Association of PROMIS Profile-29 based quality of life with heart failure in asymptomatic patients (HERZCHECK)
Abstract
Heart failure is often diagnosed only when symptoms become acute, but early detection could help prevent disease progression. As patient-reported quality of life is strongly associated with heart failure outcomes, it may also serve as an additional correlate with the disease before symptoms occur. This cross-sectional study investigates the associations of quality of life and asymptomatic heart failure and was conducted as an exploratory, hypothesis-generating analysis. It was based on data of 4,509 asymptomatic patients aged 40 to 69 years with at least one cardiovascular risk factor and without known heart failure at the time of quality of life assessment, whose heart failure status was determined during the baseline evaluation. The quality of life of patients with and without asymptomatic heart failure was compared, using logistic regression. Lower Physical Function was associated with higher odds of asymptomatic heart failure in females generally. Among females with hypercholesterolemia, lower physical function and lower pain interference were associated with asymptomatic heart failure, while in females who smoke, lower physical function was associated with asymptomatic heart failure. In males generally, lower Pain Interference and higher Pain Intensity were associated with higher odds of pre-HF, with additional associations of lower Pain Interference in males with diabetes, higher Depression and higher Pain Intensity in males with hypercholesterolemia, and lower Pain Interference and higher Pain Intensity in males who smoke. This study highlights the association between patient-reported physical health domains and asymptomatic heart failure. The findings provide hypothesis-generating insights into the relationship between quality of life and asymptomatic heart failure and highlight the need for longitudinal research.
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BibTeX
@article{nolden2026association,
title = {{Association of PROMIS Profile-29 based quality of life with heart failure in asymptomatic patients (HERZCHECK)}},
author = {Anna Clara Nolden and Gisela Thiede and Rebecca Elisabeth Beyer and Maximilian Leo Müller and Johannes Wieditz and Hannah Kentenich and Diana Graja and Stephanie Sehlen and Henning Steen and Bjoern Andrew Remppis and Alexander Huppertz and Ulf Landmesser and Volkmar Falk and Norbert Frey and Stephanie Stock and Felix Fischer and Tim Friede and Sebastian Kelle},
journal = {Scientific Reports},
year = {2026},
month = oct,
doi = {10.1038/s41598-026-73579-4},
url = {https://www.nature.com/articles/s41598-026-73579-4},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Association of PROMIS Profile-29 based quality of life with heart failure in asymptomatic patients (HERZCHECK)
AU - Anna Clara Nolden
AU - Gisela Thiede
AU - Rebecca Elisabeth Beyer
AU - Maximilian Leo Müller
AU - Johannes Wieditz
AU - Hannah Kentenich
AU - Diana Graja
AU - Stephanie Sehlen
AU - Henning Steen
AU - Bjoern Andrew Remppis
AU - Alexander Huppertz
AU - Ulf Landmesser
AU - Volkmar Falk
AU - Norbert Frey
AU - Stephanie Stock
AU - Felix Fischer
AU - Tim Friede
AU - Sebastian Kelle
PY - 2026
DA - 2026/10/12
JO - Scientific Reports
DO - 10.1038/s41598-026-73579-4
UR - https://www.nature.com/articles/s41598-026-73579-4
AB - Heart failure is often diagnosed only when symptoms become acute, but early detection could help prevent disease progression. As patient-reported quality of life is strongly associated with heart failure outcomes, it may also serve as an additional correlate with the disease before symptoms occur. This cross-sectional study investigates the associations of quality of life and asymptomatic heart failure and was conducted as an exploratory, hypothesis-generating analysis. It was based on data of 4,509 asymptomatic patients aged 40 to 69 years with at least one cardiovascular risk factor and without known heart failure at the time of quality of life assessment, whose heart failure status was determined during the baseline evaluation. The quality of life of patients with and without asymptomatic heart failure was compared, using logistic regression. Lower Physical Function was associated with higher odds of asymptomatic heart failure in females generally. Among females with hypercholesterolemia, lower physical function and lower pain interference were associated with asymptomatic heart failure, while in females who smoke, lower physical function was associated with asymptomatic heart failure. In males generally, lower Pain Interference and higher Pain Intensity were associated with higher odds of pre-HF, with additional associations of lower Pain Interference in males with diabetes, higher Depression and higher Pain Intensity in males with hypercholesterolemia, and lower Pain Interference and higher Pain Intensity in males who smoke. This study highlights the association between patient-reported physical health domains and asymptomatic heart failure. The findings provide hypothesis-generating insights into the relationship between quality of life and asymptomatic heart failure and highlight the need for longitudinal research.
SN - 2045-2322
ER -