Effects of dexmedetomidine nasal spray on postoperative sleep-related indicators in patients undergoing laparoscopic cholecystectomy
- 1Department of Anesthesiology,Perioperative and Pain Medicine,Nanjing First Hospital,Nanjing Medical University,Nanjing,Jiangsu 210006,China
Abstract
Objective To explore the effects of dexmedetomidine nasal spray on postoperative sleep-related indicators,serum inflammatory factors,and neurotransmitter levels in patients undergoing laparoscopic cholecystectomy.Methods Sixty patients undergoing the first scheduled laparoscopic cholecystectomy of the day were selected from Nanjing First Hospital between October 2023 and October 2025. Using a random number table method,the subjects were divided into a control group and a dexmedetomidine group,and then based on the midnight salivary melatonin levels at admission,they were further divided into a normal level subgroup(10-40 pg/mL)and a low level subgroup(<10 pg/mL),and both groups had 16 cases in the normal level subgroup and 14 cases in the low level subgroup. The control group received routine clinical nursing and diagnosis-treatment protocols. For the dexmedetomidine group ,from the day after admission to the day before discharge,at 10:00 p.m. each night and 30 seconds later,dexmedetomidine nasal spray was administered to each nostril twice,one spray each time(total of 100 μg for the two doses each side). Both groups received standardized anesthesia protocols and management. Midnight salivary melatonin levels,fasting serum levels of inflammatory factors［interleukin(IL)-8,tumor necrosis factor-α(TNF-α),IL-6］,cortisol(Cor)and neurotransmitters［norepinephrine(NE),dopamine(DA),5 - hydroxytryptamine (5 - HT)and acetylcholine(Ach)］were recorded at admission and discharge. Results At discharge,compared with the normal level subgroup of the control group,the midnight melatonin level in the normal level subgroup of dexmedetomidine group was higher ［(22.95±4.75)pg/mL vs(11.35±5.05)pg/mL,t=6.689,P<0.01］,while there was no significant difference between the patients in the low level subgroups of dexmedetomidine group and control group［(6.35±3.15)pg/mL vs(9.25±4.45)pg/mL,t=1.991,P=0.057］. At admission,there were no statistically significant differences between the two groups in serum levels of IL-8,TNF-α,IL-6,Cor,NE,DA,5-HT,and Ach(P>0.05). At discharge,compared with the control group,the levels of IL-8,TNF-α,IL-6,Cor,NE and DA in dexmedetomidine group were lower,and the levels of 5-HT and Achwerehigher(P<0.05).Conclusion Dexmedetomidine nasal spray can increase midnight salivary melatonin levels at discharge in patients with normal baseline melatonin levels,whereas no significant effect is observed in patients with low baseline levels. It may also attenuate perioperative alterations in inflammatory and neuroendocrine markers.
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BibTeX
@article{xiaodan2026effects,
title = {{Effects of dexmedetomidine nasal spray on postoperative sleep-related indicators in patients undergoing laparoscopic cholecystectomy}},
author = {ZHANG Xiaodan and ZHOU Xiao and WEI Jie and JIANG Yuzhi},
journal = {Zhongguo linchuang yanjiu},
year = {2026},
month = oct,
doi = {10.13429/j.cnki.cjcr.2026.10.024},
url = {https://doi.org/10.13429/j.cnki.cjcr.2026.10.024},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Effects of dexmedetomidine nasal spray on postoperative sleep-related indicators in patients undergoing laparoscopic cholecystectomy
AU - ZHANG Xiaodan
AU - ZHOU Xiao
AU - WEI Jie
AU - JIANG Yuzhi
PY - 2026
DA - 2026/10/26
JO - Zhongguo linchuang yanjiu
DO - 10.13429/j.cnki.cjcr.2026.10.024
UR - https://doi.org/10.13429/j.cnki.cjcr.2026.10.024
AB - Objective To explore the effects of dexmedetomidine nasal spray on postoperative sleep-related indicators,serum inflammatory factors,and neurotransmitter levels in patients undergoing laparoscopic cholecystectomy.Methods Sixty patients undergoing the first scheduled laparoscopic cholecystectomy of the day were selected from Nanjing First Hospital between October 2023 and October 2025. Using a random number table method,the subjects were divided into a control group and a dexmedetomidine group,and then based on the midnight salivary melatonin levels at admission,they were further divided into a normal level subgroup(10-40 pg/mL)and a low level subgroup(<10 pg/mL),and both groups had 16 cases in the normal level subgroup and 14 cases in the low level subgroup. The control group received routine clinical nursing and diagnosis-treatment protocols. For the dexmedetomidine group ,from the day after admission to the day before discharge,at 10:00 p.m. each night and 30 seconds later,dexmedetomidine nasal spray was administered to each nostril twice,one spray each time(total of 100 μg for the two doses each side). Both groups received standardized anesthesia protocols and management. Midnight salivary melatonin levels,fasting serum levels of inflammatory factors［interleukin(IL)-8,tumor necrosis factor-α(TNF-α),IL-6］,cortisol(Cor)and neurotransmitters［norepinephrine(NE),dopamine(DA),5 - hydroxytryptamine (5 - HT)and acetylcholine(Ach)］were recorded at admission and discharge. Results At discharge,compared with the normal level subgroup of the control group,the midnight melatonin level in the normal level subgroup of dexmedetomidine group was higher ［(22.95±4.75)pg/mL vs(11.35±5.05)pg/mL,t=6.689,P<0.01］,while there was no significant difference between the patients in the low level subgroups of dexmedetomidine group and control group［(6.35±3.15)pg/mL vs(9.25±4.45)pg/mL,t=1.991,P=0.057］. At admission,there were no statistically significant differences between the two groups in serum levels of IL-8,TNF-α,IL-6,Cor,NE,DA,5-HT,and Ach(P>0.05). At discharge,compared with the control group,the levels of IL-8,TNF-α,IL-6,Cor,NE and DA in dexmedetomidine group were lower,and the levels of 5-HT and Achwerehigher(P<0.05).Conclusion Dexmedetomidine nasal spray can increase midnight salivary melatonin levels at discharge in patients with normal baseline melatonin levels,whereas no significant effect is observed in patients with low baseline levels. It may also attenuate perioperative alterations in inflammatory and neuroendocrine markers.
SN - 1674-8182
ER -