Photocatalytic Synthesis of Pentafluorosulfanyl Ketones, Acetals, and BCP Motifs Utilizing SF 6
5 affiliations
- 1Department of Chemistry University of Science and Technology of China Hefei China
- 2Department of Pharmacy Division of Life Sciences and Medicine The First Affiliated Hospital of USTC University of Science and Technology of China Hefei China
- 3State Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences Shanghai China
- 4State Grid Anhui electric Power Research Institute Hefei Anhui China
- 5School of Chemistry and Materials Science Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences Hangzhou China
Abstract
Sulfur hexafluoride (SF 6 ), a chemically inert and stable gas essential to the electric power industry, poses severe environmental risks due to its persistence and high global warming potential. While traditional degradation methods are inefficient, photocatalytic single electron reduction (SER) enables SF 6 activation into SF 5 radicals, creating opportunities for both degradation and reutilization. The SF 5 group, renowned for its strong electron‐withdrawing, lipophilic, and bioisosteric features, has great potential in drug discovery, while efficient methods for synthesizing alkyl‐ or BCP‐SF 5 motifs remain scarce. As a safe, inexpensive, and atom‐economical alternative to conventional SF 5 reagents, SF 6 serves as an ideal yet underexplored SF 5 source. Herein, we present a photocatalytic strategy for the direct synthesis of diverse SF 5 ‐containing scaffolds, including ketones, acetals, and bicyclo[1.1.1]pentane derivatives. Derivatization studies demonstrate its synthetic versatility, particularly in accessing α‐SF 5 ‐substituted acetaldehydes. Mechanistic and density functional theory (DFT) studies confirm the single electron reduction of SF 6 , highlighting a mild, efficient, and broadly applicable route for constructing SF 5 ‐functionalized architectures in fluorinated drug development.
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BibTeX
@article{jiang2026photocatalytic,
title = {{Photocatalytic Synthesis of Pentafluorosulfanyl Ketones, Acetals, and BCP Motifs Utilizing SF 6}},
author = {Chen‐Hui Jiang and HJ Xu and Yang Yi-gang and Xuan Nie and Meng-Meng Zheng and Yue Zhao and Ya-Wen Zuo and Wei‐Ran Ren and Shan Zhu and Ruo‐Xing Jin and Xiao‐Song Xue and Xi-Sheng Wang},
journal = {Advanced Science},
year = {2026},
month = may,
doi = {10.1002/advs.75663},
url = {https://doi.org/10.1002/advs.75663},
note = {CC BY},
}
RIS
TY - JOUR
TI - Photocatalytic Synthesis of Pentafluorosulfanyl Ketones, Acetals, and BCP Motifs Utilizing SF 6
AU - Chen‐Hui Jiang
AU - HJ Xu
AU - Yang Yi-gang
AU - Xuan Nie
AU - Meng-Meng Zheng
AU - Yue Zhao
AU - Ya-Wen Zuo
AU - Wei‐Ran Ren
AU - Shan Zhu
AU - Ruo‐Xing Jin
AU - Xiao‐Song Xue
AU - Xi-Sheng Wang
PY - 2026
DA - 2026/05/15
JO - Advanced Science
DO - 10.1002/advs.75663
UR - https://doi.org/10.1002/advs.75663
AB - Sulfur hexafluoride (SF 6 ), a chemically inert and stable gas essential to the electric power industry, poses severe environmental risks due to its persistence and high global warming potential. While traditional degradation methods are inefficient, photocatalytic single electron reduction (SER) enables SF 6 activation into SF 5 radicals, creating opportunities for both degradation and reutilization. The SF 5 group, renowned for its strong electron‐withdrawing, lipophilic, and bioisosteric features, has great potential in drug discovery, while efficient methods for synthesizing alkyl‐ or BCP‐SF 5 motifs remain scarce. As a safe, inexpensive, and atom‐economical alternative to conventional SF 5 reagents, SF 6 serves as an ideal yet underexplored SF 5 source. Herein, we present a photocatalytic strategy for the direct synthesis of diverse SF 5 ‐containing scaffolds, including ketones, acetals, and bicyclo[1.1.1]pentane derivatives. Derivatization studies demonstrate its synthetic versatility, particularly in accessing α‐SF 5 ‐substituted acetaldehydes. Mechanistic and density functional theory (DFT) studies confirm the single electron reduction of SF 6 , highlighting a mild, efficient, and broadly applicable route for constructing SF 5 ‐functionalized architectures in fluorinated drug development.
SN - 2198-3844
ER -