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Peer-reviewedCC BY-NCAnnals of dermatology

Efficacy of Calcipotriol/Betamethasone Ointment in the Management of Pediatric Alopecia Areata.

  • Yumi Won1,2
  • Jungsoo Lee1,3
  • Hoonsoo Kim1,2,4
  • Hyunchang Ko1,3
  • Byungsoo Kim1,2,4
  • Moon-Bum Kim1,2,5
5 affiliations
  1. 1Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea.
  2. 2Department of Dermatology, Pusan National University Hospital, Busan, Korea.
  3. 3Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
  4. 4Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
  5. 5Biomedical Research Institute, Pusan National University Hospital, Busan, Korea. [email protected].
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Abstract

Background

Topical corticosteroids are acknowledged as the first-line treatment for pediatric alopecia areata. There are cases that are recalcitrant to topical corticosteroid application.Objective

The objective was to evaluate the efficacy of calcipotriol/betamethasone ointment in pediatric alopecia areata.Methods

In a 12-week retrospective study, 40 patients under 10 years old with alopecia areata were included. The patients were treated with a topical ointment combining 0.005% calcipotriol and betamethasone dipropionate once daily. The efficacy was monitored through changes in Severity of Alopecia Tool (SALT) scores.Results

The 40 patients, with a mean age of 4.1±2.1 years, were categorized by their SALT scores into two groups: those above and below 50. Patients with SALT scores over 50 showed hair regrowth in 7.44±4.44 weeks, while those with SALT scores under 50 showed regrowth in 5.71±2.58 weeks. After 12 weeks, 80.0% of the patients showed hair regrowth and 20.0% of patients showed no response or worsening. Only minor adverse events were documented during follow-up.Conclusion

Calcipotriol/betamethasone ointment may represent a useful topical option for pediatric alopecia areata.

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Cite

BibTeXRIS
BibTeX
@article{won2026efficacy,
  title = {{Efficacy of Calcipotriol/Betamethasone Ointment in the Management of Pediatric Alopecia Areata.}},
  author = {Yumi Won and Jungsoo Lee and Hoonsoo Kim and Hyunchang Ko and Byungsoo Kim and Moon-Bum Kim},
  journal = {Annals of dermatology},
  year = {2026},
  month = oct,
  doi = {10.5021/ad.26.016},
  url = {https://europepmc.org/article/MED/42845204},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Efficacy of Calcipotriol/Betamethasone Ointment in the Management of Pediatric Alopecia Areata.
AU  - Yumi Won
AU  - Jungsoo Lee
AU  - Hoonsoo Kim
AU  - Hyunchang Ko
AU  - Byungsoo Kim
AU  - Moon-Bum Kim
PY  - 2026
DA  - 2026/10/01
JO  - Annals of dermatology
DO  - 10.5021/ad.26.016
UR  - https://europepmc.org/article/MED/42845204
AB  - Background  Topical corticosteroids are acknowledged as the first-line treatment for pediatric alopecia areata. There are cases that are recalcitrant to topical corticosteroid application.Objective  The objective was to evaluate the efficacy of calcipotriol/betamethasone ointment in pediatric alopecia areata.Methods  In a 12-week retrospective study, 40 patients under 10 years old with alopecia areata were included. The patients were treated with a topical ointment combining 0.005% calcipotriol and betamethasone dipropionate once daily. The efficacy was monitored through changes in Severity of Alopecia Tool (SALT) scores.Results  The 40 patients, with a mean age of 4.1±2.1 years, were categorized by their SALT scores into two groups: those above and below 50. Patients with SALT scores over 50 showed hair regrowth in 7.44±4.44 weeks, while those with SALT scores under 50 showed regrowth in 5.71±2.58 weeks. After 12 weeks, 80.0% of the patients showed hair regrowth and 20.0% of patients showed no response or worsening. Only minor adverse events were documented during follow-up.Conclusion  Calcipotriol/betamethasone ointment may represent a useful topical option for pediatric alopecia areata.
SN  - 1013-9087
SN  - 2005-3894
ER  -