Predictive value of baseline hematological and platelet indices for visual and anatomical outcomes in retinal vein occlusion: a retrospective analysis.
- 1Department of Ophthalmology, Harran University Faculty of Medicine, Sanliurfa, Turkey. [email protected].
- 2Department of Ophthalmology, Harran University Faculty of Medicine, Sanliurfa, Turkey.
- 3Sanlıurfa Mehmet Akif İnan Training and Research Hospital, Sanliurfa, Türkiye.
Abstract
Purpose
To investigate the prognostic value of demographic characteristics, platelet activation markers, and systemic inflammatory indices in predicting anatomical and functional outcomes in patients with retinal vein occlusion (RVO) undergoing intravitreal therapy.Methods
The medical records of patients diagnosed with RVO and followed at the Department of Ophthalmology, Faculty of Medicine, Harran University, between January 2016 and January 2025 were retrospectively reviewed. After applying the inclusion and exclusion criteria, 65 eyes of 65 patients were included in the study. Patients were classified as having branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO) according to the site of venous occlusion. Baseline complete blood count parameters, platelet indices, including mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), as well as inflammatory indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), were recorded. Anatomical outcomes were assessed by changes in central macular thickness (ΔCMT), whereas functional outcomes were evaluated by changes in best-corrected visual acuity (ΔlogMAR). Statistical analyses were performed using SPSS version 27.0.Results
The mean age of the patients was 62.65 ± 11.49 years, and 48 patients (73.8%) had BRVO. Mean central macular thickness decreased from 668.6 ± 224.3 μm at baseline to 456.4 ± 227.4 μm at the final follow-up. A significant positive correlation was observed between ΔCMT and ΔlogMAR (r = 0.443, p < 0.001).MPV showed a significant positive correlation with the early anatomical response, as reflected by the change in CMT between baseline and the first follow-up (r = 0.290, p = 0.019). PCT was significantly correlated with final visual outcomes (r = 0.313, p = 0.011). No significant associations were found between other hematological parameters or inflammatory indices and anatomical or functional outcomes. The mean age of patients in the CRVO group was significantly lower than that of patients in the BRVO group (p = 0.049).Conclusions
Platelet activation markers may be associated with early anatomical response and final visual outcomes in patients with RVO. In particular, MPV and PCT may serve as potential biomarkers for predicting treatment response. Because these parameters are readily available from routine complete blood count testing, they may provide clinically useful information for prognostic assessment and individualized treatment planning in patients with RVO. Further large-scale, prospective, multicenter studies are warranted to validate these findings.
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BibTeX
@article{yuksekyayla2026predictive,
title = {{Predictive value of baseline hematological and platelet indices for visual and anatomical outcomes in retinal vein occlusion: a retrospective analysis.}},
author = {Funda Yüksekyayla and Ali Şimşek and Ali Hakim Reyhan and Çağri Mutaf and Irfan Uzun and Evin Esin Kamışlı},
journal = {International journal of retina and vitreous},
year = {2026},
month = jul,
doi = {10.1186/s40942-026-00905-3},
url = {https://europepmc.org/article/MED/42972464},
note = {CC BY},
}
RIS
TY - JOUR
TI - Predictive value of baseline hematological and platelet indices for visual and anatomical outcomes in retinal vein occlusion: a retrospective analysis.
AU - Funda Yüksekyayla
AU - Ali Şimşek
AU - Ali Hakim Reyhan
AU - Çağri Mutaf
AU - Irfan Uzun
AU - Evin Esin Kamışlı
PY - 2026
DA - 2026/07/01
JO - International journal of retina and vitreous
DO - 10.1186/s40942-026-00905-3
UR - https://europepmc.org/article/MED/42972464
AB - Purpose To investigate the prognostic value of demographic characteristics, platelet activation markers, and systemic inflammatory indices in predicting anatomical and functional outcomes in patients with retinal vein occlusion (RVO) undergoing intravitreal therapy.Methods The medical records of patients diagnosed with RVO and followed at the Department of Ophthalmology, Faculty of Medicine, Harran University, between January 2016 and January 2025 were retrospectively reviewed. After applying the inclusion and exclusion criteria, 65 eyes of 65 patients were included in the study. Patients were classified as having branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO) according to the site of venous occlusion. Baseline complete blood count parameters, platelet indices, including mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), as well as inflammatory indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR), were recorded. Anatomical outcomes were assessed by changes in central macular thickness (ΔCMT), whereas functional outcomes were evaluated by changes in best-corrected visual acuity (ΔlogMAR). Statistical analyses were performed using SPSS version 27.0.Results The mean age of the patients was 62.65 ± 11.49 years, and 48 patients (73.8%) had BRVO. Mean central macular thickness decreased from 668.6 ± 224.3 μm at baseline to 456.4 ± 227.4 μm at the final follow-up. A significant positive correlation was observed between ΔCMT and ΔlogMAR (r = 0.443, p < 0.001).MPV showed a significant positive correlation with the early anatomical response, as reflected by the change in CMT between baseline and the first follow-up (r = 0.290, p = 0.019). PCT was significantly correlated with final visual outcomes (r = 0.313, p = 0.011). No significant associations were found between other hematological parameters or inflammatory indices and anatomical or functional outcomes. The mean age of patients in the CRVO group was significantly lower than that of patients in the BRVO group (p = 0.049).Conclusions Platelet activation markers may be associated with early anatomical response and final visual outcomes in patients with RVO. In particular, MPV and PCT may serve as potential biomarkers for predicting treatment response. Because these parameters are readily available from routine complete blood count testing, they may provide clinically useful information for prognostic assessment and individualized treatment planning in patients with RVO. Further large-scale, prospective, multicenter studies are warranted to validate these findings.
SN - 2056-9920
ER -