 95 {+/-} 10, post: 97 {+/-} 11 mmHg; p<0.001) and 4 h (pre: 95 {+/-} 10, post: 102 {+/-} 10 mmHg; p<0.001) periods of sitting. Timed Up & Go performance declined after all sessions of sitting (p=0.01) whereas Digit Symbol Substitution (DSS) scores (p=0.001) and % DSS correct scores (p<0.001) improved. Vitality declined across all sessions, but this was significantly worse after 4 h. Psychological outcome measure subscales (Profile of Mood State; POMS) related to vigour and friendliness showed significant adverse changes across all sessions, although vigour was worst after 4 h sitting. Further, fatigue changes were greater and negative after 2 and 4 h sitting compared to 1 h, and post-sitting values were highest after 4 h. Data obtained for inflammatory markers was inconclusive, due mainly to concentrations being out of range of measurement. In a small subset of participants (n=13), significant increases in bladder volume comparing post with pre-sitting time were found across all 3 sitting periods (p<0.05), however there were no significant differences between sessions.
ConclusionsThese data show that sitting for 2 h or more may have potentially deleterious effects on cardiovascular biomarkers including blood pressure, as well as increasing the risk of falling. Vitality, vigour and fatigue, subscales of mood may also be adversely affected in older adults. These effects appear to increase with continuous sitting time.
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BibTeX
@misc{agyapongbadu2026acute,
title = {{The ACUte effects of SITting time on physiological and psychological function in older adults (ACUSIT): An observational cohort study}},
author = {S. Agyapong-Badu and C. Greig and E. Bostock and K. C. McGee and J. Black and E. Poses-Ferrer and T. Jackson and C. Welch and S. F. Chastin and A. C. Whittaker and D. A. Skelton},
howpublished = {medRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.08.26362486},
url = {https://www.medrxiv.org/content/10.64898/2026.09.08.26362486v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - The ACUte effects of SITting time on physiological and psychological function in older adults (ACUSIT): An observational cohort study
AU - S. Agyapong-Badu
AU - C. Greig
AU - E. Bostock
AU - K. C. McGee
AU - J. Black
AU - E. Poses-Ferrer
AU - T. Jackson
AU - C. Welch
AU - S. F. Chastin
AU - A. C. Whittaker
AU - D. A. Skelton
PY - 2026
DA - 2026/09/08
PB - medRxiv
DO - 10.64898/2026.09.08.26362486
UR - https://www.medrxiv.org/content/10.64898/2026.09.08.26362486v1
AB - IntroductionThere is accumulating evidence supporting the longer-term detrimental health effects of prolonged bouts of sedentary behaviour (sitting). However, there are less data relating to older adults and in particular, the acute dose-response effects of uninterrupted sitting are lacking. This study aimed to identify key physiological and psychological outcomes influenced by acute periods of inactivity. MethodsThe study utilised a randomised cross-over design. Participants randomly completed sitting times of 1, 2 and 4 hours on separate days at the same time of day, and were permitted to watch television, knit or read but not to sleep. The sitting times corresponded to a brief control period of sitting (1 hour (h)), moderately sedentary (2-4 h per day) and sedentary (>4 h per day). The primary outcome measure was lower limb power output using the Nottingham Power Rig (Watts (W)/kg). Secondary outcomes included a range of physiological and psychological measures. Assessments were made before and after each period of sitting time in a temperature-controlled room. Differences between the pre and post measurements across each session were analysed using repeated measures ANOVA with post-hoc comparisons to determine between condition differences. ResultsLower limb power output did not change significantly (p = 0.67) following the 1 h (pre: 1.44 {+/-} 0.6, post: 1.461 {+/-} 0.6 W/kg), 2 h (pre 1.42 {+/-} 0.7, post: 1.44 {+/-} 0.6 W/kg) and 4 h (pre: 1.47 {+/-} 0.7, post: 1.44 {+/-} 0.6 W/kg) sitting times. A significant increase in mean systolic and diastolic blood pressure was recorded following the 2h (systolic pre: 137 {+/-} 13, post: 141 {+/-} 6 mmHg; p<0.001; diastolic pre: 74 {+/-} 10, post 76 {+/-} 10mmHg; p<0.001) and 4 h sitting times (systolic pre 137 {+/-} 14, post 147 {+/-} 15 mmHg; p<0.001; diastolic pre 73 {+/-} 10, post 79 {+/-} 10 mmHg; p<0.001). Mean arterial pressure also significantly increased after the 2 h (pre: 95 {+/-} 10, post: 97 {+/-} 11 mmHg; p<0.001) and 4 h (pre: 95 {+/-} 10, post: 102 {+/-} 10 mmHg; p<0.001) periods of sitting. Timed Up & Go performance declined after all sessions of sitting (p=0.01) whereas Digit Symbol Substitution (DSS) scores (p=0.001) and % DSS correct scores (p<0.001) improved. Vitality declined across all sessions, but this was significantly worse after 4 h. Psychological outcome measure subscales (Profile of Mood State; POMS) related to vigour and friendliness showed significant adverse changes across all sessions, although vigour was worst after 4 h sitting. Further, fatigue changes were greater and negative after 2 and 4 h sitting compared to 1 h, and post-sitting values were highest after 4 h. Data obtained for inflammatory markers was inconclusive, due mainly to concentrations being out of range of measurement. In a small subset of participants (n=13), significant increases in bladder volume comparing post with pre-sitting time were found across all 3 sitting periods (p<0.05), however there were no significant differences between sessions. ConclusionsThese data show that sitting for 2 h or more may have potentially deleterious effects on cardiovascular biomarkers including blood pressure, as well as increasing the risk of falling. Vitality, vigour and fatigue, subscales of mood may also be adversely affected in older adults. These effects appear to increase with continuous sitting time.
ER -