Expression of COL6A1 in Tumor Matrix of Cholangiocarcinoma and Its Mechanism of Tumor Progression.
- 1Jinzhou Central Hospital, Jinzhou, Liaoning, China.
- 2Graduate School, Jinzhou Medical University Postgraduate Training Base (Jinzhou Central Hospital), Jinzhou, Liaoning, China.
- 3Department of Radiology, Jinzhou Maternal and Infant Hospital, Jinzhou, Liaoning, China.
Abstract
Background
Cholangiocarcinoma (CCA), a malignant tumor originating from the bile duct epithelial cells, is characterized by aggressive invasion and poor prognosis. Abnormal remodeling of the tumor microenvironment plays a pivotal role in its disease progression. The tumor stroma, which is a core component of the tumor microenvironment, comprises an extracellular matrix and various stromal cells. Changes in its composition are closely associated with tumor proliferation, invasion, metastasis, and drug resistance. Collagen Type VI alpha 1 chain (COL6A1), an important functional protein in the extracellular matrix, plays a carcinogenic role in multiple malignant tumors; it participates in matrix remodeling and cellular signaling and influences the tumor immune microenvironment. This systematic review aims to examine the biological properties of COL6A1 and the structural characteristics of CCA tumor stroma, and summarize the roles of stromal COL6A1 in CCA.Recent findings
We outline the expression patterns of stromal COL6A1 in CCA and its correlation with clinicopathological features. Specifically, we systematically discuss the molecular mechanisms by which COL6A1 facilitates CCA progression, including mediating stromal remodeling, cancer-associated fibroblast activation, oncogenic signaling cascades, the immunosuppressive microenvironment, and therapeutic resistance. COL6A1 shows translational potential as a diagnostic biomarker, staging indicator, and prognostic predictor for CCA.Conclusion
COL6A1 is a critical molecule regulating stromal remodeling and malignant progression of CCA. This review highlights the current research gaps and proposes prospective research directions, providing a theoretical foundation for future investigations and clinical translations using COL6A1 in CCA.
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BibTeX
@article{zhang2026expression,
title = {{Expression of COL6A1 in Tumor Matrix of Cholangiocarcinoma and Its Mechanism of Tumor Progression.}},
author = {Weibin Zhang and Chongshi Gao and Chongzhou Lan and Jia Dong and Boxing Xu and Yingmei Li and Jin Dai and Baitong Che and Cheng Li and Gang Dong and Yunfei Wu and Bo Li and Cheng Yang and Lingmei Kong},
journal = {Cancer reports (Hoboken, N.J.)},
year = {2026},
month = oct,
doi = {10.1002/cnr2.70716},
url = {https://europepmc.org/article/MED/42852948},
note = {CC BY},
}
RIS
TY - JOUR
TI - Expression of COL6A1 in Tumor Matrix of Cholangiocarcinoma and Its Mechanism of Tumor Progression.
AU - Weibin Zhang
AU - Chongshi Gao
AU - Chongzhou Lan
AU - Jia Dong
AU - Boxing Xu
AU - Yingmei Li
AU - Jin Dai
AU - Baitong Che
AU - Cheng Li
AU - Gang Dong
AU - Yunfei Wu
AU - Bo Li
AU - Cheng Yang
AU - Lingmei Kong
PY - 2026
DA - 2026/10/01
JO - Cancer reports (Hoboken, N.J.)
DO - 10.1002/cnr2.70716
UR - https://europepmc.org/article/MED/42852948
AB - Background Cholangiocarcinoma (CCA), a malignant tumor originating from the bile duct epithelial cells, is characterized by aggressive invasion and poor prognosis. Abnormal remodeling of the tumor microenvironment plays a pivotal role in its disease progression. The tumor stroma, which is a core component of the tumor microenvironment, comprises an extracellular matrix and various stromal cells. Changes in its composition are closely associated with tumor proliferation, invasion, metastasis, and drug resistance. Collagen Type VI alpha 1 chain (COL6A1), an important functional protein in the extracellular matrix, plays a carcinogenic role in multiple malignant tumors; it participates in matrix remodeling and cellular signaling and influences the tumor immune microenvironment. This systematic review aims to examine the biological properties of COL6A1 and the structural characteristics of CCA tumor stroma, and summarize the roles of stromal COL6A1 in CCA.Recent findings We outline the expression patterns of stromal COL6A1 in CCA and its correlation with clinicopathological features. Specifically, we systematically discuss the molecular mechanisms by which COL6A1 facilitates CCA progression, including mediating stromal remodeling, cancer-associated fibroblast activation, oncogenic signaling cascades, the immunosuppressive microenvironment, and therapeutic resistance. COL6A1 shows translational potential as a diagnostic biomarker, staging indicator, and prognostic predictor for CCA.Conclusion COL6A1 is a critical molecule regulating stromal remodeling and malignant progression of CCA. This review highlights the current research gaps and proposes prospective research directions, providing a theoretical foundation for future investigations and clinical translations using COL6A1 in CCA.
SN - 2573-8348
ER -