PTM-PAL Pipeline: A Python Web Platform of Integrative Scoring System for Assessing the Functional Impact of Protein S-Palmitoylation.
- 1Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, Shanghai 200032, China.
- 2Department of Good Clinical Practice, Medical Guarantee Center, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China.
- 3Independent Researcher, Shanghai 201210, China.
Abstract
S-palmitoylation is a reversible lipid modification that can alter protein localization, stability, interactions and signaling, but detection of a modified cysteine does not establish its functional importance. Post-translational Modification-Palmoylation Pipeline(PTM-PAL) is a web-accessible workflow for prioritizing candidate S-palmitoylation sites and modification configurations for functional follow-up. It integrates site-specific evolutionary context and UniProt annotation, paired wild-type and palmitoylated structural models, local protein-body solvent-accessible surface-area remodeling, and membrane-embedding descriptors. The workflow takes site metadata, full-length sequences and paired WT/PAL structural models as input and returns dimension-resolved outputs together with a within-protein score on a 0-10 scale. Single-site and dual-site configurations can be examined separately, while the underlying measurements remain available for inspection. PTM-PAL is intended to organize heterogeneous biochemical, structural and membrane-related evidence into testable priorities; the score is not a calibrated probability and does not replace biochemical or functional validation.
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BibTeX
@article{bi2026ptmpal,
title = {{PTM-PAL Pipeline: A Python Web Platform of Integrative Scoring System for Assessing the Functional Impact of Protein S-Palmitoylation.}},
author = {Xin-Yu Bi and Jia-Ni Chen and Xiong-Fei Pan and Ling Tao},
journal = {Membranes},
year = {2026},
month = oct,
doi = {10.3390/membranes16100341},
url = {https://europepmc.org/article/MED/42931019},
note = {CC BY},
}
RIS
TY - JOUR
TI - PTM-PAL Pipeline: A Python Web Platform of Integrative Scoring System for Assessing the Functional Impact of Protein S-Palmitoylation.
AU - Xin-Yu Bi
AU - Jia-Ni Chen
AU - Xiong-Fei Pan
AU - Ling Tao
PY - 2026
DA - 2026/10/14
JO - Membranes
DO - 10.3390/membranes16100341
UR - https://europepmc.org/article/MED/42931019
AB - S-palmitoylation is a reversible lipid modification that can alter protein localization, stability, interactions and signaling, but detection of a modified cysteine does not establish its functional importance. Post-translational Modification-Palmoylation Pipeline(PTM-PAL) is a web-accessible workflow for prioritizing candidate S-palmitoylation sites and modification configurations for functional follow-up. It integrates site-specific evolutionary context and UniProt annotation, paired wild-type and palmitoylated structural models, local protein-body solvent-accessible surface-area remodeling, and membrane-embedding descriptors. The workflow takes site metadata, full-length sequences and paired WT/PAL structural models as input and returns dimension-resolved outputs together with a within-protein score on a 0-10 scale. Single-site and dual-site configurations can be examined separately, while the underlying measurements remain available for inspection. PTM-PAL is intended to organize heterogeneous biochemical, structural and membrane-related evidence into testable priorities; the score is not a calibrated probability and does not replace biochemical or functional validation.
SN - 2077-0375
ER -