Association of SDF-1β (rs1801157) and TCF7L2 (rs12255372) Gene Polymorphisms With Type 2 Diabetes Mellitus in the Bangladeshi Population: A Case-Control Study.
- 1Department of Pharmaceutical Sciences, School of Health & Life Sciences North South University Dhaka Bangladesh.
Abstract
Aims
Type 2 diabetes mellitus (T2DM) has a strong genetic component and variations in specific gene alleles can significantly influence individual susceptibility. Stromal cell-derived factor-1 beta (SDF-1β) plays a crucial role in inflammatory responses, glucose regulation, and the maintenance of pancreatic β-cell function, while TCF7L2, a key regulator of the Wnt signaling pathway, governs insulin secretion and overall glucose homeostasis. The present study evaluated the association of the SDF-1β rs1801157 and TCF7L2 rs12255372 polymorphisms with T2DM development in the Bangladeshi population.Methods
In this case-control study, 140 clinically diagnosed T2DM patients and 95 healthy controls, were enrolled after obtaining approval from the institutional ethics committee. Genomic DNA was genotyped for SDF-1β (rs1801157) and TCF7L2 (rs12255372) SNPs using PCR-RFLP, with MspI used for SDF-1β digestion and MluCI for the TCF7L2 fragment. The resulting genotypes were then identified through agarose gel electrophoresis. Hardy-Weinberg equilibrium was tested in both groups. Genotype and allele frequencies were compared using Fisher's exact test, with crude and adjusted (for age, sex, BMI) odds ratios (ORs).Results
All genotype distributions were in the Hardy-Weinberg equilibrium. Using the homozygous dominant genotype (GG) as the reference, a statistically significant association was observed for SDF-1β (rs1801157) with the AA genotype (p < 0.05), whereas TCF7L2 (rs12255372) showed no significant association. Additionally, the allele frequency distributions for both SDF-1β and TCF7L2 did not differ significantly between cases and controls (p > 0.05).Conclusions
The SDF-1β (rs1801157) AA genotype was significantly less frequent among T2DM patients, suggesting a possible protective association, whereas TCF7L2 (rs12255372) showed no such association. Given the modest sample size and limited statistical power, these findings indicate a possible association rather than a definitive marker of susceptibility and require replication.
Related
- Association of MDM2 rs2279744 and rs937282 polymorphisms with breast cancer susceptibility and circulating MDM2 and p53 levels in Bangladeshi women: A case-control study
- Association of TLR2 T597C, TLR4 A896G, and TLR9 G1174A gene polymorphisms with risk of pulmonary tuberculosis in the Ethiopian population: A case-control study
- Association of IL16 rs11556218 and IL1B rs16944 polymorphisms with type 2 diabetes in the Kinh Vietnamese population
- Association between H19 polymorphisms and susceptibility to pediatric central nervous system tumors in Chinese children
- Association of IL-6 and IL-10 serum levels with genetic variants in diabetic neuropathy: Clinical findings from a Bangladeshi patient cohort
BibTeX
@article{mobin2026association,
title = {{Association of SDF-1β (rs1801157) and TCF7L2 (rs12255372) Gene Polymorphisms With Type 2 Diabetes Mellitus in the Bangladeshi Population: A Case-Control Study.}},
author = {Md Abdullah Al Mobin and Shahriar Alam Shanto and Eamin Hasnayan and Sumaiya Zaman Prome and Obontika Das and Armin Afsar and Jarin Tasmin Ahmed Rechi and Asmaul Hosna Shaika and Fayejun Nesa and Mehedi Mala Mitu and Ferdous Khan and Md Hasanuzzaman Shohag},
journal = {Health science reports},
year = {2026},
month = oct,
doi = {10.1002/hsr2.73436},
url = {https://europepmc.org/article/MED/42936104},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Association of SDF-1β (rs1801157) and TCF7L2 (rs12255372) Gene Polymorphisms With Type 2 Diabetes Mellitus in the Bangladeshi Population: A Case-Control Study.
AU - Md Abdullah Al Mobin
AU - Shahriar Alam Shanto
AU - Eamin Hasnayan
AU - Sumaiya Zaman Prome
AU - Obontika Das
AU - Armin Afsar
AU - Jarin Tasmin Ahmed Rechi
AU - Asmaul Hosna Shaika
AU - Fayejun Nesa
AU - Mehedi Mala Mitu
AU - Ferdous Khan
AU - Md Hasanuzzaman Shohag
PY - 2026
DA - 2026/10/26
JO - Health science reports
DO - 10.1002/hsr2.73436
UR - https://europepmc.org/article/MED/42936104
AB - Aims Type 2 diabetes mellitus (T2DM) has a strong genetic component and variations in specific gene alleles can significantly influence individual susceptibility. Stromal cell-derived factor-1 beta (SDF-1β) plays a crucial role in inflammatory responses, glucose regulation, and the maintenance of pancreatic β-cell function, while TCF7L2, a key regulator of the Wnt signaling pathway, governs insulin secretion and overall glucose homeostasis. The present study evaluated the association of the SDF-1β rs1801157 and TCF7L2 rs12255372 polymorphisms with T2DM development in the Bangladeshi population.Methods In this case-control study, 140 clinically diagnosed T2DM patients and 95 healthy controls, were enrolled after obtaining approval from the institutional ethics committee. Genomic DNA was genotyped for SDF-1β (rs1801157) and TCF7L2 (rs12255372) SNPs using PCR-RFLP, with MspI used for SDF-1β digestion and MluCI for the TCF7L2 fragment. The resulting genotypes were then identified through agarose gel electrophoresis. Hardy-Weinberg equilibrium was tested in both groups. Genotype and allele frequencies were compared using Fisher's exact test, with crude and adjusted (for age, sex, BMI) odds ratios (ORs).Results All genotype distributions were in the Hardy-Weinberg equilibrium. Using the homozygous dominant genotype (GG) as the reference, a statistically significant association was observed for SDF-1β (rs1801157) with the AA genotype (p < 0.05), whereas TCF7L2 (rs12255372) showed no significant association. Additionally, the allele frequency distributions for both SDF-1β and TCF7L2 did not differ significantly between cases and controls (p > 0.05).Conclusions The SDF-1β (rs1801157) AA genotype was significantly less frequent among T2DM patients, suggesting a possible protective association, whereas TCF7L2 (rs12255372) showed no such association. Given the modest sample size and limited statistical power, these findings indicate a possible association rather than a definitive marker of susceptibility and require replication.
SN - 2398-8835
ER -