The sympathoadrenal contribution to inferior vena cava formation
Abstract
Although vascular development is fundamental during embryogenesis, the developmental basis and tissue interactions underlying anatomical variation in major veins are not fully understood. The renal segment of the inferior vena cava exhibits significant anatomical variations that often affect the safety of retroperitoneal surgery. Using mouse embryos, we show that the renal segment of the inferior vena cava is not primarily dependent on the subcardinal vein as classically proposed, but instead forms from a vascular plexus closely associated with the developing para-aortic ridge. Genetic models further indicate that sympathoadrenal development in the para-aortic ridge contributes to the proper organization and remodeling of this vascular network. This revised developmental framework highlights a sympathoadrenal–vascular coupling as a developmental basis for inferior vena cava formation and thereby challenges classical subcardinal vein-dependent models.
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BibTeX
@article{murashima2026sympathoadrenal,
title = {{The sympathoadrenal contribution to inferior vena cava formation}},
author = {Aki Murashima and Daisuke Matsumaru and Takashi Moriguchi and Yuichi Shima and Miki Inoue and Chikako Yokoyama and Ken-ichirou Morohashi and Yoshiaki Kubota and Takatoshi Ueki and Jiro Hitomi and Sumio Isogai},
journal = {Communications Biology},
year = {2026},
month = nov,
doi = {10.1038/s42003-026-11297-3},
url = {https://www.nature.com/articles/s42003-026-11297-3},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - The sympathoadrenal contribution to inferior vena cava formation
AU - Aki Murashima
AU - Daisuke Matsumaru
AU - Takashi Moriguchi
AU - Yuichi Shima
AU - Miki Inoue
AU - Chikako Yokoyama
AU - Ken-ichirou Morohashi
AU - Yoshiaki Kubota
AU - Takatoshi Ueki
AU - Jiro Hitomi
AU - Sumio Isogai
PY - 2026
DA - 2026/11/07
JO - Communications Biology
DO - 10.1038/s42003-026-11297-3
UR - https://www.nature.com/articles/s42003-026-11297-3
AB - Although vascular development is fundamental during embryogenesis, the developmental basis and tissue interactions underlying anatomical variation in major veins are not fully understood. The renal segment of the inferior vena cava exhibits significant anatomical variations that often affect the safety of retroperitoneal surgery. Using mouse embryos, we show that the renal segment of the inferior vena cava is not primarily dependent on the subcardinal vein as classically proposed, but instead forms from a vascular plexus closely associated with the developing para-aortic ridge. Genetic models further indicate that sympathoadrenal development in the para-aortic ridge contributes to the proper organization and remodeling of this vascular network. This revised developmental framework highlights a sympathoadrenal–vascular coupling as a developmental basis for inferior vena cava formation and thereby challenges classical subcardinal vein-dependent models.
SN - 2399-3642
ER -