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Peer-reviewedCC BY 4.0Scientific Reports

Localized transplantation of periodontal ligament-derived mesenchymal stromal cell sheets promotes mandibular wound healing in zoledronate-treated beagle dogs

  • Nobuyuki Kaibuchi
  • Takanori Iwata
  • Masayuki Yamato
  • Kazuhiro Nishimaki
  • Shinichi Kitsukawa
  • Ryo Takagi
  • Hajime Matsumine
  • Monika Nakano
  • Yoko Kawase-Koga
  • Toshihiro Okamoto
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Abstract

Medication-related osteonecrosis of the jaw (MRONJ) is associated with impaired wound healing, and approaches that support tissue repair warrant investigation. We evaluated the effects of localized periodontal ligament-derived mesenchymal stromal cell (PDL-MSC) sheet transplantation on mandibular wound healing in zoledronate-treated beagle dogs. Following zoledronate administration, mandibular bone injuries were surgically created. Allogeneic canine PDL-MSC sheets combined with polyglycolic acid (PGA) sheets were applied to wounds on one side of the mandible, while contralateral wounds received PGA sheets alone. Mucosal healing and histological findings were assessed two weeks later. The PDL-MSC sheet-treated sites showed better mucosal healing and smaller histological areas of inflammatory mucosa and sequestrated bone than the PGA-only control sites. These findings suggest that localized PDL-MSC sheet transplantation may improve short-term healing of surgically created mandibular wounds under zoledronate exposure. This study did not evaluate treatment of established MRONJ. Further studies are needed to determine whether the observed effects extend to persistent jaw lesions and are relevant to MRONJ.

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Cite

BibTeXRIS
BibTeX
@article{kaibuchi2026localized,
  title = {{Localized transplantation of periodontal ligament-derived mesenchymal stromal cell sheets promotes mandibular wound healing in zoledronate-treated beagle dogs}},
  author = {Nobuyuki Kaibuchi and Takanori Iwata and Masayuki Yamato and Kazuhiro Nishimaki and Shinichi Kitsukawa and Ryo Takagi and Hajime Matsumine and Monika Nakano and Yoko Kawase-Koga and Toshihiro Okamoto},
  journal = {Scientific Reports},
  year = {2026},
  month = oct,
  doi = {10.1038/s41598-026-75308-3},
  url = {https://www.nature.com/articles/s41598-026-75308-3},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Localized transplantation of periodontal ligament-derived mesenchymal stromal cell sheets promotes mandibular wound healing in zoledronate-treated beagle dogs
AU  - Nobuyuki Kaibuchi
AU  - Takanori Iwata
AU  - Masayuki Yamato
AU  - Kazuhiro Nishimaki
AU  - Shinichi Kitsukawa
AU  - Ryo Takagi
AU  - Hajime Matsumine
AU  - Monika Nakano
AU  - Yoko Kawase-Koga
AU  - Toshihiro Okamoto
PY  - 2026
DA  - 2026/10/09
JO  - Scientific Reports
DO  - 10.1038/s41598-026-75308-3
UR  - https://www.nature.com/articles/s41598-026-75308-3
AB  - Medication-related osteonecrosis of the jaw (MRONJ) is associated with impaired wound healing, and approaches that support tissue repair warrant investigation. We evaluated the effects of localized periodontal ligament-derived mesenchymal stromal cell (PDL-MSC) sheet transplantation on mandibular wound healing in zoledronate-treated beagle dogs. Following zoledronate administration, mandibular bone injuries were surgically created. Allogeneic canine PDL-MSC sheets combined with polyglycolic acid (PGA) sheets were applied to wounds on one side of the mandible, while contralateral wounds received PGA sheets alone. Mucosal healing and histological findings were assessed two weeks later. The PDL-MSC sheet-treated sites showed better mucosal healing and smaller histological areas of inflammatory mucosa and sequestrated bone than the PGA-only control sites. These findings suggest that localized PDL-MSC sheet transplantation may improve short-term healing of surgically created mandibular wounds under zoledronate exposure. This study did not evaluate treatment of established MRONJ. Further studies are needed to determine whether the observed effects extend to persistent jaw lesions and are relevant to MRONJ.
SN  - 2045-2322
ER  -