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Peer-reviewedCC BY 4.0Reviews in Cardiovascular Medicine

Advances in Mechanisms and Management Strategies of Pulmonary Hypertension: A Review

  • Anqi Liu1,2
  • Linfeng Xi3,4
  • Jie Du1,2
  • Yanlin Guo2
  • Hanchi Yu5
  • Shuai Zhang3
  • Wanmu Xie3
  • Min Liu2,4
5 affiliations
  1. 1Chinese Academy of Medical Sciences & Peking Union Medical College, 100730 Beijing, China
  2. 2Department of Radiology, China-Japan Friendship Hospital, 100029 Beijing, China
  3. 3Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital; National Center for Respiratory Medicine; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; National Clinical Research Center for Respiratory Diseases, 100029 Beijing, China
  4. 4State Key Laboratory of Respiratory Health and Multimorbidity, China-Japan Friendship Hospital, 100029 Beijing, China
  5. 5Peking University Health Science Center, 100191 Beijing, China
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Abstract

Pulmonary hypertension (PH) encompasses a heterogeneous group of disorders characterized by persistently elevated pulmonary artery pressure and driven by diverse etiologies and intersecting pathological mechanisms. In recent years, substantial advances have clarified key contributors to PH pathogenesis, including pulmonary vascular remodeling, immune–inflammatory dysregulation, and genetic predispositions. Concurrently, diagnostic and therapeutic approaches tailored to different PH subtypes have evolved, incorporating targeted pharmacological treatments, interventional procedures, and lung transplantation. This review summarizes recent advances in elucidating the mechanisms underlying PH and outlines clinical management strategies across the major etiologic categories. Particular emphasis is placed on developments in PH-specific therapies and on emerging therapeutic targets to provide a coherent mechanistic framework and practical guidance for clinicians involved in the diagnosis and treatment of this challenging disease.

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Cite

BibTeXRIS
BibTeX
@article{liu2026advances,
  title = {{Advances in Mechanisms and Management Strategies of Pulmonary Hypertension: A Review}},
  author = {Anqi Liu and Linfeng Xi and Jie Du and Yanlin Guo and Hanchi Yu and Shuai Zhang and Wanmu Xie and Min Liu},
  journal = {Reviews in Cardiovascular Medicine},
  year = {2026},
  month = oct,
  doi = {10.31083/rcm49075},
  url = {https://doi.org/10.31083/rcm49075},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Advances in Mechanisms and Management Strategies of Pulmonary Hypertension: A Review
AU  - Anqi Liu
AU  - Linfeng Xi
AU  - Jie Du
AU  - Yanlin Guo
AU  - Hanchi Yu
AU  - Shuai Zhang
AU  - Wanmu Xie
AU  - Min Liu
PY  - 2026
DA  - 2026/10/14
JO  - Reviews in Cardiovascular Medicine
DO  - 10.31083/rcm49075
UR  - https://doi.org/10.31083/rcm49075
AB  - Pulmonary hypertension (PH) encompasses a heterogeneous group of disorders characterized by persistently elevated pulmonary artery pressure and driven by diverse etiologies and intersecting pathological mechanisms. In recent years, substantial advances have clarified key contributors to PH pathogenesis, including pulmonary vascular remodeling, immune–inflammatory dysregulation, and genetic predispositions. Concurrently, diagnostic and therapeutic approaches tailored to different PH subtypes have evolved, incorporating targeted pharmacological treatments, interventional procedures, and lung transplantation. This review summarizes recent advances in elucidating the mechanisms underlying PH and outlines clinical management strategies across the major etiologic categories. Particular emphasis is placed on developments in PH-specific therapies and on emerging therapeutic targets to provide a coherent mechanistic framework and practical guidance for clinicians involved in the diagnosis and treatment of this challenging disease.
SN  - 1530-6550
SN  - 2153-8174
ER  -