Single-cell analysis reveals favorable responses of tumor-associated monocytes to bortezomib-based treatment in multiple myeloma.
5 affiliations
- 1Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. [email protected].
- 2Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
- 3Houston Methodist Research Institute, Houston, TX, USA.
- 4Edibeck Therapeutics Company Limited, Shenzhen, China. [email protected].
- 5Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. [email protected].
Abstract
The bone marrow microenvironment (BME) has a significant effect on bortezomib (BTZ)-based chemotherapy in patients with multiple myeloma (MM). However, how BME components drive effective BTZ-based chemotherapy to facilitate antitumor responses has yet to be fully understood. Using single-cell transcriptome analysis, we discerned a notable increase in the density of tumor-associated IL1B⁺ monocytes (TAMO_IL1B), a CD14⁺ monocyte subcluster, within the optimal responders (OR) group compared with the suboptimal responders (SOR) group. TAMO_IL1B in the OR group had significantly greater effects on the TGF-β signaling pathway. The ligand-receptor pair (THBS1-SDC1) interaction intensity in the THBS1 signaling pathway between TAMO_IL1B and tumor plasma cells (TPC) in the OR group was significantly greater than that in the SOR group. Furthermore, pseudotime trajectory analysis indicated that TAMO_IL1B predominantly occupied late differentiation stages and was associated with a favorable response within the OR group. These findings reveal a previously unrecognized role for TAMO_IL1B in shaping antitumor immunity. The THBS1-SDC1 axis may contribute to interactions between monocytes and plasma cells; however, functional validation is required before any therapeutic implications can be drawn.
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BibTeX
@article{cheng2026singlecell,
title = {{Single-cell analysis reveals favorable responses of tumor-associated monocytes to bortezomib-based treatment in multiple myeloma.}},
author = {Taofang Cheng and Huiqun Wu and Rui Jing and Yue Li and Rong Wei},
journal = {NPJ precision oncology},
year = {2026},
month = oct,
doi = {10.1038/s41698-026-01666-w},
url = {https://europepmc.org/article/MED/42957756},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Single-cell analysis reveals favorable responses of tumor-associated monocytes to bortezomib-based treatment in multiple myeloma.
AU - Taofang Cheng
AU - Huiqun Wu
AU - Rui Jing
AU - Yue Li
AU - Rong Wei
PY - 2026
DA - 2026/10/28
JO - NPJ precision oncology
DO - 10.1038/s41698-026-01666-w
UR - https://europepmc.org/article/MED/42957756
AB - The bone marrow microenvironment (BME) has a significant effect on bortezomib (BTZ)-based chemotherapy in patients with multiple myeloma (MM). However, how BME components drive effective BTZ-based chemotherapy to facilitate antitumor responses has yet to be fully understood. Using single-cell transcriptome analysis, we discerned a notable increase in the density of tumor-associated IL1B⁺ monocytes (TAMO_IL1B), a CD14⁺ monocyte subcluster, within the optimal responders (OR) group compared with the suboptimal responders (SOR) group. TAMO_IL1B in the OR group had significantly greater effects on the TGF-β signaling pathway. The ligand-receptor pair (THBS1-SDC1) interaction intensity in the THBS1 signaling pathway between TAMO_IL1B and tumor plasma cells (TPC) in the OR group was significantly greater than that in the SOR group. Furthermore, pseudotime trajectory analysis indicated that TAMO_IL1B predominantly occupied late differentiation stages and was associated with a favorable response within the OR group. These findings reveal a previously unrecognized role for TAMO_IL1B in shaping antitumor immunity. The THBS1-SDC1 axis may contribute to interactions between monocytes and plasma cells; however, functional validation is required before any therapeutic implications can be drawn.
SN - 2397-768X
ER -