Correlation between carotid artery elasticity assessed by ultrafast pulse wave velocity and atherogenic index of plasma in adults
Abstract
Objective To investigate the correlation between carotid artery elasticity quantitatively assessed by ultrafast pulse wave velocity (ufPWV) and the atherogenic index of plasma (AIP) in adults.Methods A total of 596 participants were enrolled, and their clinical data were collected. Carotid intima-media thickness (cIMT), pulse wave velocity at the beginning of systole (PWV-BS), and pulse wave velocity at the end of systole (PWV-ES) of the common carotid artery were measured using ufPWV. According to the median AIP value (-0.030 5), the participants were divided into an AIP-Low group (AIP<-0.030 5, n=298) and an AIP-High group (AIP>-0.030 5, n=298). Clinical characteristics and ultrasonographic parameters were compared between the two groups, and correlation analyses were performed. Logistic regression analysis was used to evaluate the association between ufPWV and AIP and to identify influencing factors.Results Significant differences were observed between the two groups in sex, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), prevalence of hypertension, serum creatinine, blood urea nitrogen, uric acid, blood glucose, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), cIMT, and PWV-ES (all P<0.05), whereas no significant differences were found in age, hemoglobin (Hb), total cholesterol (TC), or PWV-BS (all P>0.05). cIMT, PWV-BS, and PWV-ES were positively correlated with sex, age, BMI, SBP, hypertension, uric acid, and blood glucose (all P<0.05). Both cIMT and PWV-ES were positively correlated with AIP, with PWV-ES showing the strongest correlation with AIP (r=0.159,P<0.05). No significant correlation was observed between PWV-BS and AIP (r=0.046,P>0.05). Logistic regression analysis showed that PWV-ES was independently associated with high AIP (OR=1.141, P<0.001), after adjustment for age, sex, BMI, blood glucose, and other potential confounding factors.Conclusions PWV-ES is significantly correlated with AIP. Routine assessment of PWV-ES using ufPWV in individuals with high AIP may facilitate the early identification of carotid arterial stiffness and provide valuable information for the early assessment of atherosclerosis.
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BibTeX
@article{xuguang2026correlation,
title = {{Correlation between carotid artery elasticity assessed by ultrafast pulse wave velocity and atherogenic index of plasma in adults}},
author = {SONG Xuguang and ZHU Zhengqiu and WU Linlin and HUANG Hui and LIU Niu},
journal = {徐州医科大学学报},
year = {2026},
month = sep,
doi = {10.12467/j.issn.2096-3882.20250977},
url = {https://doi.org/10.12467/j.issn.2096-3882.20250977},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Correlation between carotid artery elasticity assessed by ultrafast pulse wave velocity and atherogenic index of plasma in adults
AU - SONG Xuguang
AU - ZHU Zhengqiu
AU - WU Linlin
AU - HUANG Hui
AU - LIU Niu
PY - 2026
DA - 2026/09/01
JO - 徐州医科大学学报
DO - 10.12467/j.issn.2096-3882.20250977
UR - https://doi.org/10.12467/j.issn.2096-3882.20250977
AB - Objective To investigate the correlation between carotid artery elasticity quantitatively assessed by ultrafast pulse wave velocity (ufPWV) and the atherogenic index of plasma (AIP) in adults.Methods A total of 596 participants were enrolled, and their clinical data were collected. Carotid intima-media thickness (cIMT), pulse wave velocity at the beginning of systole (PWV-BS), and pulse wave velocity at the end of systole (PWV-ES) of the common carotid artery were measured using ufPWV. According to the median AIP value (-0.030 5), the participants were divided into an AIP-Low group (AIP<-0.030 5, n=298) and an AIP-High group (AIP>-0.030 5, n=298). Clinical characteristics and ultrasonographic parameters were compared between the two groups, and correlation analyses were performed. Logistic regression analysis was used to evaluate the association between ufPWV and AIP and to identify influencing factors.Results Significant differences were observed between the two groups in sex, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), prevalence of hypertension, serum creatinine, blood urea nitrogen, uric acid, blood glucose, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), cIMT, and PWV-ES (all P<0.05), whereas no significant differences were found in age, hemoglobin (Hb), total cholesterol (TC), or PWV-BS (all P>0.05). cIMT, PWV-BS, and PWV-ES were positively correlated with sex, age, BMI, SBP, hypertension, uric acid, and blood glucose (all P<0.05). Both cIMT and PWV-ES were positively correlated with AIP, with PWV-ES showing the strongest correlation with AIP (r=0.159,P<0.05). No significant correlation was observed between PWV-BS and AIP (r=0.046,P>0.05). Logistic regression analysis showed that PWV-ES was independently associated with high AIP (OR=1.141, P<0.001), after adjustment for age, sex, BMI, blood glucose, and other potential confounding factors.Conclusions PWV-ES is significantly correlated with AIP. Routine assessment of PWV-ES using ufPWV in individuals with high AIP may facilitate the early identification of carotid arterial stiffness and provide valuable information for the early assessment of atherosclerosis.
SN - 2096-3882
ER -