Vitamin D status and inflammatory Interleukins in women with and without polyendocrine metabolic ovarian syndrome: a cross-sectional exploratory study.
5 affiliations
- 1Department of Basic Scientific Sciences, Al-Balqa Applied University, Irbid, Jordan.
- 2Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
- 3Department of Obstetrics and Gynecology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
- 4School of Pharmacy, Jadara University, Irbid, Jordan.
- 5Department of Obstetrics and Gynecology, Jordanian Royal Medical Services, Prince Rashid Ben AlHasan Military Hospital, Aydoun, Jordan.
Abstract
Background
Polyendocrine Metabolic Ovarian Syndrome (PMOS), formerly referred to as polycystic ovary syndrome (PCOS), is an intricate endocrine disorder, defined by a constellation of hormonal, metabolic, and reproductive irregularities. Vitamin D deficiency and increased levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) have been implicated in the pathogenesis of PMOS. Although vitamin D deficiency and low-grade inflammation have each been associated with PMOS, the relationship between vitamin D status and circulating inflammatory cytokines remains incompletely characterized. Thus, this study aimed to investigate the association of Vitamin D and inflammatory interleukins believed to play a key role in the pathogenesis of PMOS.Method
The study involved 94 participants divided into two groups: 44 PMOS patients and 50 healthy controls. Age and BMI were recorded for each patient and plasma levels of Vitamin D, anti-Müllerian hormone (AMH), IL-6, and IL-8 were measured and compared between the two groups using the Enzyme-Linked Immunosorbent Assay.Results
AMH (p < 0.02), IL-6 (p < 0.001) and IL-8 (p < 0.001) levels were significantly higher in PMOS patients than in controls. Lastly, vitamin D levels were found significantly lower in PMOS patients (18.59 ng/mL) than in controls (37.95 ng/mL; p < 0.001). However, no significant correlation was found between IL-6, IL-8 and Vitamin D.Conclusion
Women with PMOS characterized by lower vitamin D concentrations alongside higher AMH, IL-6, IL-8, and BMI compared to healthy controls. Larger longitudinal and prospective interventional studies are required to clarify causality and determine if vitamin D supplementation improves clinical outcomes.
Related
- Triglyceride-Glucose Index and Systemic Inflammatory Markers in Polyendocrine Metabolic Ovarian Syndrome (Polycystic Ovary Syndrome): A Cross-Sectional Study
- Blood Cytokine Profiling Reveals Distinct Inflammatory Signatures in Phenotypes A and B of Polyendocrine Metabolic Ovarian Syndrome (PMOS; formerly PCOS).
- Is There a Correlation Between Inflammatory Markers and Anti-Müllerian Hormone Level in Non-Obese Patients with Polyendocrine Metabolic Ovarian Syndrome?
- Knowledge, Attitudes, and Practices Related to Polyendocrine Metabolic Ovarian Syndrome Among Women with PMOS in Jiangsu Province, China: A Cross-sectional Study
- Knowledge gaps regarding polycystic ovary syndrome/polyendocrine metabolic ovarian syndrome among medical students: a cross-sectional study
BibTeX
@article{bdeir2026vitamin,
title = {{Vitamin D status and inflammatory Interleukins in women with and without polyendocrine metabolic ovarian syndrome: a cross-sectional exploratory study.}},
author = {Roba Bdeir and Nour Al-Sawalha and Hasan Rawashdeh and Ruba Malkawi and Ola Alrousan},
journal = {Annals of medicine},
year = {2026},
month = oct,
doi = {10.1080/07853890.2026.2749018},
url = {https://europepmc.org/article/MED/42872560},
note = {CC BY},
}
RIS
TY - JOUR
TI - Vitamin D status and inflammatory Interleukins in women with and without polyendocrine metabolic ovarian syndrome: a cross-sectional exploratory study.
AU - Roba Bdeir
AU - Nour Al-Sawalha
AU - Hasan Rawashdeh
AU - Ruba Malkawi
AU - Ola Alrousan
PY - 2026
DA - 2026/10/14
JO - Annals of medicine
DO - 10.1080/07853890.2026.2749018
UR - https://europepmc.org/article/MED/42872560
AB - Background Polyendocrine Metabolic Ovarian Syndrome (PMOS), formerly referred to as polycystic ovary syndrome (PCOS), is an intricate endocrine disorder, defined by a constellation of hormonal, metabolic, and reproductive irregularities. Vitamin D deficiency and increased levels of interleukin-6 (IL-6) and interleukin-8 (IL-8) have been implicated in the pathogenesis of PMOS. Although vitamin D deficiency and low-grade inflammation have each been associated with PMOS, the relationship between vitamin D status and circulating inflammatory cytokines remains incompletely characterized. Thus, this study aimed to investigate the association of Vitamin D and inflammatory interleukins believed to play a key role in the pathogenesis of PMOS.Method The study involved 94 participants divided into two groups: 44 PMOS patients and 50 healthy controls. Age and BMI were recorded for each patient and plasma levels of Vitamin D, anti-Müllerian hormone (AMH), IL-6, and IL-8 were measured and compared between the two groups using the Enzyme-Linked Immunosorbent Assay.Results AMH (p < 0.02), IL-6 (p < 0.001) and IL-8 (p < 0.001) levels were significantly higher in PMOS patients than in controls. Lastly, vitamin D levels were found significantly lower in PMOS patients (18.59 ng/mL) than in controls (37.95 ng/mL; p < 0.001). However, no significant correlation was found between IL-6, IL-8 and Vitamin D.Conclusion Women with PMOS characterized by lower vitamin D concentrations alongside higher AMH, IL-6, IL-8, and BMI compared to healthy controls. Larger longitudinal and prospective interventional studies are required to clarify causality and determine if vitamin D supplementation improves clinical outcomes.
SN - 0785-3890
SN - 1365-2060
ER -