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Peer-reviewedCC BY-NCScience Advances

Substrate-bound structures of yeast ALA synthase reveal protein dynamics initiating heme biosynthesis

  • Jenny U. Tran1
  • Thyandra A. Martinez2
  • Christopher Jurich3
  • Margaret R. Josling1
  • Julian M. Zhang1
  • Pedro H. Ayres-Galhardo2
  • Jens Meiler3,4,5
  • Zhongyue J. Yang3,4
  • Jason A. MacGurn2
  • Breann L. Brown1,4
5 affiliations
  1. 1Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, USA.
  2. 2Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.
  3. 3Department of Chemistry, Vanderbilt University, Nashville, TN, USA.
  4. 4Center for Structural Biology, Vanderbilt University, Nashville, TN, USA.
  5. 5Institute of Drug Discovery, Faculty of Medicine, University of Leipzig, 04103 Leipzig, Germany.
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Cite

BibTeXRIS
BibTeX
@article{tran2026substratebound,
  title = {{Substrate-bound structures of yeast ALA synthase reveal protein dynamics initiating heme biosynthesis}},
  author = {Jenny U. Tran and Thyandra A. Martinez and Christopher Jurich and Margaret R. Josling and Julian M. Zhang and Pedro H. Ayres-Galhardo and Jens Meiler and Zhongyue J. Yang and Jason A. MacGurn and Breann L. Brown},
  journal = {Science Advances},
  year = {2026},
  month = oct,
  doi = {10.1126/sciadv.aef7768},
  url = {https://www.science.org/doi/10.1126/sciadv.aef7768},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Substrate-bound structures of yeast ALA synthase reveal protein dynamics initiating heme biosynthesis
AU  - Jenny U. Tran
AU  - Thyandra A. Martinez
AU  - Christopher Jurich
AU  - Margaret R. Josling
AU  - Julian M. Zhang
AU  - Pedro H. Ayres-Galhardo
AU  - Jens Meiler
AU  - Zhongyue J. Yang
AU  - Jason A. MacGurn
AU  - Breann L. Brown
PY  - 2026
DA  - 2026/10/16
JO  - Science Advances
DO  - 10.1126/sciadv.aef7768
UR  - https://www.science.org/doi/10.1126/sciadv.aef7768
SN  - 2375-2548
ER  -