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Peer-reviewedCC BYMicroPublication biology

Neurofibromin 1 alters feeding microstructure in Drosophila.

  • Zohre Panahidizjikan1
  • Sydney Born1
  • Maia Espinoza2,3
  • Tate Lillian4,3
  • Elizabeth B Brown1,5
5 affiliations
  1. 1Biological Sciences, Florida State University, Tallahassee, FL, United States.
  2. 2Miami Palmetto Senior High School, Pinecrest, FL, United States.
  3. 3Young Scholars Program, Florida State University, Tallahassee, FL, United States.
  4. 4Magnet Innovation Center, Inlet Beach, FL, USA.
  5. 5Program in Neuroscience, Florida State University, Tallahassee, FL, United States.
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Abstract

Neurofibromatosis type 1 (NF1) is caused by the loss of neurofibromin, a protein shown to regulate metabolism and feeding behavior in Drosophila melanogaster. Using the FlyPad two-choice feeding assay, we compared feeding microstructure between NF1 null mutants, NF1 heterozygotes, and wildtype controls. We find that NF1 mutants took significantly more sips of sucrose and with greater urgency, without changes in sip duration or sucrose taste sensitivity. Overall, these results suggest loss of NF1 increases feeding frequency.

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Cite

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BibTeX
@article{panahidizjikan2026neurofibromin,
  title = {{Neurofibromin 1 alters feeding microstructure in Drosophila.}},
  author = {Zohre Panahidizjikan and Sydney Born and Maia Espinoza and Tate Lillian and Elizabeth B Brown},
  journal = {MicroPublication biology},
  year = {2026},
  month = oct,
  doi = {10.17912/micropub.biology.002374},
  url = {https://europepmc.org/article/MED/42997200},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Neurofibromin 1 alters feeding microstructure in Drosophila.
AU  - Zohre Panahidizjikan
AU  - Sydney Born
AU  - Maia Espinoza
AU  - Tate Lillian
AU  - Elizabeth B Brown
PY  - 2026
DA  - 2026/10/21
JO  - MicroPublication biology
DO  - 10.17912/micropub.biology.002374
UR  - https://europepmc.org/article/MED/42997200
AB  - Neurofibromatosis type 1 (NF1) is caused by the loss of neurofibromin, a protein shown to regulate metabolism and feeding behavior in Drosophila melanogaster. Using the FlyPad two-choice feeding assay, we compared feeding microstructure between NF1 null mutants, NF1 heterozygotes, and wildtype controls. We find that NF1 mutants took significantly more sips of sucrose and with greater urgency, without changes in sip duration or sucrose taste sensitivity. Overall, these results suggest loss of NF1 increases feeding frequency.
SN  - 2578-9430
ER  -