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Peer-reviewedCC BY-NC-NDPreventive medicine reports

Association between dual sensory impairments and new-onset cardiovascular disease among American middle-aged and older adults: the mediating role of depression.

  • Ziyan Lou1,2,3
  • Xuan Chen1,2,3
  • Xiaomin Wu1,2,3
  • Xinze Han1,2,3
  • Luhan Zhang1,2,3
  • Chenyu Li1,2,3
  • Jing Yuan1,2,3
  • Fei Ma1,2,3
  1. 1Department of Epidemiology & Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.
  2. 2Key Laboratory of Prevention and Control of Major Disease in the Population, Ministry of Education, Tianjin Medical University, Tianjin, China.
  3. 3Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China.
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Abstract

Objective

This study aimed to explore the association between dual sensory impairment (DSI) and incident cardiovascular disease (CVD), and to evaluate the potential mediating role of depression in this relationship.Methods

The data were sourced from 2017/2018 (Wave 14) to 2021/2022 (Wave 16) of the University of Michigan Health and Retirement Study (HRS) of the American aged 50 and above. A counterfactual-based causal mediation framework was employed to evaluate the mediating role of continuous depression scores in the association between DSI and new-onset CVD.Results

A total of 7582 participants were included, the incidence density of CVD is 23.67/1000 person-years. Compared with the people without VI (vision impairment) and HI (hearing impairment), those with DSI were associated with a significantly higher risk of CVD (HR: 1.52, 95%CI: 1.25, 1.85). Specifically, DSI was associated with a higher risk of cardiac events (HR: 1.41, 95%CI: 1.14, 1.75) and stroke (HR: 2.25, 95%CI: 1.50, 3.36). Notably, depression mediated 25.33% of the association between DSI and new-onset CVD. Mediation effects for cardiac events and stroke were 27.04% and 17.39%, respectively.Conclusion

DSI was associated with a higher risk of CVD among middle-aged and older adults. The association was partially mediated by depression.

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Cite

BibTeXRIS
BibTeX
@article{lou2026association,
  title = {{Association between dual sensory impairments and new-onset cardiovascular disease among American middle-aged and older adults: the mediating role of depression.}},
  author = {Ziyan Lou and Xuan Chen and Xiaomin Wu and Xinze Han and Luhan Zhang and Chenyu Li and Jing Yuan and Fei Ma},
  journal = {Preventive medicine reports},
  year = {2026},
  month = oct,
  doi = {10.1016/j.pmedr.2026.103659},
  url = {https://europepmc.org/article/MED/42904116},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Association between dual sensory impairments and new-onset cardiovascular disease among American middle-aged and older adults: the mediating role of depression.
AU  - Ziyan Lou
AU  - Xuan Chen
AU  - Xiaomin Wu
AU  - Xinze Han
AU  - Luhan Zhang
AU  - Chenyu Li
AU  - Jing Yuan
AU  - Fei Ma
PY  - 2026
DA  - 2026/10/10
JO  - Preventive medicine reports
DO  - 10.1016/j.pmedr.2026.103659
UR  - https://europepmc.org/article/MED/42904116
AB  - Objective  This study aimed to explore the association between dual sensory impairment (DSI) and incident cardiovascular disease (CVD), and to evaluate the potential mediating role of depression in this relationship.Methods  The data were sourced from 2017/2018 (Wave 14) to 2021/2022 (Wave 16) of the University of Michigan Health and Retirement Study (HRS) of the American aged 50 and above. A counterfactual-based causal mediation framework was employed to evaluate the mediating role of continuous depression scores in the association between DSI and new-onset CVD.Results  A total of 7582 participants were included, the incidence density of CVD is 23.67/1000 person-years. Compared with the people without VI (vision impairment) and HI (hearing impairment), those with DSI were associated with a significantly higher risk of CVD (HR: 1.52, 95%CI: 1.25, 1.85). Specifically, DSI was associated with a higher risk of cardiac events (HR: 1.41, 95%CI: 1.14, 1.75) and stroke (HR: 2.25, 95%CI: 1.50, 3.36). Notably, depression mediated 25.33% of the association between DSI and new-onset CVD. Mediation effects for cardiac events and stroke were 27.04% and 17.39%, respectively.Conclusion  DSI was associated with a higher risk of CVD among middle-aged and older adults. The association was partially mediated by depression.
SN  - 2211-3355
ER  -