Pregnancy after transcatheter closure of atrial septal defects: safety and clinical outcomes
- 1Department of Cardiac and Vascular Diseases, St. John Paul II Hospital, Krakow, Poland
- 2Department of Transplantology and Mechanical Circulatory Support, St. John Paul II Hospital, Krakow, Poland
- 3Faculty of Medicine, Medical College, Jagiellonian University Krakow, Poland
Abstract
Introduction: In recent years, there has been rapid development of minimally invasive cardiovascular procedures, such as atrial septal defect (ASD) transcatheter closure. Many female patients of reproductive age have undergone this procedure, but evidence regarding pregnancy outcomes after transcatheter closure of ASD remains limited.
Aim: Our aim was to assess maternal and fetal outcomes and investigate the magnitude and determinants of obstetric complications in patients after transcatheter closure of an ASD.
Material and methods: We analyzed 130 women with an average age of 28.6 ±9.1 years (19–44) who underwent ASD transcatheter closure using the Amplatzer Septal Occluder. Detailed records of each pregnancy (n = 130), occurring an average of 18.2 ±4.1 months (11–35) after transcatheter closure, were analyzed. Cardiac events were defined as heart failure exacerbation, stroke, transient ischemic attack (TIA), arrhythmias, or endocarditis; obstetric events as pregnancy-induced hypertension (PIH), preeclampsia, HELLP syndrome, premature labor, or postpartum hemorrhage; neonatal events as premature delivery, small-for-gestational age, or fetal or neonatal morbidity or mortality.
Results: Cardiac events were observed during 20.8% (n = 27) of pregnancies and included supraventricular arrhythmias (n = 24, 18.5%) and severe peripheral edema (n = 3, 2.3%). Obstetric events occurred in 22 (16.9%) patients. Neonatal events complicated only 2 (1.5%) pregnancies.
Conclusions: Most pregnancies after transcatheter ASD closure with the Amplatzer Septal Occluder were completed successfully, with favorable obstetric and neonatal outcomes. Maternal complications were more common among women aged over 30 years.
Related
- A Large Retrospective Study to Evaluate Utility of Zephyr Covered Stent in Transcatheter Closure of Sinus Venosus Defects
- Clinical Outcomes of Transcatheter Versus Surgical Aortic Valve Replacement in Patients with Pure Native Aortic Regurgitation: A Systematic Review and Meta-Analysis
- Longitudinal Trajectories of the Atherogenic Index of Plasma and Their Associations with Clinical Outcomes After Transcatheter Aortic Valve Replacement
- Impact of prolonged balloon inflation on valve expansion and early clinical outcomes following contemporary balloon-expandable transcatheter aortic valve implantation
- Distally Based Adipofascial Flaps for Reconstruction of Distal Lower-Extremity Defects: Clinical Outcomes and Reconstructive Considerations
BibTeX
@article{trojanowicz2026pregnancy,
title = {{Pregnancy after transcatheter closure of atrial septal defects: safety and clinical outcomes}},
author = {Katarzyna Trojanowicz and Paweł Prochownik and Michał Tworek and Zuzanna Sachajko and Klaudia Bielecka and Urszula Gancarczyk and Bartosz Sobień and Larysa Bielecka and Monika Komar},
journal = {Postepy w kardiologii interwencyjnej = Advances in interventional cardiology},
year = {2026},
month = sep,
doi = {10.5114/aic.2026.164803},
url = {https://europepmc.org/article/PMC/PMC13721051},
note = {CC BY-NC-SA},
}
RIS
TY - JOUR
TI - Pregnancy after transcatheter closure of atrial septal defects: safety and clinical outcomes
AU - Katarzyna Trojanowicz
AU - Paweł Prochownik
AU - Michał Tworek
AU - Zuzanna Sachajko
AU - Klaudia Bielecka
AU - Urszula Gancarczyk
AU - Bartosz Sobień
AU - Larysa Bielecka
AU - Monika Komar
PY - 2026
DA - 2026/09/01
JO - Postepy w kardiologii interwencyjnej = Advances in interventional cardiology
DO - 10.5114/aic.2026.164803
UR - https://europepmc.org/article/PMC/PMC13721051
AB - Introduction: In recent years, there has been rapid development of minimally invasive cardiovascular procedures, such as atrial septal defect (ASD) transcatheter closure. Many female patients of reproductive age have undergone this procedure, but evidence regarding pregnancy outcomes after transcatheter closure of ASD remains limited. Aim: Our aim was to assess maternal and fetal outcomes and investigate the magnitude and determinants of obstetric complications in patients after transcatheter closure of an ASD. Material and methods: We analyzed 130 women with an average age of 28.6 ±9.1 years (19–44) who underwent ASD transcatheter closure using the Amplatzer Septal Occluder. Detailed records of each pregnancy (n = 130), occurring an average of 18.2 ±4.1 months (11–35) after transcatheter closure, were analyzed. Cardiac events were defined as heart failure exacerbation, stroke, transient ischemic attack (TIA), arrhythmias, or endocarditis; obstetric events as pregnancy-induced hypertension (PIH), preeclampsia, HELLP syndrome, premature labor, or postpartum hemorrhage; neonatal events as premature delivery, small-for-gestational age, or fetal or neonatal morbidity or mortality. Results: Cardiac events were observed during 20.8% (n = 27) of pregnancies and included supraventricular arrhythmias (n = 24, 18.5%) and severe peripheral edema (n = 3, 2.3%). Obstetric events occurred in 22 (16.9%) patients. Neonatal events complicated only 2 (1.5%) pregnancies. Conclusions: Most pregnancies after transcatheter ASD closure with the Amplatzer Septal Occluder were completed successfully, with favorable obstetric and neonatal outcomes. Maternal complications were more common among women aged over 30 years.
SN - 1734-9338
SN - 1897-4295
ER -