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Peer-reviewedCC BYJournal of medical virology

Plasma Interleukin-10 Levels and IL10 Genetic Variants Are Associated With Clinical Outcomes in Patients With Severe COVID-19 Treated With Corticosteroids.

  • Ingrid Fricke-Galindo1
  • Francisco M Ortega-Villafuerte1,2
  • Gloria Pérez-Rubio1
  • Ivette Buendía-Roldán3
  • Julián Ramírez-Bello4
  • Azael A Castillo Morales1,5
  • Leslie Chávez-Galán6
  • Rafael de Jesús Hernández-Zenteno7
  • Espiridión Ramos-Martínez8
  • Salvador García-Carmona1
  • Daniela Josefina Cataneo-Piña9
  • Nora Edith Bautista-Félix10
1 more authors
  • Ramcés Falfán-Valencia1
10 affiliations
  1. 1Pneumogenomics Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
  2. 2Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico.
  3. 3Translational Research Laboratory on Aging and Pulmonary Fibrosis, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
  4. 4Subdirección de Investigación Clínica, Instituto Nacional de Cardiología Ignacio Chávez, México City, Mexico.
  5. 5Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Sinaloa, Culiacán Rosales, Sinaloa, Mexico.
  6. 6Laboratory of Integrative Immunology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
  7. 7Tobacco Smoking and COPD Research Department, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.
  8. 8Unidad de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.
  9. 9Department of Geriatrics and Palliative Care, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.
  10. 10Red Mexicana de Investigación Clínica en Enfermedades Emergentes Infecciosas (LaRed), Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, Mexico City, Mexico.
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Abstract

We aimed to evaluate the association between IL10 variants and plasma IL-10 levels and clinical outcomes in patients with severe COVID-19 treated with corticosteroids. We studied 944 patients with severe COVID-19 who were treated with corticosteroids. The clinical outcomes evaluated were in-hospital mortality and the requirement of invasive mechanical ventilation (IMV). The variants IL10 rs1800872, rs1554286, rs3024505, and rs3122605 were determined using TaqMan SNP assays, and IL-10 levels were measured by ELISA at the start of corticosteroid treatment (T1) and after 8 days (T2). The rs1800872-TT (p = 0.035, OR = 1.55, 95% CI = 1.03-2.33) and the rs1554286-AA genotypes were associated with IMV (padj = 0.036, OR = 2.42, 95% CI = 1.12-5.95). IL-10 levels were higher at T1 than at T2. At T2, IL-10 levels were higher in non-survivors (15.9 vs. 7.0 pg/mL, p < 0.001) and in patients requiring IMV (9.9 vs. 5.5 pg/mL, p < 0.001). Among non-survivors, IL-10 plasma levels did not decrease at T2. The alluvial plot revealed that 51.9% of patients in the highest IL-10 tertile at T1 remained in the highest tertile at T2, with a mortality rate of 50%. IL10 rs1800872 and rs1554286 contribute to the risk of requiring IMV. Elevated IL-10 levels after corticosteroid treatment were linked to in-hospital mortality and IMV.

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Cite

BibTeXRIS
BibTeX
@article{frickegalindo2026plasma,
  title = {{Plasma Interleukin-10 Levels and IL10 Genetic Variants Are Associated With Clinical Outcomes in Patients With Severe COVID-19 Treated With Corticosteroids.}},
  author = {Ingrid Fricke-Galindo and Francisco M Ortega-Villafuerte and Gloria Pérez-Rubio and Ivette Buendía-Roldán and Julián Ramírez-Bello and Azael A Castillo Morales and Leslie Chávez-Galán and Rafael de Jesús Hernández-Zenteno and Espiridión Ramos-Martínez and Salvador García-Carmona and Daniela Josefina Cataneo-Piña and Nora Edith Bautista-Félix and Ramcés Falfán-Valencia},
  journal = {Journal of medical virology},
  year = {2026},
  month = oct,
  doi = {10.1002/jmv.71201},
  url = {https://europepmc.org/article/MED/42960855},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Plasma Interleukin-10 Levels and IL10 Genetic Variants Are Associated With Clinical Outcomes in Patients With Severe COVID-19 Treated With Corticosteroids.
AU  - Ingrid Fricke-Galindo
AU  - Francisco M Ortega-Villafuerte
AU  - Gloria Pérez-Rubio
AU  - Ivette Buendía-Roldán
AU  - Julián Ramírez-Bello
AU  - Azael A Castillo Morales
AU  - Leslie Chávez-Galán
AU  - Rafael de Jesús Hernández-Zenteno
AU  - Espiridión Ramos-Martínez
AU  - Salvador García-Carmona
AU  - Daniela Josefina Cataneo-Piña
AU  - Nora Edith Bautista-Félix
AU  - Ramcés Falfán-Valencia
PY  - 2026
DA  - 2026/10/30
JO  - Journal of medical virology
DO  - 10.1002/jmv.71201
UR  - https://europepmc.org/article/MED/42960855
AB  - We aimed to evaluate the association between IL10 variants and plasma IL-10 levels and clinical outcomes in patients with severe COVID-19 treated with corticosteroids. We studied 944 patients with severe COVID-19 who were treated with corticosteroids. The clinical outcomes evaluated were in-hospital mortality and the requirement of invasive mechanical ventilation (IMV). The variants IL10 rs1800872, rs1554286, rs3024505, and rs3122605 were determined using TaqMan SNP assays, and IL-10 levels were measured by ELISA at the start of corticosteroid treatment (T1) and after 8 days (T2). The rs1800872-TT (p = 0.035, OR = 1.55, 95% CI = 1.03-2.33) and the rs1554286-AA genotypes were associated with IMV (padj = 0.036, OR = 2.42, 95% CI = 1.12-5.95). IL-10 levels were higher at T1 than at T2. At T2, IL-10 levels were higher in non-survivors (15.9 vs. 7.0 pg/mL, p < 0.001) and in patients requiring IMV (9.9 vs. 5.5 pg/mL, p < 0.001). Among non-survivors, IL-10 plasma levels did not decrease at T2. The alluvial plot revealed that 51.9% of patients in the highest IL-10 tertile at T1 remained in the highest tertile at T2, with a mortality rate of 50%. IL10 rs1800872 and rs1554286 contribute to the risk of requiring IMV. Elevated IL-10 levels after corticosteroid treatment were linked to in-hospital mortality and IMV.
SN  - 0146-6615
SN  - 1096-9071
ER  -