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PreprintLicence not statedChemRxiv

DEL-Flow: AI-Driven Structural Generation and Activity Validation of MDM2-Targeting Macrocyclic Peptides

  • Hanqi Du1,2
  • Zijian Liu1,2
  • Yunzhe Wang1,3
  • Shijie Zhang1,2
  • Jiajun Yu1,4,5
  • Qingyi Zhao6
  • Weiwei Lu1
  • Yujun Zhao7,8,9,10
  • Xuan Wang6
  • Xiaojie Lu1,2
10 affiliations
  1. 1Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhang Jiang Hi-Tech Park, Pudong, Shanghai, China, 201203
  2. 2University of Chinese Academy of Sciences, No. 19AYuquan Road, Beijing, China, 100049
  3. 3College of Pharmacy, Nanjing University of Chinese Medicine, No.138 Xianlin Avenue, Qixia District, Nanjing, Jiangsu, China, 210023
  4. 4School of Pharmaceutical Engineering
  5. 5Shenyang Pharmaceutical University
  6. 6Alphama Biotechnology Suzhou Co., Ltd.
  7. 7State Key Laboratory of Green Chemical Synthesis and Conversion, College of Pharmaceutical Sciences and Institute of Pharmaceutical Science and Technology
  8. 8Zhejiang University of Technology
  9. 9Key Laboratory for Green Pharmaceutical Technology and Equipment
  10. 10Zhejiang University of Technology) of Ministry of Education, and Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs
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Cite

BibTeXRIS
BibTeX
@misc{du2026delflow,
  title = {{DEL-Flow: AI-Driven Structural Generation and Activity Validation of MDM2-Targeting Macrocyclic Peptides}},
  author = {Hanqi Du and Zijian Liu and Yunzhe Wang and Shijie Zhang and Jiajun Yu and Qingyi Zhao and Weiwei Lu and Yujun Zhao and Xuan Wang and Xiaojie Lu},
  howpublished = {ChemRxiv},
  year = {2026},
  month = nov,
  doi = {10.26434/chemrxiv.15011669/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15011669/v1},
}
RIS
TY  - UNPB
TI  - DEL-Flow: AI-Driven Structural Generation and Activity Validation of MDM2-Targeting Macrocyclic Peptides
AU  - Hanqi Du
AU  - Zijian Liu
AU  - Yunzhe Wang
AU  - Shijie Zhang
AU  - Jiajun Yu
AU  - Qingyi Zhao
AU  - Weiwei Lu
AU  - Yujun Zhao
AU  - Xuan Wang
AU  - Xiaojie Lu
PY  - 2026
DA  - 2026/11/04
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15011669/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15011669/v1
ER  -