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Peer-reviewedCC BY-NCAnnals of surgical treatment and research

Comparative clinical and molecular profiling of papillary thyroid carcinomas with unilateral and bilateral lateral lymph node metastasis: a retrospective cohort study.

  • Hyun-Il Shin1
  • Chan-Kwon Jung2
  • Young-Hoon Joo1
  • Ja-Seong Bae3
  1. 1Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  2. 2Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
  3. 3Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
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Abstract

Purpose

Studies on pathological and genetic features related to lateral lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) remain limited. This study aimed to elucidate these features.Methods

A total of 135 patients with PTC who underwent total thyroidectomy with lateral neck dissection between 2000 and 2021 were retrospectively analyzed. Next-generation sequencing-based mutation panel analysis was conducted for 26 cases with unilateral or bilateral LNM.Results

Contralateral central LNM ratio (P = 0.001) and extrathyroidal extension (P = 0.04) were significantly associated with contralateral lateral LNM. The cutoff value of central LNM ratio for predicting contralateral lateral LNM was 0.59 in total cases and 0.34 in contralateral cases. Receiver operating characteristic analysis demonstrated statistically significant but modest discrimination, with relatively low specificity. The bilateral group showed a broader distribution of genomic alterations, including copy number losses (e.g., FCGR2B, APOBEC3B) and enriched signaling pathways (RTK/RAS, Hippo, Notch). One bilateral case had a CCDC6::RET fusion.Conclusion

Bilateral LNM cases showed higher nodal burden and a broader distribution of genomic alterations in this limited cohort. These findings suggest potential biological heterogeneity in PTC with lateral LNM and warrant validation in larger studies.

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Cite

BibTeXRIS
BibTeX
@article{shin2026comparative,
  title = {{Comparative clinical and molecular profiling of papillary thyroid carcinomas with unilateral and bilateral lateral lymph node metastasis: a retrospective cohort study.}},
  author = {Hyun-Il Shin and Chan-Kwon Jung and Young-Hoon Joo and Ja-Seong Bae},
  journal = {Annals of surgical treatment and research},
  year = {2026},
  month = oct,
  doi = {10.4174/astr.2026.111.4.208},
  url = {https://europepmc.org/article/MED/42909234},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Comparative clinical and molecular profiling of papillary thyroid carcinomas with unilateral and bilateral lateral lymph node metastasis: a retrospective cohort study.
AU  - Hyun-Il Shin
AU  - Chan-Kwon Jung
AU  - Young-Hoon Joo
AU  - Ja-Seong Bae
PY  - 2026
DA  - 2026/10/08
JO  - Annals of surgical treatment and research
DO  - 10.4174/astr.2026.111.4.208
UR  - https://europepmc.org/article/MED/42909234
AB  - Purpose  Studies on pathological and genetic features related to lateral lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) remain limited. This study aimed to elucidate these features.Methods  A total of 135 patients with PTC who underwent total thyroidectomy with lateral neck dissection between 2000 and 2021 were retrospectively analyzed. Next-generation sequencing-based mutation panel analysis was conducted for 26 cases with unilateral or bilateral LNM.Results  Contralateral central LNM ratio (P = 0.001) and extrathyroidal extension (P = 0.04) were significantly associated with contralateral lateral LNM. The cutoff value of central LNM ratio for predicting contralateral lateral LNM was 0.59 in total cases and 0.34 in contralateral cases. Receiver operating characteristic analysis demonstrated statistically significant but modest discrimination, with relatively low specificity. The bilateral group showed a broader distribution of genomic alterations, including copy number losses (e.g., FCGR2B, APOBEC3B) and enriched signaling pathways (RTK/RAS, Hippo, Notch). One bilateral case had a CCDC6::RET fusion.Conclusion  Bilateral LNM cases showed higher nodal burden and a broader distribution of genomic alterations in this limited cohort. These findings suggest potential biological heterogeneity in PTC with lateral LNM and warrant validation in larger studies.
SN  - 2288-6575
SN  - 2288-6796
ER  -